دورية أكاديمية
أعرض في EDS

Oral Cavity Fluid as an Alternative Postmortem Matrix: Comparison to Simultaneously Collected Blood and Urine Specimens.

التفاصيل البيبلوغرافية
العنوان: Oral Cavity Fluid as an Alternative Postmortem Matrix: Comparison to Simultaneously Collected Blood and Urine Specimens.
المؤلفون: Cox J; From the Department of Forensic and Investigative Science, West Virginia University, Morgantown, WV., Morris K; From the Department of Forensic and Investigative Science, West Virginia University, Morgantown, WV., Miller AC; SteelFusion Clinical Toxicology Laboratory, LLC, Monessen, PA., Champion JL; SteelFusion Clinical Toxicology Laboratory, LLC, Monessen, PA., Reisinger AJ; SteelFusion Clinical Toxicology Laboratory, LLC, Monessen, PA., Pandey M; Forensic Pathologist, The Forensic Pathologists LLC, Holland, OH., Kraner JC; Retired Chief Toxicologist, Las Cruces, NM., Arroyo-Mora LE; From the Department of Forensic and Investigative Science, West Virginia University, Morgantown, WV.
المصدر: The American journal of forensic medicine and pathology [Am J Forensic Med Pathol] 2023 Dec 01; Vol. 44 (4), pp. 258-266. Date of Electronic Publication: 2023 Jul 04.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 8108948 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-404X (Electronic) Linking ISSN: 01957910 NLM ISO Abbreviation: Am J Forensic Med Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2002- > : Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: New York : Masson Publishing USA.
مواضيع طبية MeSH: Morphine* , Mouth*, Humans ; Autopsy ; Postmortem Changes ; Fentanyl ; Forensic Toxicology/methods
مستخلص: Abstract: In postmortem toxicology analysis, a variety of specimens consisting of fluids and tissues are often collected, each with an intrinsic value. Oral cavity fluid (OCF) is emerging as an alternative matrix in forensic toxicology for contributing to a diagnosis in postmortem cases; especially when blood is limited or not available. The aim of this study was to assess the analytical results obtained from OCF and compare them with blood, urine, and other traditional matrices collected from the same postmortem subjects. Of the 62 decedents studied (including 1 stillborn, 1 charred, and 3 decomposed subjects), 56 had quantifiable drugs and metabolites data in the OCF, blood, and urine. Notable findings were benzoylecgonine (24 cases), ethyl sulfate (23 cases), acetaminophen (21 cases), morphine (21 cases), naloxone (21 cases), gabapentin (20 cases), fentanyl (17 cases), and 6-acetylmorphine (15 cases), which were detected more frequently in OCF than in blood (heart, femoral, or body cavity) or urine. This study suggests that OCF is a suitable matrix for detecting and quantifying analytes in postmortem subjects compared with traditional matrices, particularly when other matrices are limited or difficult to collect because of body condition or putrefaction.
Competing Interests: The authors report no conflict of interest.
(Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
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المشرفين على المادة: 76I7G6D29C (Morphine)
UF599785JZ (Fentanyl)
تواريخ الأحداث: Date Created: 20230707 Date Completed: 20231201 Latest Revision: 20240624
رمز التحديث: 20240624
DOI: 10.1097/PAF.0000000000000854
PMID: 37417473
قاعدة البيانات: MEDLINE
الوصف
تدمد:1533-404X
DOI:10.1097/PAF.0000000000000854