التفاصيل البيبلوغرافية
| العنوان: |
Initial Postoperative Prostate Specific Antigen and PSA Velocity Are Important Indicators of Underlying Malignancy After Simple Prostatectomy. |
| المؤلفون: |
Livingston AJ; Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA., Dvergsten T; Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA., Morgan TN; Division of Urology, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA. |
| المصدر: |
Journal of endourology [J Endourol] 2023 Sep; Vol. 37 (9), pp. 1057-1062. Date of Electronic Publication: 2023 Jul 31. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8807503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-900X (Electronic) Linking ISSN: 08927790 NLM ISO Abbreviation: J Endourol Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: New York : Mary Ann Liebert, [c1987- |
| مواضيع طبية MeSH: |
Prostate-Specific Antigen* , Prostatic Neoplasms*/surgery, Male ; Humans ; Quality of Life ; Prostatectomy ; Prostate/pathology |
| مستخلص: |
Background: There is a paucity of guidelines for prostate-specific antigen (PSA) monitoring after simple prostatectomy (SP) despite these patients remaining at risk for prostate cancer (PCa). Our objective was to determine if PSA kinetics can be a potential indicator of PCa after SP. Methods: A retrospective review was performed of all simple prostatectomies at our institution from 2014 to 2022. All patients who met criteria were included in the study. Relevant clinical variables were collected preoperatively, including PSA value, prostate size, and voiding symptoms. Surgical and urinary function outcomes were analyzed. Results: A total of 92 patients were divided into two groups based on malignancy status. Sixty-eight patients did not have PCa, while 24 patients had known PCa before surgery (14) or were diagnosed as having incidental PCa from the pathological specimen (10). Patients with benign prostates had an initial postoperative PSA value of 0.76 ng/mL compared with 1.68 ng/mL for those with cancer ( p < 0.01). PSA velocity for the first 24 months after surgery was 0.042 ± 1.61 ng/(mL·year) for the benign cohort compared with 1.29 ± 1.02 ng/(mL·year) for the malignant cohort ( p = 0.01). Voiding improvements were noted by objective (postvoid residual and flow rate) and subjective (American Urological Association symptom score and quality of life score) measures in both groups. Conclusions: PSA interpretation and monitoring after SP have not been well established. Our study indicates that initial postoperative PSA value and PSA velocity are important indicators of underlying malignancy in patients after SP. Further efforts are needed to establish threshold values and formal guidelines. |
| فهرسة مساهمة: |
Keywords: lower urinary tract symptoms; prostate cancer; prostate specific antigen; simple prostatectomy |
| المشرفين على المادة: |
EC 3.4.21.77 (Prostate-Specific Antigen) |
| تواريخ الأحداث: |
Date Created: 20230628 Date Completed: 20230907 Latest Revision: 20230911 |
| رمز التحديث: |
20230911 |
| DOI: |
10.1089/end.2023.0101 |
| PMID: |
37376750 |
| قاعدة البيانات: |
MEDLINE |
