دورية أكاديمية
أعرض في EDS

Low Ang-(1-7) and high des-Arg9 bradykinin serum levels are correlated with cardiovascular risk factors in patients with COVID-19.

التفاصيل البيبلوغرافية
العنوان: Low Ang-(1-7) and high des-Arg9 bradykinin serum levels are correlated with cardiovascular risk factors in patients with COVID-19.
المؤلفون: Rostamzadeh F; Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran., Najafipour H; Cardiovascular and Respiratory Physiology, Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran., Nakhaei S; Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran., Yazdani R; Department of Internal Medicine, School of Medicine, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran., Langari AA; Gastroenterology, and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
المصدر: Open medicine (Warsaw, Poland) [Open Med (Wars)] 2023 Jul 04; Vol. 18 (1), pp. 20230741. Date of Electronic Publication: 2023 Jul 04 (Print Publication: 2023).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: De Gruyter Open Country of Publication: Poland NLM ID: 101672167 Publication Model: eCollection Cited Medium: Print ISSN: 2391-5463 (Print) NLM ISO Abbreviation: Open Med (Wars) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Warsaw, Poland : De Gruyter Open, [2015]-
مستخلص: It is predictable that the renin-angiotensin-aldosterone and kinin-kallikrein systems are dysregulated in COVID-19 (COV) patients because SARS-CoV-2 requires ACE2 to cause an infection. This study aimed to assess the serum levels of des-arg(9)-bradykinin (DABK) and angiotensin 1-7 (ang-(1-7)) in patients with COV who had the above-mentioned cardiovascular disease risk factors. In a cross-sectional study, 69 COV patients were selected among patients referred to the main referral center for these patients, in Kerman, Iran, and 73 matched control (non-COV) individuals among individuals who participated in the KERCARD cohort study. Serum levels of DABK and ang-(1-7) were measured by ELISA in the groups of CTL (healthy), HTN, DM, OB, COV, COV + HTN, COV + DM, and COV + OB. Ang-(1-7) levels were lower in the COV + HTN group compared to the HTN group. DABK levels were higher in the COV, HTN, and OB groups and in DM + COV subjects compared to their corresponding control group. The levels of ang-(1-7) and DABK were related to HTN and OB, respectively. According to the findings, we can infer that an increase in DABK production in those with the cardiovascular disease risk factors of diabetes, obesity, and hypertension or a decrease in ang-(1-7) in those with hypertension may contribute to the adverse outcomes of SARS-CoV-2 infection.
Competing Interests: Conflict of interest: The authors declare that they have no conflict of interest.
(© 2023 the author(s), published by De Gruyter.)
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فهرسة مساهمة: Keywords: COVID-19; angiotensin-(1–7); cardiovascular risk factors; des-Arg (9)-bradykinin
تواريخ الأحداث: Date Created: 20230707 Latest Revision: 20230718
رمز التحديث: 20230718
مُعرف محوري في PubMed: PMC10320568
DOI: 10.1515/med-2023-0741
PMID: 37415613
قاعدة البيانات: MEDLINE
الوصف
تدمد:2391-5463
DOI:10.1515/med-2023-0741