دورية أكاديمية
Higher CD4 + CD40 + T cells (Th40 cells) associate with systemic lupus erythematosus activity.
العنوان: | Higher CD4 + CD40 + T cells (Th40 cells) associate with systemic lupus erythematosus activity. |
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المؤلفون: | Zhu L; Department of Rheumatology and Immunology, First Affiliated Hospital, Jinan University, Guangzhou, 510632, China. zhulihua20121113@163.com.; Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China. zhulihua20121113@163.com., Song G; Department of Rheumatology and Immunology, First Affiliated Hospital, Jinan University, Guangzhou, 510632, China., Chen X; Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China., Zhang Y; Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China., Cui Y; Department of Rheumatology and Immunology, First Affiliated Hospital, Jinan University, Guangzhou, 510632, China., Qiao J; Department of Rheumatology and Immunology, First Affiliated Hospital, Jinan University, Guangzhou, 510632, China., Huang X; Department of Rheumatology and Immunology, First Affiliated Hospital, Jinan University, Guangzhou, 510632, China., Li X; Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China., Liu X; Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China., Zeng X; Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China., Li Y; Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China., Wang L; Department of Oncology, First Affiliated Hospital, Jinan University, Guangzhou, 510632, China. wangliang@jnu.edu.cn., Li B; Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China. jnlibo517@163.com. |
المصدر: | Scientific reports [Sci Rep] 2023 Jul 03; Vol. 13 (1), pp. 10702. Date of Electronic Publication: 2023 Jul 03. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Serositis* , Lupus Erythematosus, Systemic* , Pneumonia*, Humans ; Interleukin-10 ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Interleukin-2 ; Interleukin-4 |
مستخلص: | The aim of this study was to investigate the characteristics of CD4 + CD40 + T cells (Th40 cells) in Chinese systemic lupus erythematosus (SLE) patients. Flow cytometry was used to identify the percentage of Th40 cells in peripheral blood from 24 SLE patients and 24 healthy individuals and the level of IL-2, IL-4, IL-6, IL-10, IFN-r, and TNF-α in serum (22 cases) from the SLE patients. Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2000) was used to assess the SLE disease active state. The percentage of Th40 cells in T cells from SLE patients (19.37 ± 17.43) (%) was significantly higher than that from healthy individuals (4.52 ± 3.16) (%) (P < 0.001). The percentage of Th40 cells was also positively associated with SLEDAI-2000 (P = 0.001) and negatively associated with complement C3 (P = 0.007). The Th40 cell percentage was different in SLE patients with different organs involved. The Th40 cell percentage in SLE patients with lupus serositis (29.29 ± 22.19) was significantly higher than that in patients without serositis (13.41 ± 10.79; P = 0.040), and the percentage in SLE patients with lupus pneumonia involvement (29.11 ± 11.88) was significantly higher than that in patients without lupus pneumonia (16.80 ± 17.99; P = 0.043). After 4 weeks treatment, the Th40 cell percentage decreased significantly (P = 0.005). However, Th40 cell expression was not related to cytokines (IL-2, IL-4, IL-6, IL-10, IFN-r, and TNF-α; P > 0.05). A significantly higher percentage of Th40 cells was found in SLE patients, and the Th40 cell percentage was associated with SLE activity. Thus, Th40 cells may be used as a predictor for SLE disease activity and severity and therapeutic efficacy. (© 2023. The Author(s).) |
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المشرفين على المادة: | 130068-27-8 (Interleukin-10) 0 (Interleukin-6) 0 (Tumor Necrosis Factor-alpha) 0 (Interleukin-2) 207137-56-2 (Interleukin-4) |
تواريخ الأحداث: | Date Created: 20230703 Date Completed: 20230705 Latest Revision: 20230706 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC10317960 |
DOI: | 10.1038/s41598-023-37749-y |
PMID: | 37400575 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2045-2322 |
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DOI: | 10.1038/s41598-023-37749-y |