دورية أكاديمية
أعرض في EDS

Acute-on-chronic liver failure is independently associated with higher mortality for cirrhotic patients with acute esophageal variceal hemorrhage: Retrospective cohort study.

التفاصيل البيبلوغرافية
العنوان: Acute-on-chronic liver failure is independently associated with higher mortality for cirrhotic patients with acute esophageal variceal hemorrhage: Retrospective cohort study.
المؤلفون: Terres AZ; Clinical Gastroenterology, Universidade de Caxias do Sul, Caxias do Sul 95020-002, Brazil., Balbinot RS; School of Medicine, Universidade de Caxias do Sul, Caxias do Sul 95020-002, Brazil., Muscope ALF; School of Medicine, Universidade de Caxias do Sul, Caxias do Sul 95020-002, Brazil., Longen ML; School of Medicine, Universidade de Caxias do Sul, Caxias do Sul 95020-002, Brazil., Schena B; School of Medicine, Universidade de Caxias do Sul, Caxias do Sul 95020-002, Brazil., Cini BT; School of Medicine, Universidade de Caxias do Sul, Caxias do Sul 95020-002, Brazil., Rost GL Jr; School of Medicine, Universidade de Caxias do Sul, Caxias do Sul 95020-002, Brazil., Balensiefer JIL; School of Medicine, Universidade de Caxias do Sul, Caxias do Sul 95020-002, Brazil., Eberhardt LZ; School of Medicine, Universidade de Caxias do Sul, Caxias do Sul 95020-002, Brazil., Balbinot RA; Clinical Gastroenterology, Universidade de Caxias do Sul, Caxias do Sul 95020-002, Brazil., Balbinot SS; Clinical Gastroenterology, Universidade de Caxias do Sul, Caxias do Sul 95020-002, Brazil., Soldera J; Department of Gastroenterology, University of South Wales, Cardiff CF37 1DL, United Kingdom. jonathansoldera@gmail.com.
المصدر: World journal of clinical cases [World J Clin Cases] 2023 Jun 16; Vol. 11 (17), pp. 4003-4018.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 101618806 Publication Model: Print Cited Medium: Print ISSN: 2307-8960 (Print) Linking ISSN: 23078960 NLM ISO Abbreviation: World J Clin Cases Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2014-: Pleasanton, CA : Baishideng Publishing Group
Original Publication: Hong Kong, China : Baishideng Publishing Group Co., Limited, [2013]-
مستخلص: Background: Acute esophageal variceal hemorrhage (AEVH) is a common complication of cirrhosis and might precipitate multi-organ failure, causing acute-on-chronic liver failure (ACLF).
Aim: To analyze if the presence and grading of ACLF as defined by European Society for the Study of the Liver-Chronic Liver Failure (EASL-CLIF) is able to predict mortality in cirrhotic patients presenting AEVH.
Methods: Retrospective cohort study executed in Hospital Geral de Caxias do Sul. Data from medical records from 2010 to 2016 were obtained by searching the hospital electronic database for patients who received terlipressin. Medical records were reviewed in order to determine the diagnosis of cirrhosis and AEVH, including 97 patients. Kaplan-Meier survival analysis was used for univariate analysis and a stepwise approach to the Cox regression for multivariate analysis.
Results: All- cause mortality for AEVH patients was 36%, 40.2% and 49.4% for 30-, 90- and 365-day, respectively. The prevalence of ACLF was 41.3%. Of these, 35% grade 1, 50% grade 2 and 15% grade 3. In multivariate analysis, the non-use of non-selective beta-blockers, presence and higher grading of ACLF and higher Model for End-Stage Liver Disease scores were independently associated with higher mortality for 30-day with the addition of higher Child-Pugh scores for 90-day period.
Conclusion: Presence and grading of ACLF according to the EASL-CLIF criteria was independently associated with higher 30- and 90-day mortality in cirrhotic patients admitted due to AEVH.
Competing Interests: Conflict-of-interest statement: The authors declare no conflict of interest.
(©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.)
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فهرسة مساهمة: Keywords: Acute-on-chronic liver failure; Esophageal and gastric varices; Gastrointestinal hemorrhage; Liver cirrhosis; Organ dysfunction scores; Prognosis
تواريخ الأحداث: Date Created: 20230630 Latest Revision: 20230703
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10303600
DOI: 10.12998/wjcc.v11.i17.4003
PMID: 37388802
قاعدة البيانات: MEDLINE
الوصف
تدمد:2307-8960
DOI:10.12998/wjcc.v11.i17.4003