دورية أكاديمية
Fluorinated 2-Azetines: Synthesis, Applications, Biological Tests, and Development of a Catalytic Process.
العنوان: | Fluorinated 2-Azetines: Synthesis, Applications, Biological Tests, and Development of a Catalytic Process. |
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المؤلفون: | Losa R; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France., Lorton C; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France., Retailleau P; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France., Bignon J; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France., Voituriez A; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France. |
المصدر: | Organic letters [Org Lett] 2023 Jul 14; Vol. 25 (27), pp. 5140-5144. Date of Electronic Publication: 2023 Jun 30. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Washington, DC : American Chemical Society, c1999- |
مواضيع طبية MeSH: | Azetines* , Phosphines*, Humans ; Carboxylic Acids ; Catalysis ; Benzoates/chemistry |
مستخلص: | An efficient and straightforward phosphine-promoted tandem aza-Michael addition/intramolecular Wittig reaction was developed for the synthesis of polyfunctionalized 2-azetines. After demonstrating that this transformation could be made catalytic in phosphine through in situ reduction of phosphine oxide with phenylsilane, different post-transformation steps have been demonstrated, including an original [2 + 2] photodimerization. Preliminary biological tests highlighted that these fluorinated 1,2-dihydroazete-2,3-dicarboxylates exhibited significant cytotoxicity against the human tumor cell line. |
المشرفين على المادة: | 0 (Azetines) 0 (Carboxylic Acids) FW6947296I (phosphine) 0 (Phosphines) 0 (Benzoates) |
تواريخ الأحداث: | Date Created: 20230630 Date Completed: 20230717 Latest Revision: 20231205 |
رمز التحديث: | 20240628 |
DOI: | 10.1021/acs.orglett.3c01888 |
PMID: | 37390327 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1523-7052 |
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DOI: | 10.1021/acs.orglett.3c01888 |