دورية أكاديمية
Sex-specific regulation of prolactin secretion by pituitary activins in postnatal development.
| العنوان: | Sex-specific regulation of prolactin secretion by pituitary activins in postnatal development. |
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| المؤلفون: | Abeledo-Machado A; Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Bornancini D; Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Peña-Zanoni M; Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Camilletti MA; Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Faraoni EY; Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina., Díaz-Torga G; Instituto de Biología y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina. |
| المصدر: | The Journal of endocrinology [J Endocrinol] 2023 Aug 02; Vol. 258 (3). Date of Electronic Publication: 2023 Aug 02 (Print Publication: 2023). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioScientifica Country of Publication: England NLM ID: 0375363 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1479-6805 (Electronic) Linking ISSN: 00220795 NLM ISO Abbreviation: J Endocrinol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Bristol, UK : BioScientifica Original Publication: Bristol, UK : Society for Endocrinology |
| مواضيع طبية MeSH: | Prolactin*/metabolism , Lactotrophs*/metabolism, Female ; Rats ; Male ; Animals ; Activins/metabolism ; Rats, Sprague-Dawley ; Pituitary Gland/metabolism ; Transcription Factors/metabolism |
| مستخلص: | Serum prolactin increases from birth to adulthood in rats, being higher in females from birth. The maturation of hypothalamic/gonadal prolactin-releasing and -inhibiting factors does not explain some sex differences observed. During the first weeks of life, prolactin secretion increases, even when lactotrophs are isolated in vitro, in the absence of those controls, suggesting the participation of intra-pituitary factors in this control. The present work aimed to study the involvement of pituitary activins in the regulation of prolactin secretion during post-natal development. Sex differences were also highlighted. Female and male Sprague-Dawley rats at 11, 23 and 45postnatal days were used. Pituitary expression of activin subunits and activin receptors was maximum in p11 female pituitaries, being even higher than that observed in males. Those expressions decrease with age in females, and then the gender differences disappear at p23. Inhbb expression strongly increases at p45 in males, being the predominant subunit in this sex in adulthood. Activin inhibition of prolactin is mediated by the inhibition of Pit-1 expression. This action involves not only the canonical pSMAD pathway but also the phosphorylation of p38MAPK. At p11, almost all lactotrophs express p-p38MAPK in females, and its expression decreases with age with a concomitant increase in Pit-1. Our findings suggest that the inhibitory regulation of pituitary activins on prolactin secretion is sex specific; this regulation is more relevant in females during the first week of life and decreases with age; this intra-pituitary regulation is involved in the sex differences observed in serum prolactin levels during postnatal development. |
| فهرسة مساهمة: | Keywords: activins; lactotrophs; postnatal development; prolactin; sex differences |
| المشرفين على المادة: | 9002-62-4 (Prolactin) 104625-48-1 (Activins) 0 (Transcription Factors) |
| تواريخ الأحداث: | Date Created: 20230703 Date Completed: 20230803 Latest Revision: 20231103 |
| رمز التحديث: | 20240514 |
| DOI: | 10.1530/JOE-23-0020 |
| PMID: | 37399522 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1479-6805 |
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| DOI: | 10.1530/JOE-23-0020 |