دورية أكاديمية
Gene expression alterations in the postmortem hippocampus from older patients with bipolar disorder - A hypothesis generating study.
| العنوان: | Gene expression alterations in the postmortem hippocampus from older patients with bipolar disorder - A hypothesis generating study. |
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| المؤلفون: | Nascimento C; Bipolar Disorder Program, Department of Psychiatry, University of Sao Paulo Medical School, SP, Brazil; Department of Psychiatry, University of Sao Paulo Medical School, SP, Brazil. Electronic address: camilanascimentomantelli@gmail.com., Kyunghee Kim H; Department of Psychiatry, University of Toronto, ON, Canada. Electronic address: helenakim0913@gmail.com., Villela Nunes P; Bipolar Disorder Program, Department of Psychiatry, University of Sao Paulo Medical School, SP, Brazil; Department of Psychiatry, University of Sao Paulo Medical School, SP, Brazil. Electronic address: paulavillelanunes@gmail.com., Paraiso Leite RE; Division of Geriatrics, University of Sao Paulo Medical School, SP, Brazil. Electronic address: renata.leite@hc.fm.usp.br., Katia Cristina O; Federal University of ABC, Sao Bernardo do Campo, SP, Brazil. Electronic address: kcristinaoliveira@gmail.com., Barbosa A; Department of Psychiatry, University of Sao Paulo Medical School, SP, Brazil. Electronic address: andrecode20@gmail.com., Bernardi Bertonha F; Department of Pediatrics, Faculdade de Medicina da Universidade de São Paulo, SP, Brazil. Electronic address: fernanda.bernardi@fm.usp.br., Moreira-Filho CA; Department of Pediatrics, Faculdade de Medicina da Universidade de São Paulo, SP, Brazil. Electronic address: cmoreira@usp.br., Jacob-Filho W; Division of Geriatrics, University of Sao Paulo Medical School, SP, Brazil. Electronic address: wiljac@usp.br., Nitrini R; Department of Neurology, University of Sao Paulo Medical School, SP, Brazil. Electronic address: rnitrini@uol.com.br., Pasqualucci CA; Department of Pathology, University of Sao Paulo Medical School, SP, Brazil. Electronic address: cpasqua@usp.br., Tenenholz Grinberg L; Department of Pathology, University of Sao Paulo Medical School, SP, Brazil; Memory and Aging Center University of California, San Francisco, USA. Electronic address: Lea.Grinberg@ucsf.edu., Kimie Suemoto C; Division of Geriatrics, University of Sao Paulo Medical School, SP, Brazil. Electronic address: cksuemoto@usp.br., Brentani HP; Department of Psychiatry, University of Sao Paulo Medical School, SP, Brazil. Electronic address: helena.brentani@gmail.com., Lafer B; Bipolar Disorder Program, Department of Psychiatry, University of Sao Paulo Medical School, SP, Brazil; Department of Psychiatry, University of Sao Paulo Medical School, SP, Brazil. Electronic address: blafer@usp.br. |
| المصدر: | Journal of psychiatric research [J Psychiatr Res] 2023 Aug; Vol. 164, pp. 329-334. Date of Electronic Publication: 2023 Jun 15. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford : Pergamon Press |
| مواضيع طبية MeSH: | Bipolar Disorder*/genetics , Bipolar Disorder*/metabolism, Humans ; Female ; Aged ; Middle Aged ; Male ; Microarray Analysis ; Gene Expression Regulation ; Gene Expression/genetics ; Hippocampus/metabolism |
| مستخلص: | Bipolar disorder (BD) presents with a progressive course in a subset of patients. However, our knowledge of molecular changes in older BD is limited. In this study, we examined gene expression changes in the hippocampus of BD from the Biobank of Aging Studies to identify genes of interest that warrant further exploration. RNA was extracted from the hippocampus from 11 subjects with BD and 11 age and sex-matched controls. Gene expression data was generated using the SurePrint G3 Human Gene Expression v3 microarray. Rank feature selection was performed to identify a subset of features that can optimally differentiate BD and controls. Genes ranked in the top 0.1% with log Competing Interests: Declaration of competing interest None. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Bipolar disorder; Gene expression; Hippocampus; Postmortem brain; Transcriptome |
| تواريخ الأحداث: | Date Created: 20230702 Date Completed: 20230719 Latest Revision: 20230720 |
| رمز التحديث: | 20230720 |
| DOI: | 10.1016/j.jpsychires.2023.06.002 |
| PMID: | 37393798 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1879-1379 |
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| DOI: | 10.1016/j.jpsychires.2023.06.002 |