دورية أكاديمية
أعرض في EDS

Effect of a Physical Exercise Program on the Inflammatory Response, Cardiac Functions, Functional Capacity, and Quality of Life in Patients with Sickle Cell Disease.

التفاصيل البيبلوغرافية
العنوان: Effect of a Physical Exercise Program on the Inflammatory Response, Cardiac Functions, Functional Capacity, and Quality of Life in Patients with Sickle Cell Disease.
المؤلفون: Antonelli Rossi DA; Department of Internal Medicine, Botucatu Medical School-UNESP, São Paulo State University, Botucatu 18618-687, Brazil., De Araujo Junior JA; Department of Internal Medicine, Botucatu Medical School-UNESP, São Paulo State University, Botucatu 18618-687, Brazil., Luvizutto GJ; Department of Applied Physical Therapy, Federal University of Triângulo Mineiro, Uberaba 38065-430, Brazil., Bazan R; Department of Neurology, Botucatu Medical School-UNESP, São Paulo State University, Botucatu 18618-970, Brazil., Salmazo PS; Department of Medicine, Faculty of Medical and Health Sciences, Pontifical Catholic University of São Paulo, Sorocaba 18052-490, Brazil., Modolo GP; Department of Neurology, Botucatu Medical School-UNESP, São Paulo State University, Botucatu 18618-970, Brazil., Hueb JC; Department of Internal Medicine, Botucatu Medical School-UNESP, São Paulo State University, Botucatu 18618-687, Brazil., Nunes HRC; Department of Biostatistics, Botucatu Medical School-UNESP, São Paulo State University, Botucatu 18618-689, Brazil., Hokama NK; Department of Internal Medicine, Botucatu Medical School-UNESP, São Paulo State University, Botucatu 18618-687, Brazil., Minicucci MF; Department of Internal Medicine, Botucatu Medical School-UNESP, São Paulo State University, Botucatu 18618-687, Brazil., Roscani MG; Department of Medicine, Federal University of Sao Carlos-UFSCar, São Carlos 13565-251, Brazil., Zanati Bazan SG; Department of Internal Medicine, Botucatu Medical School-UNESP, São Paulo State University, Botucatu 18618-687, Brazil.
المصدر: Journal of clinical medicine [J Clin Med] 2023 Jun 09; Vol. 12 (12). Date of Electronic Publication: 2023 Jun 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101606588 Publication Model: Electronic Cited Medium: Print ISSN: 2077-0383 (Print) Linking ISSN: 20770383 NLM ISO Abbreviation: J Clin Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2012]-
مستخلص: Introduction: The beneficial effects of physical exercise on functional capacity and inflammatory response are well-known in cardiovascular diseases; however, studies on sickle cell disease (SCD) are limited. It was hypothesized that physical exercise may exert a favorable effect on the inflammatory response of SCD patients, contributing to an improved quality of life. This study aimed to evaluate the effect of a regular physical exercise program on the anti-inflammatory responses in SCD patients.
Methods: A non-randomized clinical trial was conducted in adult SCD patients. The patients were divided into two groups: 1-Exercise Group, which received a physical exercise program three times a week for 8 weeks, and; 2-Control Group, with routine physical activities. All patients underwent the following procedures initially and after eight weeks of protocol: clinical evaluation, physical evaluation, laboratory evaluation, quality of life evaluation, and echocardiographic evaluation.
Statistical Analysis: Comparisons between groups were made using Student's t -test, Mann-Whitney test, chi-square test, or Fisher's exact test. Spearman's correlation coefficient was calculated. The significance level was set at p < 0.05.
Results: There was no significant difference in inflammatory response between the Control and Exercise Groups. The Exercise Group showed an improvement in peak VO 2 values ( p < 0.001), an increase in the distance walked ( p < 0.001), an improvement in the limitation domain due to the physical aspects of the 36-Item Short Form Health Survey (SF-36) quality of life questionnaire ( p = 0.022), and an increase in physical activity related to leisure ( p < 0.001) and walking ( p = 0.024) in the International Physical Activity Questionnaire (IPAQ). There was a negative correlation between IL-6 values and distance walked on the treadmill (correlation coefficient -0.444, p = 0.020) and the estimated peak VO 2 values (correlation coefficient -0.480; p = 0.013) in SCD patients in both groups.
Conclusions: The aerobic exercise program did not change the inflammatory response profile of SCD patients, nor did it show unfavorable effects on the parameters evaluated, and patients with lower functional capacity were those with the highest levels of IL-6.
References: J Interferon Cytokine Res. 1995 Dec;15(12):1061-4. (PMID: 8746787)
J Clin Med. 2019 Dec 05;8(12):. (PMID: 31817545)
N Engl J Med. 1994 Jun 9;330(23):1639-44. (PMID: 7993409)
N Engl J Med. 1997 Sep 11;337(11):762-9. (PMID: 9287233)
Hematol Oncol Clin North Am. 2005 Oct;19(5):881-96, vii. (PMID: 16214649)
J Appl Physiol (1985). 2010 Mar;108(3):621-7. (PMID: 20056848)
Med Care. 1992 Jun;30(6):473-83. (PMID: 1593914)
Annu Rev Physiol. 1983;45:169-89. (PMID: 6221687)
J Am Soc Echocardiogr. 2015 Jan;28(1):1-39.e14. (PMID: 25559473)
Mediators Inflamm. 2008;2008:109502. (PMID: 19148295)
Blood. 2019 Dec 19;134(25):2233-2241. (PMID: 31742587)
Eur Cytokine Netw. 2013 Mar;24(1):45-52. (PMID: 23608554)
Sports Med. 2016 May;46(5):629-39. (PMID: 26666745)
J Leukoc Biol. 2009 Feb;85(2):235-42. (PMID: 19004988)
Endothelium. 2001;8(2):147-55. (PMID: 11572476)
Med Sci Sports Exerc. 1994 Jan;26(1):103-7. (PMID: 8133729)
Afr Health Sci. 2018 Mar;18(1):111-119. (PMID: 29977264)
Clin Hemorheol Microcirc. 2011;49(1-4):151-63. (PMID: 22214686)
Br J Haematol. 2011 Aug;154(4):512-20. (PMID: 21689089)
Immunohematology. 2009;25(2):67-74. (PMID: 19927623)
Eur J Clin Invest. 2017 Aug;47(8):600-611. (PMID: 28722106)
Biochim Biophys Acta Mol Basis Dis. 2020 Oct 1;1866(10):165823. (PMID: 32360589)
Arq Bras Cardiol. 2019 Nov 04;113(4):787-891. (PMID: 31691761)
Rev Port Cardiol. 1994 Oct;13(10):753-60; 735-6. (PMID: 7833062)
Rev Bras Hematol Hemoter. 2015 Sep-Oct;37(5):329-35. (PMID: 26408368)
J Am Coll Cardiol. 2001 Feb;37(2):392-7. (PMID: 11216952)
Lancet. 2017 Jul 15;390(10091):311-323. (PMID: 28159390)
Am J Epidemiol. 2000 May 1;151(9):839-45. (PMID: 10791557)
Postgrad Med J. 2003 Jul;79(933):384-90. (PMID: 12897216)
Med Sci Sports Exerc. 2011 Jul;43(7):1334-59. (PMID: 21694556)
Exp Physiol. 2018 Sep;103(9):1213-1220. (PMID: 30024072)
Front Immunol. 2020 Mar 13;11:454. (PMID: 32231672)
Rev Paul Pediatr. 2018 Oct-Dec;36(4):491-499. (PMID: 30540112)
Annu Rev Pathol. 2019 Jan 24;14:263-292. (PMID: 30332562)
J Am Coll Cardiol. 2012 Mar 27;59(13):1123-33. (PMID: 22440212)
Cytokine. 2015 Mar;72(1):43-7. (PMID: 25569375)
J Appl Physiol (1985). 2005 Apr;98(4):1154-62. (PMID: 15772055)
Br J Sports Med. 2018 Feb;52(4):214-218. (PMID: 26701924)
Hematology Am Soc Hematol Educ Program. 2017 Dec 8;2017(1):423-430. (PMID: 29222288)
QJM. 2017 Oct 01;110(10):629-637. (PMID: 28472518)
Lancet. 2010 Dec 11;376(9757):2018-31. (PMID: 21131035)
Prog Cardiovasc Dis. 2019 Mar - Apr;62(2):163-171. (PMID: 30227187)
Ann Hematol. 2000 Aug;79(8):407-13. (PMID: 10985359)
Clin Appl Thromb Hemost. 2012 Mar-Apr;18(2):195-200. (PMID: 21949038)
Nat Rev Immunol. 2011 Aug 05;11(9):607-15. (PMID: 21818123)
Br J Haematol. 2013 Jul;162(1):3-14. (PMID: 23593937)
Int J Obes. 1985;9(2):147-53. (PMID: 4030199)
Am J Cardiol. 1992 Jan 1;69(1):84-9. (PMID: 1729872)
فهرسة مساهمة: Keywords: functional capacity; hemoglobinopathies; inflammation; physical activity
تواريخ الأحداث: Date Created: 20230628 Latest Revision: 20230701
رمز التحديث: 20230701
مُعرف محوري في PubMed: PMC10299033
DOI: 10.3390/jcm12123952
PMID: 37373647
قاعدة البيانات: MEDLINE
الوصف
تدمد:2077-0383
DOI:10.3390/jcm12123952