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Direct mapping of kidney function by DCE-MRI urography using a tetrazinanone organic radical contrast agent.

التفاصيل البيبلوغرافية
العنوان: Direct mapping of kidney function by DCE-MRI urography using a tetrazinanone organic radical contrast agent.
المؤلفون: Calvert ND; Department of Chemistry and Biomolecular Sciences, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada., Kirby A; Department of Biology, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada., Suchý M; Department of Chemistry and Biomolecular Sciences, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada., Pallister P; Department of Chemistry, Carleton University, 1125 Colonel By Dr., Ottawa, Ontario, K1S 5B6, Canada., Torrens AA; Department of Chemistry and Biomolecular Sciences, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada., Burger D; Kidney Research Center, Ottawa Hospital Research Institute, University of Ottawa, 501 Smyth Rd, Ottawa, Ontario, K1H 8L6, Canada., Melkus G; Dept. Medical Imaging, The Ottawa Hospital, 501 Smyth Rd, Ottawa, Ontario, K1H 8L6, Canada.; Dept. Radiology, University of Ottawa, 501 Smyth Rd, Ottawa, Ontario, K1H 8L6, Canada., Schieda N; Dept. Radiology, University of Ottawa, 501 Smyth Rd, Ottawa, Ontario, K1H 8L6, Canada., Shuhendler AJ; Department of Chemistry and Biomolecular Sciences, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada. adam.shuhendler@uottawa.ca.; Department of Biology, University of Ottawa, 150 Louis Pasteur Pvt., Ottawa, Ontario, K1N 6N5, Canada. adam.shuhendler@uottawa.ca.; University of Ottawa Heart Institute, 40 Ruskin St., Ottawa, Ontario, K1Y 4W7, Canada. adam.shuhendler@uottawa.ca.
المصدر: Nature communications [Nat Commun] 2023 Jul 05; Vol. 14 (1), pp. 3965. Date of Electronic Publication: 2023 Jul 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Acute Kidney Injury*/chemically induced , Acute Kidney Injury*/diagnostic imaging , Renal Insufficiency, Chronic*/diagnostic imaging, Mice ; Animals ; Contrast Media ; Kidney/diagnostic imaging ; Magnetic Resonance Imaging/methods ; Urography
مستخلص: Chronic kidney disease (CKD) and acute kidney injury (AKI) are ongoing global health burdens. Glomerular filtration rate (GFR) is the gold standard measure of kidney function, with clinical estimates providing a global assessment of kidney health without spatial information of kidney- or region-specific dysfunction. The addition of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to the anatomical imaging already performed would yield a 'one-stop-shop' for renal assessment in cases of suspected AKI and CKD. Towards urography by DCE-MRI, we evaluated a class of nitrogen-centered organic radicals known as verdazyls, which are extremely stable even in highly reducing environments. A glucose-modified verdazyl, glucoverdazyl, provided contrast limited to kidney and bladder, affording functional kidney evaluation in mouse models of unilateral ureteral obstruction (UUO) and folic acid-induced nephropathy (FAN). Imaging outcomes correlated with histology and hematology assessing kidney dysfunction, and glucoverdazyl clearance rates were found to be a reliable surrogate measure of GFR.
(© 2023. The Author(s).)
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معلومات مُعتمدة: PJT-180355 Canada CIHR
سلسلة جزيئية: figshare 10.6084/m9.figshare.23538426
المشرفين على المادة: 0 (Contrast Media)
تواريخ الأحداث: Date Created: 20230705 Date Completed: 20230707 Latest Revision: 20230718
رمز التحديث: 20230718
مُعرف محوري في PubMed: PMC10322853
DOI: 10.1038/s41467-023-39720-x
PMID: 37407664
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-023-39720-x