دورية أكاديمية
Apical-basal polarity of the spectrin cytoskeleton in the C. elegans vulva.
| العنوان: | Apical-basal polarity of the spectrin cytoskeleton in the C. elegans vulva. |
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| المؤلفون: | Barker TJ; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States., Chan FY; i3S-Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.; IBMC-Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal., Carvalho AX; IBMC-Instituto de Biologia Molecular e Celular, University of Porto, Porto, Portugal.; i3S-Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal., Sundaram MV; Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States. |
| المصدر: | MicroPublication biology [MicroPubl Biol] 2023 Jun 14; Vol. 2023. Date of Electronic Publication: 2023 Jun 14 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Caltech Library Country of Publication: United States NLM ID: 101759238 Publication Model: eCollection Cited Medium: Internet ISSN: 2578-9430 (Electronic) Linking ISSN: 25789430 NLM ISO Abbreviation: MicroPubl Biol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Pasadena, CA : Caltech Library, [2016]- |
| مستخلص: | The C. elegans vulva is a polarized epithelial tube that has been studied extensively as a model for cell-cell signaling, cell fate specification, and tubulogenesis. Here we used endogenous fusions to show that the spectrin cytoskeleton is polarized in this organ, with conventional beta-spectrin ( UNC-70 ) found only at basolateral membranes and beta heavy spectrin ( SMA-1 ) found only at apical membranes. The sole alpha-spectrin ( SPC-1 ) is present at both locations but requires SMA-1 for its apical localization. Thus, beta spectrins are excellent markers for vulva cell membranes and polarity. Competing Interests: The authors declare that there are no conflicts of interest present. (Copyright: © 2023 by the authors.) |
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| معلومات مُعتمدة: | R35 GM136315 United States GM NIGMS NIH HHS |
| تواريخ الأحداث: | Date Created: 20230703 Latest Revision: 20240411 |
| رمز التحديث: | 20240411 |
| مُعرف محوري في PubMed: | PMC10308243 |
| DOI: | 10.17912/micropub.biology.000863 |
| PMID: | 37396793 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2578-9430 |
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| DOI: | 10.17912/micropub.biology.000863 |