دورية أكاديمية
Two new anti-inflammatory compounds from the roots and rhizomes of Clematis terniflora var . manshurica (Rupr.) Ohwi.
| العنوان: | Two new anti-inflammatory compounds from the roots and rhizomes of Clematis terniflora var . manshurica (Rupr.) Ohwi. |
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| المؤلفون: | Shao P; Department of Pharmaceutical Botany and Authentication of TCM, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.; Research and Development Center, NERC for the Pharmaceutics of Traditional Chinese Medicines, Benxi, China., Dong S; Department of Pharmaceutical Botany and Authentication of TCM, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China., Mu LT; Department of Pharmaceutical Botany and Authentication of TCM, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China., Han L; Research and Development Center, NERC for the Pharmaceutics of Traditional Chinese Medicines, Benxi, China., Lv CN; Department of Pharmaceutical Botany and Authentication of TCM, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China., Yuan JZ; Department of Pharmaceutical Botany and Authentication of TCM, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China., Lu JC; Department of Pharmaceutical Botany and Authentication of TCM, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China. |
| المصدر: | Natural product research [Nat Prod Res] 2024 Jun; Vol. 38 (11), pp. 1874-1881. Date of Electronic Publication: 2023 Jul 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Clematis*/chemistry , Rhizome*/chemistry , Plant Roots*/chemistry , Anti-Inflammatory Agents*/pharmacology , Anti-Inflammatory Agents*/chemistry , Anti-Inflammatory Agents*/isolation & purification , Nitric Oxide* , Lipopolysaccharides*/pharmacology , Tumor Necrosis Factor-alpha*/metabolism, Animals ; Mice ; RAW 264.7 Cells ; Molecular Structure ; Lignans/pharmacology ; Lignans/chemistry ; Lignans/isolation & purification ; Macrophages/drug effects ; Magnetic Resonance Spectroscopy |
| مستخلص: | Two new compounds named mandshurica A ( 1 ) and mandshurica B ( 2 ), together with four known lignans ( 3 - 6 ) were isolated from the roots and rhizomes of Clematis terniflora var. manshurica (Rupr.) Ohwi. The structures of the new compounds were elucidated by HR-ESI-MS, 1D and 2D NMR spectroscopy. Moreover, the anti-inflammatory activity of compounds 1 and 2 were evaluated against lipopolysaccharide-induced mouse macrophage RAW264.7 cells. Compounds 1 and 2 displayed significant inhibitory effect on NO production, and compound 2 exhibited obvious inhibition on the pro-inflammatory cytokines TNF-α. Both new compounds showed potential anti-inflammatory activity. |
| فهرسة مساهمة: | Keywords: Clematis terniflora var. manshurica (Rupr.) Ohwi; anti-inflammatory activity; chemical composition |
| المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 31C4KY9ESH (Nitric Oxide) 0 (Lipopolysaccharides) 0 (Tumor Necrosis Factor-alpha) 0 (Lignans) |
| تواريخ الأحداث: | Date Created: 20230703 Date Completed: 20240513 Latest Revision: 20240513 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1080/14786419.2023.2227912 |
| PMID: | 37395431 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2023.2227912 |