دورية أكاديمية
Myelin oligodendrocyte glycoprotein antibody-associated disease preceding primary central nervous system lymphoma: causality or coincidence?
| العنوان: | Myelin oligodendrocyte glycoprotein antibody-associated disease preceding primary central nervous system lymphoma: causality or coincidence? |
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| المؤلفون: | Cai MT; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China., Lai QL; Department of Neurology, Zhejiang Hospital, Hangzhou, 310013, China., Tang JL; Department of Pathology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China., Du BQ; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China., Shen CH; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China., Zhang YX; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China. zyx-neurology@zju.edu.cn., Guo Y; Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China. yiguo@zju.edu.cn.; Department of General Practice and International Medicine, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, China. yiguo@zju.edu.cn. |
| المصدر: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2023 Oct; Vol. 44 (10), pp. 3711-3715. Date of Electronic Publication: 2023 Jun 30. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Italia Country of Publication: Italy NLM ID: 100959175 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1590-3478 (Electronic) Linking ISSN: 15901874 NLM ISO Abbreviation: Neurol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milano, Italy : Springer-Verlag Italia, c2000- |
| مواضيع طبية MeSH: | Brain*/pathology , Lymphoma*/complications, Humans ; Male ; Autoantibodies ; Myelin-Oligodendrocyte Glycoprotein ; Neuroimaging ; Spinal Cord ; Middle Aged |
| مستخلص: | Introduction: Primary central nervous system lymphoma (PCNSL) is a rare extranodal lymphomatous malignancy that affects the brain, spinal cord, leptomeninges, or eyes, in the absence of systemic diffusion. Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is a newly identified benign immune-mediated CNS inflammatory disorder with specific anti-MOG antibody seropositivity. These two seemingly unrelated nosological entities both have abundant clinical and radiological manifestations, and whether there is a potential link between them is unclear. Case Report: We describe a 49-year-old man who presented progressive headache, dizziness, and unsteady gait with multifocal scattered T2 hyperintensities with contrast enhancement. The serum anti-MOG antibody test was positive, and a brain biopsy showed inflammatory infiltration. Initially, he was diagnosed with MOGAD and his condition improved after corticosteroid therapy. The patient relapsed with exacerbation of symptoms and neuroimaging showed new mass-forming lesions four months later. A second brain biopsy confirmed PCNSL. Discussion: This is the first report of histologically confirmed successive MOGAD and PCNSL. Our case broadens the phenotypic spectrum of sentinel lesions in PCNSL. Though rare, PCNSL should be considered in patients diagnosed with benign CNS inflammatory disorder and responding well to steroid treatment when their clinical symptoms worsen and the imaging deteriorates. A timely biopsy is critical for accurate diagnosis and appropriate therapy. (© 2023. Fondazione Società Italiana di Neurologia.) |
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| فهرسة مساهمة: | Keywords: Biopsy; Myelin oligodendrocyte glycoprotein antibody-associated disease; Primary central nervous system lymphoma; Sentinel lesions |
| المشرفين على المادة: | 0 (Autoantibodies) 0 (Myelin-Oligodendrocyte Glycoprotein) |
| تواريخ الأحداث: | Date Created: 20230630 Date Completed: 20230915 Latest Revision: 20230922 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s10072-023-06919-1 |
| PMID: | 37389732 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1590-3478 |
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| DOI: | 10.1007/s10072-023-06919-1 |