دورية أكاديمية
360-Degree Perspectives on Obesity.
| العنوان: | 360-Degree Perspectives on Obesity. |
|---|---|
| المؤلفون: | Cuciureanu M; Department of Pharmacology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Caratașu CC; Department of Pharmacology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Center for Advanced Research and Development in Experimental Medicine (CEMEX), 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Gabrielian L; Department of Anatomy and Pathology, The University of Adelaide, Adelaide 5000, Australia., Frăsinariu OE; Department of Mother and Child, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Checheriță LE; 2nd Dental Medicine Department, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Trandafir LM; Department of Mother and Child, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Stanciu GD; Center for Advanced Research and Development in Experimental Medicine (CEMEX), 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Szilagyi A; Center for Advanced Research and Development in Experimental Medicine (CEMEX), 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Pogonea I; Department of Pharmacology and Clinical Pharmacology, 'Nicolae Testemiţanu' State University of Medicine and Pharmacy, 2004 Chisinau, Moldova., Bordeianu G; Department of Biochemistry, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Soroceanu RP; Department of Surgery, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Andrițoiu CV; Specialization of Nutrition and Dietetics, 'Vasile Goldis' Western University of Arad, 310025 Arad, Romania., Anghel MM; Department of Pharmacology and Clinical Pharmacology, 'Nicolae Testemiţanu' State University of Medicine and Pharmacy, 2004 Chisinau, Moldova., Munteanu D; Institute of Mother and Child, 'Nicolae Testemiţanu' State University of Medicine and Pharmacy, 2062 Chisinau, Moldova., Cernescu IT; Department of Pharmacology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania., Tamba BI; Department of Pharmacology, 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania.; Center for Advanced Research and Development in Experimental Medicine (CEMEX), 'Grigore T. Popa' University of Medicine and Pharmacy, 700115 Iasi, Romania. |
| المصدر: | Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2023 Jun 09; Vol. 59 (6). Date of Electronic Publication: 2023 Jun 09. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2018- : Basel, Switzerland : MDPI Original Publication: Kaunas : Lietuvos gydytojų sąjunga |
| مواضيع طبية MeSH: | Obesity*/complications , Obesity*/therapy , Obesity*/epidemiology , Bariatric Surgery*, Animals |
| مستخلص: | Alarming statistics show that the number of people affected by excessive weight has surpassed 2 billion, representing approximately 30% of the world's population. The aim of this review is to provide a comprehensive overview of one of the most serious public health problems, considering that obesity requires an integrative approach that takes into account its complex etiology, including genetic, environmental, and lifestyle factors. Only an understanding of the connections between the many contributors to obesity and the synergy between treatment interventions can ensure satisfactory outcomes in reducing obesity. Mechanisms such as oxidative stress, chronic inflammation, and dysbiosis play a crucial role in the pathogenesis of obesity and its associated complications. Compounding factors such as the deleterious effects of stress, the novel challenge posed by the obesogenic digital (food) environment, and the stigma associated with obesity should not be overlooked. Preclinical research in animal models has been instrumental in elucidating these mechanisms, and translation into clinical practice has provided promising therapeutic options, including epigenetic approaches, pharmacotherapy, and bariatric surgery. However, more studies are necessary to discover new compounds that target key metabolic pathways, innovative ways to deliver the drugs, the optimal combinations of lifestyle interventions with allopathic treatments, and, last but not least, emerging biological markers for effective monitoring. With each passing day, the obesity crisis tightens its grip, threatening not only individual lives but also burdening healthcare systems and societies at large. It is high time we took action as we confront the urgent imperative to address this escalating global health challenge head-on. |
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| معلومات مُعتمدة: | project code: 1HARD/4.1/93 EU |
| فهرسة مساهمة: | Keywords: PTSD; bariatric surgery; epigenetics; genetics; microbiota; obesity; pharmacotherapy; stress |
| تواريخ الأحداث: | Date Created: 20230628 Date Completed: 20230629 Latest Revision: 20230701 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10304508 |
| DOI: | 10.3390/medicina59061119 |
| PMID: | 37374323 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1648-9144 |
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| DOI: | 10.3390/medicina59061119 |