دورية أكاديمية
The Impact of Human Mammary Tumor Virus (HMTV) on the Expression of Epidermal Growth Factor Receptor (EGFR) and Death-Domain Associated Protein (DAXX) in Breast Carcinoma Tissues.
| العنوان: | The Impact of Human Mammary Tumor Virus (HMTV) on the Expression of Epidermal Growth Factor Receptor (EGFR) and Death-Domain Associated Protein (DAXX) in Breast Carcinoma Tissues. |
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| المؤلفون: | Ali Naeem H; Department of Pathology and Forensic, College of Medicine, University of Basrah, Basrah, Iraq., Nazar Ibraheim W; Department of Pathology and Forensic, College of Medicine, University of Basrah, Basrah, Iraq., Abdullah Alomar SA; Department of Pathology and Forensic, College of Medicine, University of Basrah, Basrah, Iraq. |
| المصدر: | Archives of Razi Institute [Arch Razi Inst] 2023 Apr 30; Vol. 78 (2), pp. 689-699. Date of Electronic Publication: 2023 Apr 30 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Razi Vaccine and Serum Research Institute Country of Publication: Iran NLM ID: 101549567 Publication Model: eCollection Cited Medium: Internet ISSN: 2008-9872 (Electronic) Linking ISSN: 03653439 NLM ISO Abbreviation: Arch Razi Inst Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2006- : Karaj, Iran : Razi Vaccine and Serum Research Institute Original Publication: 1999-2005 : Tehran, Iran : Razi Vaccine and Serum Research Institute |
| مواضيع طبية MeSH: | Triple Negative Breast Neoplasms* , Betaretrovirus*, Humans ; Female ; Retrospective Studies ; Immunohistochemistry ; Case-Control Studies ; Molecular Chaperones ; Co-Repressor Proteins ; ErbB Receptors |
| مستخلص: | The presence and characteristics of HMTV in Iraqi breast cancer women are still unknown. Furthermore, the identification of HMTV in human breast carcinoma tissue of patients differs by country, and the factors that influence it are still unknown. In many epithelial tumor types, the EGFR and its signaling pathways outcomes are necessary for the behavior of cells and regulating their proliferation, and it has been discovered that DAXX has strong carcinogenic characteristics and could be a new treatment target. This case-control retrospective study investigated the presence of HMTV in paraffin-embedded blocks (FFPT) of tumor samples from 60 Iraqi women patients diagnosed with primary breast cancer and 20 cases of benign tumors as a control group. HMTV env sequences were identified by Real-time PCR. EGFR and DAXX expression were immun0-detected by the immuno-histochemistry technique. HMTV sequences were detected in 15 (25%) samples of malignant breast tumors and 8 (40%) samples of benign breast tumors. There was no statistically significant association between the detection of env sequences of HMTV and age, grade, hormone receptors, EGFR, or DAXX expression compared to clinicopathological characteristics. However, statistically, the data showed a highly significant difference in the Expression of EGFR between study groups, age, and histological types ( P =0.0001), and a significant negative association was observed between EGFR and both Her2 and TNBC. There was a statistically significant difference between DAXX (+) and DAXX (-) in study groups ( P =0.002), and it was significantly associated with age and histological types of breast cancer ( P =0.031 and 0.007, respectively). No significant association was found between DAXX and EGFR, grade, Her2. TNBC of breast cancer. The current study found HMTV env sequences in breast tumors of Iraqi women, suggesting that a larger sample size is needed to illustrate the potential causative role of HMTV in the development of human breast malignancy. Moreover, a negative association was found between HMTV and DAXX and EGFR Expression. Competing Interests: The authors declare that they have no conflict of interest. |
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| فهرسة مساهمة: | Keywords: Breast cancer; DAXX; EGFR; HMTV |
| المشرفين على المادة: | 0 (DAXX protein, human) 0 (Molecular Chaperones) 0 (Co-Repressor Proteins) EC 2.7.10.1 (EGFR protein, human) EC 2.7.10.1 (ErbB Receptors) |
| تواريخ الأحداث: | Date Created: 20230703 Date Completed: 20230705 Latest Revision: 20230705 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10314243 |
| DOI: | 10.22092/ARI.2022.359520.2440 |
| PMID: | 37396746 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2008-9872 |
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| DOI: | 10.22092/ARI.2022.359520.2440 |