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An electric field modeling study with meta-analysis to understand the antidepressant effects of transcranial direct current stimulation (tDCS).

التفاصيل البيبلوغرافية
العنوان: An electric field modeling study with meta-analysis to understand the antidepressant effects of transcranial direct current stimulation (tDCS).
المؤلفون: Razza LB; Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium. Ghent Experimental Psychiatry Lab, Ghent, Belgium., Wischnewski M; Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA., Suen P; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências, Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil., De Smet S; Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium. Ghent Experimental Psychiatry Lab, Ghent, Belgium., da Silva PHR; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências, Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil., Catoira B; Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium. Ghent Experimental Psychiatry Lab, Ghent, Belgium. Department of Psychiatry, Free University Brussels, Ixelles, Belgium., Brunoni AR; Serviço Interdisciplinar de Neuromodulação, Laboratório de Neurociências, Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil. Departamento de Clínica Médica, Hospital das Clínicas, Faculdade de Medicina, USP, São Paulo, SP, Brazil. Hospital das Clínicas, USP, São Paulo, SP, Brazil., Vanderhasselt MA; Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium. Ghent Experimental Psychiatry Lab, Ghent, Belgium.
المصدر: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) [Braz J Psychiatry] 2023 Nov-Dec; Vol. 45 (6), pp. 518-529. Date of Electronic Publication: 2023 Jul 03.
نوع المنشور: Meta-Analysis; Journal Article
اللغة: English
بيانات الدورية: Publisher: Associação Brasileira de Psiquiatria Country of Publication: Brazil NLM ID: 100895975 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1809-452X (Electronic) Linking ISSN: 15164446 NLM ISO Abbreviation: Braz J Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Original Publication: São Paulo, SP, Brasil : Associação Brasileira de Psiquiatria, [1999]-
مواضيع طبية MeSH: Transcranial Direct Current Stimulation*/methods , Depressive Disorder, Major*/therapy, Humans ; Prefrontal Cortex ; Brain ; Antidepressive Agents
مستخلص: Objective: Transcranial direct current stimulation (tDCS) has mixed effects for major depressive disorder (MDD) symptoms, partially owing to large inter-experimental variability in tDCS protocols and their correlated induced electric fields (E-fields). We investigated whether the E-field strength of distinct tDCS parameters was associated with antidepressant effect.
Methods: A meta-analysis was performed with placebo-controlled clinical trials of tDCS enrolling MDD patients. PubMed, EMBASE, and Web of Science were searched from inception to March 10, 2023. Effect sizes of tDCS protocols were correlated with E-field simulations (SimNIBS) of brain regions of interest (bilateral dorsolateral prefrontal cortex [DLPFC] and bilateral subgenual anterior cingulate cortex [sgACC]). Moderators of tDCS responses were also investigated.
Results: A total of 20 studies were included (21 datasets, 1,008 patients), using 11 distinct tDCS protocols. Results revealed a moderate effect for MDD (g = 0.41, 95%CI 0.18-0.64), while cathode position and treatment strategy were found to be moderators of response. A negative association between effect size and tDCS-induced E-field magnitude was seen, with stronger E-fields in the right frontal and medial parts of the DLPFC (targeted by the cathode) leading to smaller effects. No association was found for the left DLPFC and the bilateral sgACC. An optimized tDCS protocol is proposed.
Conclusion: Our results highlight the need for a standardized tDCS protocol in MDD clinical trials.
Competing Interests: ARB has a small equity stake in Flowt, whose devices were not used in the present study. The other authors report no conflicts of interest.
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فهرسة مساهمة: Keywords: Transcranial direct current stimulation; computational modeling analysis; depression; dorsolateral prefrontal cortex; electric field; major depressive disorder; meta-analysis; subgenual anterior cingulate cortex
المشرفين على المادة: 0 (Antidepressive Agents)
تواريخ الأحداث: Date Created: 20230703 Date Completed: 20240228 Latest Revision: 20240229
رمز التحديث: 20240229
مُعرف محوري في PubMed: PMC10897770
DOI: 10.47626/1516-4446-2023-3116
PMID: 37400373
قاعدة البيانات: MEDLINE
الوصف
تدمد:1809-452X
DOI:10.47626/1516-4446-2023-3116