دورية أكاديمية

Cysteinyl-leukotrienes promote cutaneous Leishmaniasis control.

التفاصيل البيبلوغرافية
العنوان: Cysteinyl-leukotrienes promote cutaneous Leishmaniasis control.
المؤلفون: Noronha LPT; Laboratory of Immunophysiology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Martins MDA; Laboratory of Immunophysiology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Castro-Junior AB; Laboratory of Immunophysiology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Thorstenberg ML; Laboratory of Immunophysiology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Costa-Soares L; Laboratory of Immunophysiology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Rangel TP; Laboratory of Immunophysiology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Carvalho-Gondim F; Laboratory of Immunopharmacology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Rossi-Bergmann B; Laboratory of Immunopharmacology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Savio LEB; Laboratory of Immunophysiology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Canetti CA; Laboratory of Inflammation, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil., Coutinho-Silva R; Laboratory of Immunophysiology, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
المصدر: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2023 Jun 12; Vol. 13, pp. 1192800. Date of Electronic Publication: 2023 Jun 12 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media SA
مواضيع طبية MeSH: Leishmaniasis, Cutaneous*/drug therapy , Leishmaniasis*/pathology, Mice ; Animals ; Mice, Inbred C57BL ; Leukotrienes/physiology ; Cysteine ; Leukotriene B4
مستخلص: Leishmaniasis is a neglected tropical parasitic disease with few approved medications. Cutaneous leishmaniasis (CL) is the most frequent form, responsible for 0.7 - 1.0 million new cases annually worldwide. Leukotrienes are lipid mediators of inflammation produced in response to cell damage or infection. They are subdivided into leukotriene B4 (LTB 4 ) and cysteinyl leukotrienes LTC4 and LTD4 (Cys-LTs), depending on the enzyme responsible for their production. Recently, we showed that LTB 4 could be a target for purinergic signaling controlling Leishmania amazonensis infection; however, the importance of Cys-LTs in the resolution of infection remained unknown. Mice infected with L. amazonensis are a model of CL infection and drug screening. We found that Cys-LTs control L. amazonensis infection in susceptible (BALB/c) and resistant (C57BL/6) mouse strains. In vitro , Cys-LTs significantly diminished the L. amazonensis infection index in peritoneal macrophages of BALB/c and C57BL/6 mice. In vivo , intralesional treatment with Cys-LTs reduced the lesion size and parasite loads in the infected footpads of C57BL/6 mice. The anti-leishmanial role of Cys-LTs depended on the purinergic P2X7 receptor, as infected cells lacking the receptor did not produce Cys-LTs in response to ATP. These findings suggest the therapeutic potential of LTB4 and Cys-LTs for CL treatment.
Competing Interests: The authors declare that the research was conducted without commercial or financial relationships that could be construed as potential conflicts of interest.
(Copyright © 2023 Noronha, Martins, Castro-Junior, Thorstenberg, Costa-Soares, Rangel, Carvalho-Gondim, Rossi-Bergmann, Savio, Canetti and Coutinho-Silva.)
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فهرسة مساهمة: Keywords: LTC4; LTD4; Leishmania amazonensis; P2X7; cutaneous leishmaniasis (CL); cysteinyl-leukotrienes
المشرفين على المادة: 0 (cysteinyl-leukotriene)
0 (Leukotrienes)
K848JZ4886 (Cysteine)
1HGW4DR56D (Leukotriene B4)
تواريخ الأحداث: Date Created: 20230628 Date Completed: 20230630 Latest Revision: 20230703
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10291179
DOI: 10.3389/fcimb.2023.1192800
PMID: 37377641
قاعدة البيانات: MEDLINE
الوصف
تدمد:2235-2988
DOI:10.3389/fcimb.2023.1192800