دورية أكاديمية
Direct mapping of kidney function by DCE-MRI urography using a tetrazinanone organic radical contrast agent.
العنوان: | Direct mapping of kidney function by DCE-MRI urography using a tetrazinanone organic radical contrast agent. |
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المؤلفون: | Calvert ND; Department of Chemistry and Biomolecular Sciences, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada., Kirby A; Department of Biology, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada., Suchý M; Department of Chemistry and Biomolecular Sciences, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada., Pallister P; Department of Chemistry, Carleton University, 1125 Colonel By Dr., Ottawa, Ontario, K1S 5B6, Canada., Torrens AA; Department of Chemistry and Biomolecular Sciences, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada., Burger D; Kidney Research Center, Ottawa Hospital Research Institute, University of Ottawa, 501 Smyth Rd, Ottawa, Ontario, K1H 8L6, Canada., Melkus G; Dept. Medical Imaging, The Ottawa Hospital, 501 Smyth Rd, Ottawa, Ontario, K1H 8L6, Canada.; Dept. Radiology, University of Ottawa, 501 Smyth Rd, Ottawa, Ontario, K1H 8L6, Canada., Schieda N; Dept. Radiology, University of Ottawa, 501 Smyth Rd, Ottawa, Ontario, K1H 8L6, Canada., Shuhendler AJ; Department of Chemistry and Biomolecular Sciences, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada. adam.shuhendler@uottawa.ca.; Department of Biology, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada. adam.shuhendler@uottawa.ca.; University of Ottawa Heart Institute, 40 Ruskin St., Ottawa, Ontario, K1Y 4W7, Canada. adam.shuhendler@uottawa.ca. |
المصدر: | Nature communications [Nat Commun] 2023 Jul 05; Vol. 14 (1), pp. 3965. Date of Electronic Publication: 2023 Jul 05. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
مواضيع طبية MeSH: | Acute Kidney Injury*/chemically induced , Acute Kidney Injury*/diagnostic imaging , Renal Insufficiency, Chronic*/diagnostic imaging, Mice ; Animals ; Contrast Media ; Kidney/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Urography |
مستخلص: | Chronic kidney disease (CKD) and acute kidney injury (AKI) are ongoing global health burdens. Glomerular filtration rate (GFR) is the gold standard measure of kidney function, with clinical estimates providing a global assessment of kidney health without spatial information of kidney- or region-specific dysfunction. The addition of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to the anatomical imaging already performed would yield a 'one-stop-shop' for renal assessment in cases of suspected AKI and CKD. Towards urography by DCE-MRI, we evaluated a class of nitrogen-centered organic radicals known as verdazyls, which are extremely stable even in highly reducing environments. A glucose-modified verdazyl, glucoverdazyl, provided contrast limited to kidney and bladder, affording functional kidney evaluation in mouse models of unilateral ureteral obstruction (UUO) and folic acid-induced nephropathy (FAN). Imaging outcomes correlated with histology and hematology assessing kidney dysfunction, and glucoverdazyl clearance rates were found to be a reliable surrogate measure of GFR. (© 2023. The Author(s).) |
References: | N Engl J Med. 2000 Sep 14;343(11):750-8. (PMID: 10984562) Animal Model Exp Med. 2021 Nov 24;4(4):329-342. (PMID: 34977484) Chem Rev. 1999 Sep 8;99(9):2293-352. (PMID: 11749483) Magn Reson Med. 2001 Nov;46(5):917-22. (PMID: 11675643) J Magn Reson Imaging. 2009 Dec;30(6):1259-67. (PMID: 19938038) Am J Physiol Renal Physiol. 2018 Nov 1;315(5):F1252-F1260. (PMID: 30089037) Antioxid Redox Signal. 2022 Jan;36(1-3):95-121. (PMID: 34148403) Kidney Int. 2009 Jun;75(11):1145-1152. (PMID: 19340094) Chem Soc Rev. 2006 Jun;35(6):512-23. (PMID: 16729145) Biomolecules. 2019 Apr 08;9(4):. (PMID: 30965656) Methods Mol Biol. 2021;2216:429-441. (PMID: 33476015) Lancet. 1999 Jul 31;354(9176):359-64. (PMID: 10437863) Kidney Int. 2021 Nov;100(5):1001-1011. (PMID: 33984338) Metallomics. 2019 Feb 20;11(2):240-254. (PMID: 30516229) J Am Soc Nephrol. 2009 Mar;20(3):672-9. (PMID: 19244578) J Nutr. 2008 Apr;138(4):653-8. (PMID: 18356316) Chem Commun (Camb). 2002 Aug 21;(16):1688-9. (PMID: 12196951) Chem Sci. 2020 Feb 5;11(8):2045-2050. (PMID: 32180926) Nat Med. 2015 Jan;21(1):37-46. (PMID: 25419705) Chem Rev. 2019 Jan 23;119(2):957-1057. (PMID: 30350585) Can J Kidney Health Dis. 2018 Jun 12;5:2054358118778573. (PMID: 29977584) Pathology. 1987 Apr;19(2):143-9. (PMID: 2840627) Kidney Int Rep. 2021 Jan 06;6(3):685-694. (PMID: 33732983) Adv Chronic Kidney Dis. 2011 Jan;18(1):28-41. (PMID: 21224028) Am J Physiol Renal Physiol. 2012 Sep;303(5):F783-8. (PMID: 22696603) Am J Physiol Renal Physiol. 2013 Feb 15;304(4):F432-9. (PMID: 23220725) Ann Intern Med. 2020 Jul 21;173(2):110-119. (PMID: 32568573) Kidney Med. 2020 Nov 10;3(1):142-150. (PMID: 33604544) N Engl J Med. 2014 Jul 3;371(1):58-66. (PMID: 24988558) Bioconjug Chem. 2019 Sep 18;30(9):2264-2286. (PMID: 31380621) J Am Chem Soc. 2012 Sep 26;134(38):15724-7. (PMID: 22974177) AJR Am J Roentgenol. 2006 Sep;187(3):W316-9. (PMID: 16928911) Kidney Int. 2016 Dec;90(6):1377-1385. (PMID: 27665115) N Engl J Med. 2019 Jun 13;380(24):2295-2306. (PMID: 30990260) N Engl J Med. 2001 Sep 20;345(12):861-9. (PMID: 11565518) Nat Rev Dis Primers. 2017 Nov 23;3:17088. (PMID: 29168475) Acta Inform Med. 2017 Jun;25(2):99-102. (PMID: 28883673) Org Lett. 2004 Jun 10;6(12):1887-90. (PMID: 15176775) J Org Chem. 1999 Nov 26;64(24):8893-8897. (PMID: 11674795) J Nucl Med. 2014 May;55(5):786-98. (PMID: 24591488) J Am Soc Nephrol. 2001 Jun;12(6):1173-1187. (PMID: 11373340) Nephron. 2016;133(1):53-61. (PMID: 27212380) Clin J Am Soc Nephrol. 2010 Mar;5(3):484-9. (PMID: 20093350) PLoS One. 2019 Jun 28;14(6):e0218986. (PMID: 31251767) Am J Pathol. 2006 May;168(5):1413-24. (PMID: 16651609) IEEE Trans Biomed Eng. 2016 Aug;63(8):1742-50. (PMID: 26595905) Clin Kidney J. 2021 Apr 20;14(7):1719-1730. (PMID: 34221379) Nephron. 2017;136(4):287-291. (PMID: 27978513) Semin Nucl Med. 2022 Jul;52(4):453-466. (PMID: 35063168) J Vis Exp. 2018 Oct 21;(140):. (PMID: 30394397) Pediatr Nephrol. 2012 Aug;27(8):1233-47. (PMID: 21695449) PLoS One. 2021 Dec 29;16(12):e0261977. (PMID: 34965267) Nat Rev Nephrol. 2011 Jun 28;7(8):446-57. (PMID: 21712852) Cell Death Dis. 2021 Aug 14;12(8):792. (PMID: 34392303) Am J Physiol Renal Physiol. 2004 Jun;286(6):F1116-9. (PMID: 14970000) J Am Chem Soc. 2016 Sep 28;138(38):12541-51. (PMID: 27570149) JAMA Intern Med. 2020 Feb 1;180(2):223-230. (PMID: 31816007) Clin J Am Soc Nephrol. 2020 Aug 7;15(8):1203-1212. (PMID: 32393465) Front Pharmacol. 2021 Feb 24;12:620433. (PMID: 33716747) Front Pharmacol. 2019 Nov 14;10:1314. (PMID: 31803050) J Nucl Med. 2014 Apr;55(4):608-15. (PMID: 24549283) Free Radic Biol Med. 1993 Oct;15(4):415-23. (PMID: 8225023) AJR Am J Roentgenol. 2015 Mar;204(3):W273-81. (PMID: 25714312) Crit Care. 2012 Sep 24;16(5):158. (PMID: 23014799) PLoS One. 2013 Aug 19;8(8):e71519. (PMID: 23977062) Kidney Int. 2022 Jun;101(6):1251-1259. (PMID: 35227691) Front Mol Neurosci. 2018 Sep 20;11:335. (PMID: 30294259) Dalton Trans. 2018 Apr 3;47(14):4785-4789. (PMID: 29532846) Chem Sci. 2015 Aug 1;6(8):4712-4716. (PMID: 29142709) JAMA Netw Open. 2019 Sep 4;2(9):e1910704. (PMID: 31483474) PLoS One. 2021 Aug 12;16(8):e0255869. (PMID: 34383841) JAMA. 2019 Oct 1;322(13):1294-1304. (PMID: 31573641) Free Radic Biol Med. 2020 Jul;154:18-32. (PMID: 32360615) Adv Exp Med Biol. 2017;977:73-79. (PMID: 28685430) Front Pharmacol. 2021 Jun 22;12:662020. (PMID: 34239439) PLoS One. 2015 Apr 28;10(4):e0125361. (PMID: 25919356) Org Biomol Chem. 2005 Dec 7;3(23):4258-61. (PMID: 16294256) Langmuir. 2019 Dec 31;35(52):17054-17060. (PMID: 31790590) Experientia. 1985 Jan 15;41(1):72-3. (PMID: 3967741) Radiol Cardiothorac Imaging. 2019 Aug 29;1(3):e190104. (PMID: 33778513) Eur Radiol. 2007 Nov;17(11):2780-93. (PMID: 17646992) Phys Chem Chem Phys. 2018 Mar 14;20(11):7661-7675. (PMID: 29497710) |
معلومات مُعتمدة: | PJT-180355 Canada CIHR |
سلسلة جزيئية: | figshare 10.6084/m9.figshare.23538426 |
المشرفين على المادة: | 0 (Contrast Media) |
تواريخ الأحداث: | Date Created: 20230705 Date Completed: 20230707 Latest Revision: 20230718 |
رمز التحديث: | 20230718 |
مُعرف محوري في PubMed: | PMC10322853 |
DOI: | 10.1038/s41467-023-39720-x |
PMID: | 37407664 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2041-1723 |
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DOI: | 10.1038/s41467-023-39720-x |