دورية أكاديمية
Iron metabolism: An emerging therapeutic target underlying the anti-Alzheimer's disease effect of ginseng.
| العنوان: | Iron metabolism: An emerging therapeutic target underlying the anti-Alzheimer's disease effect of ginseng. |
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| المؤلفون: | Li N; Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, China., Duan YH; Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, China., Chen L; Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun, China., Zhang K; Department of Medical Research Center, The Second Hospital of Jilin University, Changchun, China. Electronic address: zk303@jlu.edu.cn. |
| المصدر: | Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) [J Trace Elem Med Biol] 2023 Sep; Vol. 79, pp. 127252. Date of Electronic Publication: 2023 Jun 24. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Gustav Fisher Country of Publication: Germany NLM ID: 9508274 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3252 (Electronic) Linking ISSN: 0946672X NLM ISO Abbreviation: J Trace Elem Med Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Stuttgart : Gustav Fisher Original Publication: Stuttgart ; New York : Gustav Fischer, c1995- |
| مواضيع طبية MeSH: | Panax*/metabolism , Alzheimer Disease*/drug therapy , Alzheimer Disease*/metabolism , Ferroptosis*, Humans ; Iron/metabolism ; Brain/metabolism |
| مستخلص: | Finding neuroprotective drugs with fewer side effects and more efficacy has become a major problem as the global prevalence of Alzheimer's disease (AD) rises. Natural drugs have risen to prominence as potential medication candidates. Ginseng has a long history of use in China, and it has a wide range of pharmacological actions that can help with neurological issues. Iron loaded in the brain has been linked to AD pathogenesis. We reviewed the regulation of iron metabolism and its studies in AD and explored how ginseng might regulate iron metabolism and prevent or treat AD. Researchers utilized network pharmacology analysis to identify key factive components of ginseng that protect against AD by regulating ferroptosis. Ginseng and its active ingredients may benefit AD by regulating iron metabolism and targeting ferroptosis genes to inhibit the ferroptosis process. The results present new ideas for ginseng pharmacological studies and initiatives for further research into AD-related drugs. To provide comprehensive information on the neuroprotective use of ginseng to modulate iron metabolism, reveal its potential to treat AD, and provide insights for future research opportunities. Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest pertaining to this manuscript. (Copyright © 2023 Elsevier GmbH. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Alzheimer's disease; Ferroptosis; Ginseng; Network pharmacology |
| المشرفين على المادة: | E1UOL152H7 (Iron) |
| تواريخ الأحداث: | Date Created: 20230707 Date Completed: 20230807 Latest Revision: 20230807 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jtemb.2023.127252 |
| PMID: | 37418790 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1878-3252 |
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| DOI: | 10.1016/j.jtemb.2023.127252 |