دورية أكاديمية

Formulation of Piperine-Loaded Nanoemulsion: In Vitro Characterization, Ex Vivo Evaluation, and Cell Viability Assessment.

التفاصيل البيبلوغرافية
العنوان: Formulation of Piperine-Loaded Nanoemulsion: In Vitro Characterization, Ex Vivo Evaluation, and Cell Viability Assessment.
المؤلفون: Alshehri S; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Bukhari SI; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Imam SS; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Hussain A; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Alghaith AF; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Altamimi MA; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., AlAbdulkarim AS; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Almurshedi A; Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
المصدر: ACS omega [ACS Omega] 2023 Jun 15; Vol. 8 (25), pp. 22406-22413. Date of Electronic Publication: 2023 Jun 15 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Washington, D.C. : American Chemical Society, [2016]-
مستخلص: Piperine is an alkaloid, but its therapeutic efficacy is limited due to poor aqueous solubility. In this study, piperine nanoemulsions were prepared using oleic acid (oil), Cremophore EL (surfactant), and Tween 80 (co-surfactant) using the high-energy ultrasonication approach. The optimal nanoemulsion (N2) was further evaluated using transmission electron microscopy, release, permeation, antibacterial, and cell viability studies based on minimal droplet size and maximum encapsulation efficiency. The prepared nanoemulsions (N1-N6) showed a transmittance of more than 95%, a mean droplet size between 105 ± 4.11 and 250 ± 7.4 nm, a polydispersity index of 0.19 to 0.36, and a ζ potential of -19 to -39 mV. The optimized nanoemulsion (N2) showed significantly improved drug release and permeation compared with pure piperine dispersion. The nanoemulsions were stable in the tested media. The transmission electron microscopy image showed a spherical and dispersed nanoemulsion droplet. The antibacterial and cell line results of piperine nanoemulsions were significantly better than the pure piperine dispersion. The findings suggested that piperine nanoemulsions may be a more advanced nanodrug delivery system than conventional ones.
Competing Interests: The authors declare no competing financial interest.
(© 2023 The Authors. Published by American Chemical Society.)
References: Int J Nanomedicine. 2014;9:1-15. (PMID: 24363556)
Colloids Surf B Biointerfaces. 2017 Jun 1;154:10-20. (PMID: 28284054)
Arthritis Res Ther. 2009;11(2):R49. (PMID: 19327174)
Drug Deliv. 2022 Dec;29(1):600-612. (PMID: 35174738)
Eur J Pharm Sci. 2019 Jan 15;127:115-120. (PMID: 30393196)
Mol Carcinog. 2015 Oct;54(10):1070-85. (PMID: 24819444)
Drug Deliv. 2021 Dec;28(1):1478-1495. (PMID: 34254539)
EMBO Rep. 2009 Mar;10(3):194-200. (PMID: 19229284)
Appl Biochem Biotechnol. 2022 Aug;194(8):3733-3748. (PMID: 35507250)
Artif Cells Nanomed Biotechnol. 2015;43(5):334-44. (PMID: 24641773)
Ther Deliv. 2020 Dec;11(12):767-778. (PMID: 33225842)
Cancer Lett. 2015 Feb 1;357(1):129-140. (PMID: 25444919)
Ultrason Sonochem. 2017 Jan;34:173-182. (PMID: 27773233)
Saudi Pharm J. 2021 Nov;29(11):1278-1288. (PMID: 34819790)
Eur J Cancer. 2018 Nov;103:356-387. (PMID: 30100160)
J Control Release. 2018 Jan 28;270:203-225. (PMID: 29199062)
Front Chem. 2022 Jun 22;10:904973. (PMID: 35815210)
Int J Bacteriol. 2014;2014:175851. (PMID: 26904730)
Int J Pharm. 2013 Sep 15;454(1):462-71. (PMID: 23830765)
Iran J Pharm Res. 2014 Fall;13(4):1125-40. (PMID: 25587300)
Biotechnol Adv. 2015 Dec;33(8):1582-1614. (PMID: 26281720)
Pharmaceutics. 2022 Jan 15;14(1):. (PMID: 35057093)
Fitoterapia. 2003 Feb;74(1-2):109-15. (PMID: 12628402)
Drug Deliv. 2016 Jul;23(6):2026-34. (PMID: 27187792)
Int J Mol Med. 2015 Nov;36(5):1369-76. (PMID: 26648012)
Mol Cell Biochem. 2012 Aug;367(1-2):73-84. (PMID: 22669728)
Ultrason Sonochem. 2012 Jan;19(1):192-7. (PMID: 21680223)
J Biomed Mater Res B Appl Biomater. 2020 Apr;108(3):717-728. (PMID: 31187938)
Int J Mol Sci. 2018 Dec 21;20(1):. (PMID: 30577587)
Int J Cancer. 2007 Jun 15;120(12):2600-8. (PMID: 17304514)
Nanomaterials (Basel). 2020 Apr 28;10(5):. (PMID: 32353979)
AAPS PharmSciTech. 2018 Feb;19(2):923-933. (PMID: 29071656)
Food Chem Toxicol. 2017 Jul;105:106-118. (PMID: 28341137)
Drug Dev Ind Pharm. 2017 Jun;43(6):1003-1010. (PMID: 28161984)
Food Chem. 2013 Dec 1;141(3):2591-9. (PMID: 23870999)
Antioxidants (Basel). 2022 Apr 25;11(5):. (PMID: 35624695)
Drug Deliv. 2021 Dec;28(1):1150-1165. (PMID: 34121561)
Eur J Pharm Sci. 2019 Sep 1;137:104988. (PMID: 31291598)
Nanomedicine (Lond). 2016 Nov;11(22):3009-3032. (PMID: 27781558)
Pharmaceutics. 2020 Jan 16;12(1):. (PMID: 31963155)
تواريخ الأحداث: Date Created: 20230703 Latest Revision: 20230704
رمز التحديث: 20230704
مُعرف محوري في PubMed: PMC10308402
DOI: 10.1021/acsomega.2c08187
PMID: 37396261
قاعدة البيانات: MEDLINE
الوصف
تدمد:2470-1343
DOI:10.1021/acsomega.2c08187