التفاصيل البيبلوغرافية
| العنوان: |
Alcohol inhibits sociability via serotonin inputs to the nucleus accumbens. |
| المؤلفون: |
Wang R, Khan KM, Balasubramanian N, James T, Pushpavathi SG, Kim D, Pierson S, Wu Q, Niciu MJ, Hefti MM, Marcinkiewcz CA |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2023 May 30. Date of Electronic Publication: 2023 May 30. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
Social interaction is a core component of motivational behavior that is perturbed across multiple neuropsychiatric disorders, including alcohol use disorder (AUD). Positive social bonds are neuroprotective and enhance recovery from stress, so reduced social interaction in AUD may delay recovery and lead to alcohol relapse. We report that chronic intermittent ethanol (CIE) induces social avoidance in a sex-dependent manner and is associated with hyperactivity of serotonin (5-HT) neurons in the dorsal raphe nucleus (DRN). While 5-HT DRN neurons are generally thought to enhance social behavior, recent evidence suggests that specific 5-HT pathways can be aversive. Using chemogenetic iDISCO, the nucleus accumbens (NAcc) was identified as one of 5 regions that were activated by 5-HT DRN stimulation. We then employed an array of molecular genetic tools in transgenic mice to show that 5-HT DRN inputs to NAcc dynorphin neurons drive social avoidance in male mice after CIE by activating 5-HT 2C receptors. NAcc dynorphin neurons also inhibit dopamine release during social interaction, reducing the motivational drive to engage with social partners. This study reveals that excessive serotonergic drive after chronic alcohol can promote social aversion by inhibiting accumbal dopamine release. Drugs that boost brain serotonin levels may be contraindicated for individuals with AUD. |
| معلومات مُعتمدة: |
R00 AA024142 United States AA NIAAA NIH HHS |
| تواريخ الأحداث: |
Date Created: 20230703 Latest Revision: 20230902 |
| رمز التحديث: |
20230902 |
| مُعرف محوري في PubMed: |
PMC10312479 |
| DOI: |
10.1101/2023.05.29.542761 |
| PMID: |
37398335 |
| قاعدة البيانات: |
MEDLINE |
