دورية أكاديمية
Spatial Multiomics Analysis in Psychiatric Disorders.
| العنوان: | Spatial Multiomics Analysis in Psychiatric Disorders. |
|---|---|
| المؤلفون: | Mao Q; Department of Psychosomatic Medicine, People's Hospital of Deyang City, Deyang, Sichuan 618000, China., Huang S; Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Luo X; Department of Neurosurgery, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350001, China., Liu P; Department of Psychosomatic Medicine, People's Hospital of Deyang City, Deyang, Sichuan 618000, China., Wang X; Department of Neurology, Jiading Branch of Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Wang K; Department of Family and Community Health, School of Nursing, Health Sciences Center, West Virginia University, Morgantown, WV 26506, USA., Zhang Y; Tianjin Mental Health Center, Tianjin 300222, China., Chen B; Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University; Department of Cardiovascular Medicine, Fujian Provincial Hospital, Fuzhou, Fujian 350001, China., Luo X; Beijing Huilongguan Hospital, Peking University Huilongguan Clinical School of Medicine, Beijing 100096, China.; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA. |
| المصدر: | EC psychology and psychiatry [EC Psychol Psychiatr] 2023 Jun 01; Vol. 12 (6), pp. 1-5. Date of Electronic Publication: 2023 Jun 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: ECronicon Country of Publication: England NLM ID: 101735486 Publication Model: Print-Electronic Cited Medium: Internet NLM ISO Abbreviation: EC Psychol Psychiatr Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [London, United Kingdom] : ECronicon |
| مستخلص: | The aim of this study is to provide a comprehensive overview of spatial multiomics analysis, including its definition, processes, applications, significance and relevant research in psychiatric disorders. To achieve this, a literature search was conducted, focusing on three major spatial omics techniques and their application to three common psychiatric disorders: Alzheimer's disease (AD), schizophrenia, and autism spectrum disorders. Spatial genomics analysis has revealed specific genes associated with neuropsychiatric disorders in certain brain regions. Spatial transcriptomics analysis has identified genes related to AD in areas such as the hippocampus, olfactory bulb, and middle temporal gyrus. It has also provided insight into the response to AD in mouse models. Spatial proteogenomics has identified autism spectrum disorder (ASD)-risk genes in specific cell types, while schizophrenia risk loci have been linked to transcriptional signatures in the human hippocampus. In summary, spatial multiomics analysis offers a powerful approach to understand AD pathology and other psychiatric diseases, integrating multiple data modalities to identify risk genes for these disorders. It is valuable for studying psychiatric disorders with high or low cellular heterogeneity and provides new insights into the brain nucleome to predict disease progression and aid diagnosis and treatment. |
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| معلومات مُعتمدة: | R21 AA023237 United States AA NIAAA NIH HHS |
| فهرسة مساهمة: | Keywords: Alzheimer’s disease; Autism spectrum disorder; Schizophrenia; Spatial genomics; Spatial proteogenomics; Spatial transcriptomics |
| تواريخ الأحداث: | Date Created: 20230710 Latest Revision: 20230718 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10328214 |
| PMID: | 37424930 |
| قاعدة البيانات: | MEDLINE |
| الوصف غير متاح. |