دورية أكاديمية
Long non-coding RNA in coronary artery disease: the role of PDXDC1-AS1 and SFI1-AS1.
| العنوان: | Long non-coding RNA in coronary artery disease: the role of PDXDC1-AS1 and SFI1-AS1. |
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| المؤلفون: | He S; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, Jiangsu Province, China., Zhang S; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, Jiangsu Province, China., Wang YJ; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, Jiangsu Province, China., Gan XK; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, Jiangsu Province, China., Chen JX; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, Jiangsu Province, China., Zhou HX; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, Jiangsu Province, China., Jia EZ; Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300, Nanjing, 210029, Jiangsu Province, China. enzhijia@njmu.edu.cn. |
| المصدر: | Functional & integrative genomics [Funct Integr Genomics] 2023 Jul 03; Vol. 23 (3), pp. 219. Date of Electronic Publication: 2023 Jul 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 100939343 Publication Model: Electronic Cited Medium: Internet ISSN: 1438-7948 (Electronic) Linking ISSN: 1438793X NLM ISO Abbreviation: Funct Integr Genomics Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer, c2000- |
| مواضيع طبية MeSH: | RNA, Long Noncoding*/metabolism , Coronary Artery Disease*/genetics , Coronary Artery Disease*/diagnosis, Humans ; Leukocytes, Mononuclear/metabolism ; Biomarkers/metabolism ; Transcriptome |
| مستخلص: | This study investigates the interaction between long non-coding RNAs (lncRNAs) and metabolic risk factors that contribute to coronary artery disease (CAD). A total transcriptome high throughput sequencing study was conducted on peripheral blood mononuclear cells from five patients with CAD and five healthy controls. Validation assay by qRT-PCR was conducted among 270 patients and 47 controls. Finally, to evaluate the lncRNAs' diagnostic value for CAD, the Spearman correlation test and receiver operating characteristic curve (ROC) analysis were utilized. Additionally, univariate and multivariate logistic regression along with crossover analyses were conducted to identify the interaction between lncRNA and environmental risk factors. A total of 2149 of 26,027 lncRNAs identified by RNA sequencing were differentially expressed in CAD patients compared to controls. Validation by qRT-PCR showed significantly different relative expression levels for lncRNAs PDXDC1-AS1, SFI1-AS1, RP13-143G15.3, DAPK1-IT1, PPIE-AS1, and RP11-362A1.1 between the two groups (all P<0.05). The area under the ROC values of PDXDC1-AS1 and SFI1-AS1 is 0.645 (sensitivity=0.443 and specificity=0.920) and 0.629 (sensitivity=0.571 and specificity=0.909), especially. Multivariate logistic regression analyses showed that lncRNAs PDXDC1-AS1 (OR=2.285, 95%CI=1.390-3.754, p=0.001) and SFI1-AS1 (OR=1.163, 95%CI=1.163-2.264, p=0.004) were protective factors against CAD. Under the additive model, cross-over analyses demonstrated significant interactions between lncRNAs PDXDC1-AS1 and smoking in relation to CAD risk (S=3.871, 95%CI=1.140-6.599). PDXDC1-AS1 and SFI1-AS1 were sensitive and specific biomarkers for CAD and exhibited synergistic effects with certain environmental factors. These results highlighted their potential use as CAD diagnostic biomarkers for future research. (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Coronary artery disease; Crossover analysis; Peripheral Blood mononuclear cells; RNA-seq; lncRNA |
| المشرفين على المادة: | 0 (RNA, Long Noncoding) 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20230702 Date Completed: 20230704 Latest Revision: 20230704 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s10142-023-01134-9 |
| PMID: | 37394483 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1438-7948 |
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| DOI: | 10.1007/s10142-023-01134-9 |