دورية أكاديمية
Factors influencing postoperative recurrence of early-stage non-small cell lung cancer.
| العنوان: | Factors influencing postoperative recurrence of early-stage non-small cell lung cancer. |
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| المؤلفون: | Akcam TI; Department of Thoracic Surgery, Ege University School of Medicine, İzmir, Turkey., Tekneci AK; Department of Thoracic Surgery, Health Sciences University İzmir Tepecik Education and Research Hospital, İzmir, Turkey., Ergin TM; Department of Thoracic Surgery, Ege University School of Medicine, İzmir, Turkey., Memmedov R; Department of Thoracic Surgery, Ege University School of Medicine, İzmir, Turkey., Ergonul AG; Department of Thoracic Surgery, Ege University School of Medicine, İzmir, Turkey., Ozdil A; Department of Thoracic Surgery, Ege University School of Medicine, İzmir, Turkey., Turhan K; Department of Thoracic Surgery, Ege University School of Medicine, İzmir, Turkey., Cakan A; Department of Thoracic Surgery, Ege University School of Medicine, İzmir, Turkey., Cagırıcı U; Department of Thoracic Surgery, Ege University School of Medicine, İzmir, Turkey. |
| المصدر: | Acta chirurgica Belgica [Acta Chir Belg] 2024 Apr; Vol. 124 (2), pp. 121-130. Date of Electronic Publication: 2023 Jul 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 0370571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0001-5458 (Print) Linking ISSN: 00015458 NLM ISO Abbreviation: Acta Chir Belg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : London : Taylor & Francis Original Publication: Bruxelles : Acta Medica Belgica |
| مواضيع طبية MeSH: | Carcinoma, Non-Small-Cell Lung*/surgery , Carcinoma, Non-Small-Cell Lung*/pathology , Lung Neoplasms* , Adenocarcinoma*/pathology , Carcinoma, Squamous Cell*/surgery , Carcinoma, Squamous Cell*/pathology, Humans ; Retrospective Studies ; Neoplasm Staging ; Prognosis ; Neoplasm Recurrence, Local/pathology ; Neoplasm Invasiveness/pathology |
| مستخلص: | Purpose: This study aims to explain the factors that may influence recurrence after surgical resection for early non-small cell lung cancer (NSCLC). Methods: A retrospective analysis was made of 302 patients who underwent lung resection for stage I-IIA NSCLC in our clinic between January 2014 and August 2021. Results: The recurrence rate was higher in patients with squamous cell carcinoma (SCC) than in those with adenocarcinoma (AC) ( p = 0.004). Disease-free survival (DFS) was shorter in SCC ( p = 0.004). According to histopathological subtypes, the presence of lymphovascular invasion (LVI), vascular invasion (VI), visceral pleural invasion (VPI) and tumor spread through air spaces (STAS) caused an increased risk of recurrence (( p = 0.004), ( p = 0.001), ( p = 0.047), ( p = < 0.001)) and shorter DFS (( p = 0.002), ( p = < 0.001), ( p = 0.038), ( p = < 0.001)). LVI and VI was more common in patients with distant recurrence ( p = 0.020, p = 0.002), while the STAS was more common with locoregional recurrence ( p = 0.003). Conclusion: The presence of LVI, VI, VPI, and STAS are negative risk factors for recurrence and DFS in all patients and in patients with AC. In patients with SCC, the diagnosis of SCC itself and the presence of STAS were risk factors for recurrence and DFS. Moreover, the risk of distant recurrence is higher in the presence of LVI or VI, and the risk of locoregional recurrence in the presence of STAS is higher. |
| فهرسة مساهمة: | Keywords: Non-small cell lung cancer; STAS; histopathology; recurrence; surgery; survival |
| تواريخ الأحداث: | Date Created: 20230629 Date Completed: 20240312 Latest Revision: 20240312 |
| رمز التحديث: | 20240312 |
| DOI: | 10.1080/00015458.2023.2231210 |
| PMID: | 37381717 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 0001-5458 |
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| DOI: | 10.1080/00015458.2023.2231210 |