دورية أكاديمية
Effect of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and benzo[a]pyrene exposure on the development of metabolic syndrome in mice.
| العنوان: | Effect of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and benzo[a]pyrene exposure on the development of metabolic syndrome in mice. |
|---|---|
| المؤلفون: | Jang HJ; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea., Boo HJ; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea., Min HY; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea., Kang YP; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea., Kwon SW; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea., Lee HY; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. Electronic address: hylee135@snu.ac.kr. |
| المصدر: | Life sciences [Life Sci] 2023 Sep 15; Vol. 329, pp. 121925. Date of Electronic Publication: 2023 Jul 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0375521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0631 (Electronic) Linking ISSN: 00243205 NLM ISO Abbreviation: Life Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2008->: Amsterdam : Elsevier Original Publication: Oxford; Elmsford, N. Y. [etc.] Pergamon Press. |
| مواضيع طبية MeSH: | Metabolic Syndrome*/chemically induced , Nitrosamines*/toxicity , Nitrosamines*/metabolism , Lung Neoplasms*/chemically induced, Mice ; Animals ; Humans ; Benzo(a)pyrene/toxicity ; 1-Butanol/adverse effects ; Blood Glucose ; Mice, Inbred C57BL ; Carcinogens/toxicity ; Carcinogens/metabolism |
| مستخلص: | Aim: The prevalence of metabolic syndrome (MetS), a cluster of serious medical conditions that raise the risk of lung cancer, has increased worldwide. Tobacco smoking (TS) potentially increases the risk of developing MetS. Despite the potential association of MetS with lung cancer, preclinical models that mimic human diseases, including TS-induced MetS, are limited. Here we evaluated the impact of exposure to tobacco smoke condensate (TSC) and two representative tobacco carcinogens, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNK) and benzo[a]pyrene (BaP), on MetS development in mice. Materials and Methods: FVB/N or C57BL/6 mice were exposed to vehicle, TSC, or NNK and BaP (NB) twice weekly for 5 months. The serum levels of total cholesterol (TCHO), triglycerides, high-density lipoprotein (HDL), blood glucose, and metabolites, along with glucose tolerance and body weight, were measured. Key Findings: Compared with those of vehicle-treated mice, mice with TSC or NB exposure displayed major phenotypes associated with MetS, including increased serum levels of TCHO, triglycerides, and fasting and basal blood glucose and decreased glucose tolerance, and serum levels of HDL. These MetS-associated changes were found in both FVB/N and C57BL/6 mice that were susceptible or resistant to carcinogen-induced tumorigenesis, respectively, indicating that tumor formation is not involved in the TSC- or NB-mediated MetS. Moreover, oleic acid and palmitoleic acid, which are known to be associated with MetS, were significantly upregulated in the serum of TSC- or NB-treated mice compared with those in vehicle-treated mice. Significance: Both TSC and NB caused detrimental health problems, leading to the development of MetS in experimental mice. Competing Interests: Declaration of competing interest The authors declare that there are no conflicts of interests. (Copyright © 2023 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Animal model; Fatty acid; Lung cancer; Metabolic syndrome; Tobacco smoking |
| المشرفين على المادة: | EN7PIX794W (4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol) 3417WMA06D (Benzo(a)pyrene) 8PJ61P6TS3 (1-Butanol) 0 (Blood Glucose) 0 (Nitrosamines) 0 (Carcinogens) |
| تواريخ الأحداث: | Date Created: 20230709 Date Completed: 20230814 Latest Revision: 20230814 |
| رمز التحديث: | 20230814 |
| DOI: | 10.1016/j.lfs.2023.121925 |
| PMID: | 37423377 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0631 |
|---|---|
| DOI: | 10.1016/j.lfs.2023.121925 |