Decoupled evolution of the Sex Peptide gene family and Sex Peptide Receptor in Drosophilidae .
| العنوان: | Decoupled evolution of the Sex Peptide gene family and Sex Peptide Receptor in Drosophilidae . |
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| المؤلفون: | Hopkins BR; Department of Evolution and Ecology, University of California - Davis, CA, USA., Angus-Henry A; Department of Evolution and Ecology, University of California - Davis, CA, USA., Kim BY; Department of Biology, Stanford University, CA, USA., Carlisle JA; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA., Thompson A; Department of Evolution and Ecology, University of California - Davis, CA, USA., Kopp A; Department of Evolution and Ecology, University of California - Davis, CA, USA. |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 16. Date of Electronic Publication: 2023 Nov 16. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | Across internally fertilising species, males transfer ejaculate proteins that trigger wide-ranging changes in female behaviour and physiology. Much theory has been developed to explore the drivers of ejaculate protein evolution. The accelerating availability of high-quality genomes now allows us to test how these proteins are evolving at fine taxonomic scales. Here, we use genomes from 264 species to chart the evolutionary history of Sex Peptide (SP), a potent regulator of female post-mating responses in Drosophila melanogaster . We infer that SP first evolved in the Drosophilinae subfamily and has followed markedly different evolutionary trajectories in different lineages. Outside of the Sophophora-Lordiphosa, SP exists largely as a single-copy gene with independent losses in several lineages. Within the Sophophora-Lordiphosa , the SP gene family has repeatedly and independently expanded. Up to seven copies, collectively displaying extensive sequence variation, are present in some species. Despite these changes, SP expression remains restricted to the male reproductive tract. Alongside, we document considerable interspecific variation in the presence and morphology of seminal microcarriers that, despite the critical role SP plays in microcarrier assembly in D. melanogaster , appear to be independent of changes in the presence/absence or sequence of SP. We end by providing evidence that SP's evolution is decoupled from that of its receptor, SPR, in which we detect no evidence of correlated diversifying selection. Collectively, our work describes the divergent evolutionary trajectories that a novel gene has taken following its origin and finds a surprisingly weak coevolutionary signal between a supposedly sexually antagonistic protein and its receptor. |
| التعليقات: | Update in: Proc Natl Acad Sci U S A. 2024 Jan 16;121(3):e2312380120. (PMID: 38215185) |
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| معلومات مُعتمدة: | F32 GM135998 United States GM NIGMS NIH HHS; R35 GM122592 United States GM NIGMS NIH HHS; R37 HD038921 United States HD NICHD NIH HHS |
| تواريخ الأحداث: | Date Created: 20230710 Latest Revision: 20240210 |
| رمز التحديث: | 20240210 |
| مُعرف محوري في PubMed: | PMC10327216 |
| DOI: | 10.1101/2023.06.29.547128 |
| PMID: | 37425821 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2023.06.29.547128 |
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