Intrinsic Homeostatic Plasticity in Mouse and Human Sensory Neurons.
| العنوان: | Intrinsic Homeostatic Plasticity in Mouse and Human Sensory Neurons. |
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| المؤلفون: | McIlvried LA; Washington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA.; These authors contributed equally., Del Rosario JS; Washington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA.; These authors contributed equally., Pullen MY; Washington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA., Wangzhou A; Department of Neuroscience and Center for Advanced Pain Studies; The University of Texas at Dallas; Dallas, TX, 75080; USA., Sheahan TD; Washington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA., Shepherd AJ; Washington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA., Slivicki RA; Washington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA., Lemen JA; Mid-American Transplant; St. Louis, MO, 63110; USA., Price TJ; Department of Neuroscience and Center for Advanced Pain Studies; The University of Texas at Dallas; Dallas, TX, 75080; USA., Copits BA; Washington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA., Gereau RW 4th; Washington University Pain Center and Department of Anesthesiology; Washington University School of Medicine; St. Louis, MO, 63110; USA.; Department of Neuroscience and Department of Biomedical Engineering; Washington University School of Medicine; St. Louis, MO, 63110; USA.; Lead contact. |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 14. Date of Electronic Publication: 2023 Jun 14. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | In response to changes in activity induced by environmental cues, neurons in the central nervous system undergo homeostatic plasticity to sustain overall network function during abrupt changes in synaptic strengths. Homeostatic plasticity involves changes in synaptic scaling and regulation of intrinsic excitability. Increases in spontaneous firing and excitability of sensory neurons are evident in some forms of chronic pain in animal models and human patients. However, whether mechanisms of homeostatic plasticity are engaged in sensory neurons under normal conditions or altered after chronic pain is unknown. Here, we showed that sustained depolarization induced by 30mM KCl induces a compensatory decrease in the excitability in mouse and human sensory neurons. Moreover, voltage-gated sodium currents are robustly reduced in mouse sensory neurons contributing to the overall decrease in neuronal excitability. Decreased efficacy of these homeostatic mechanisms could potentially contribute to the development of the pathophysiology of chronic pain. Competing Interests: DECLARATION OF INTEREST The authors declare no competing interest |
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| معلومات مُعتمدة: | U19 NS130607 United States NS NINDS NIH HHS; F99 NS113422 United States NS NINDS NIH HHS; K00 NS113422 United States NS NINDS NIH HHS; R01 NS042595 United States NS NINDS NIH HHS; L70 NS129038 United States NS NINDS NIH HHS; R01 NS065926 United States NS NINDS NIH HHS; T32 DA007261 United States DA NIDA NIH HHS; U19 NS130608 United States NS NINDS NIH HHS |
| فهرسة مساهمة: | Keywords: Depolarization; Excitability; Homeostatic Plasticity; Sensory neurons; voltage-gated sodium channels |
| تواريخ الأحداث: | Date Created: 20230703 Latest Revision: 20240612 |
| رمز التحديث: | 20240612 |
| مُعرف محوري في PubMed: | PMC10312743 |
| DOI: | 10.1101/2023.06.13.544829 |
| PMID: | 37398430 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2023.06.13.544829 |
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