التفاصيل البيبلوغرافية
| العنوان: |
Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection. |
| المؤلفون: |
Spiga L, Fansler RT, Perera YR, Shealy NG, Munneke MJ, Torres TP, David HE, Lemoff A, Ran X, Richardson KL, Pudlo N, Martens EC, Yang ZJ, Skaar EP, Byndloss MX, Chazin WJ, Zhu W |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2023 Jun 26. Date of Electronic Publication: 2023 Jun 26. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
During intestinal inflammation, host nutritional immunity starves microbes of essential micronutrients such as iron. Pathogens scavenge iron using siderophores, which is counteracted by the host using lipocalin-2, a protein that sequesters iron-laden siderophores, including enterobactin. Although the host and pathogens compete for iron in the presence of gut commensal bacteria, the roles of commensals in nutritional immunity involving iron remain unexplored. Here, we report that the gut commensal Bacteroides thetaiotaomicron acquires iron in the inflamed gut by utilizing siderophores produced by other bacteria including Salmonella, via a secreted siderophore-binding lipoprotein termed XusB. Notably, XusB-bound siderophores are less accessible to host sequestration by lipocalin-2 but can be "re-acquired" by Salmonella , allowing the pathogen to evade nutritional immunity. As the host and pathogen have been the focus of studies of nutritional immunity, this work adds commensal iron metabolism as a previously unrecognized mechanism modulating the interactions between pathogen and host nutritional immunity. |
| التعليقات: |
Update in: Cell Host Microbe. 2023 Sep 25;:. (PMID: 37776864) |
| تواريخ الأحداث: |
Date Created: 20230710 Latest Revision: 20240313 |
| رمز التحديث: |
20240313 |
| مُعرف محوري في PubMed: |
PMC10326984 |
| DOI: |
10.1101/2023.06.25.546471 |
| PMID: |
37425782 |
| قاعدة البيانات: |
MEDLINE |
