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Neuronal wiring diagram of an adult brain.

التفاصيل البيبلوغرافية
العنوان: Neuronal wiring diagram of an adult brain.
المؤلفون: Dorkenwald S; Princeton Neuroscience Institute, Princeton University, Princeton, USA.; Computer Science Department, Princeton University, Princeton, USA., Matsliah A; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Sterling AR; Princeton Neuroscience Institute, Princeton University, Princeton, USA.; Eyewire, Boston, USA., Schlegel P; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK., Yu SC; Princeton Neuroscience Institute, Princeton University, Princeton, USA., McKellar CE; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Lin A; Princeton Neuroscience Institute, Princeton University, Princeton, USA.; Center for the Physics of Biological Function, Princeton University, Princeton, USA., Costa M; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK., Eichler K; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK., Yin Y; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK., Silversmith W; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Schneider-Mizell C; Allen Institute for Brain Science, Seattle, USA., Jordan CS; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Brittain D; Allen Institute for Brain Science, Seattle, USA., Halageri A; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Kuehner K; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Ogedengbe O; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Morey R; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Gager J; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Kruk K; Eyewire, Boston, USA., Perlman E; Yikes LLC, Baltimore, USA., Yang R; Princeton Neuroscience Institute, Princeton University, Princeton, USA.; Computer Science Department, Princeton University, Princeton, USA., Deutsch D; Princeton Neuroscience Institute, Princeton University, Princeton, USA.; Department of Neurobiology, University of Haifa, Haifa, Israel., Bland D; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Sorek M; Princeton Neuroscience Institute, Princeton University, Princeton, USA.; Eyewire, Boston, USA., Lu R; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Macrina T; Princeton Neuroscience Institute, Princeton University, Princeton, USA.; Computer Science Department, Princeton University, Princeton, USA., Lee K; Princeton Neuroscience Institute, Princeton University, Princeton, USA.; Brain & Cognitive Sciences Department, Massachusetts Institute of Technology, Cambridge, USA., Bae JA; Princeton Neuroscience Institute, Princeton University, Princeton, USA.; Electrical and Computer Engineering Department, Princeton University, Princeton, USA., Mu S; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Nehoran B; Princeton Neuroscience Institute, Princeton University, Princeton, USA.; Computer Science Department, Princeton University, Princeton, USA., Mitchell E; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Popovych S; Princeton Neuroscience Institute, Princeton University, Princeton, USA.; Computer Science Department, Princeton University, Princeton, USA., Wu J; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Jia Z; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Castro M; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Kemnitz N; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Ih D; Princeton Neuroscience Institute, Princeton University, Princeton, USA., Bates AS; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK.; Harvard Medical School, Boston, USA.; Centre for Neural Circuits and Behaviour, The University of Oxford, Oxford, UK., Eckstein N; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, USA., Funke J; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, USA., Collman F; Allen Institute for Brain Science, Seattle, USA., Bock DD; Department of Neurological Sciences, Larner College of Medicine, University of Vermont, Burlington, USA., Jefferis GSXE; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.; Drosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, UK., Seung HS; Princeton Neuroscience Institute, Princeton University, Princeton, USA.; Computer Science Department, Princeton University, Princeton, USA., Murthy M; Princeton Neuroscience Institute, Princeton University, Princeton, USA.
مؤلفون مشاركون: FlyWire Consortium
المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 11. Date of Electronic Publication: 2023 Jul 11.
نوع المنشور: Preprint
اللغة: English
بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE
مستخلص: Connections between neurons can be mapped by acquiring and analyzing electron microscopic (EM) brain images. In recent years, this approach has been applied to chunks of brains to reconstruct local connectivity maps that are highly informative, yet inadequate for understanding brain function more globally. Here, we present the first neuronal wiring diagram of a whole adult brain, containing 5×10 7 chemical synapses between ~130,000 neurons reconstructed from a female Drosophila melanogaster . The resource also incorporates annotations of cell classes and types, nerves, hemilineages, and predictions of neurotransmitter identities. Data products are available by download, programmatic access, and interactive browsing and made interoperable with other fly data resources. We show how to derive a projectome, a map of projections between regions, from the connectome. We demonstrate the tracing of synaptic pathways and the analysis of information flow from inputs (sensory and ascending neurons) to outputs (motor, endocrine, and descending neurons), across both hemispheres, and between the central brain and the optic lobes. Tracing from a subset of photoreceptors all the way to descending motor pathways illustrates how structure can uncover putative circuit mechanisms underlying sensorimotor behaviors. The technologies and open ecosystem of the FlyWire Consortium set the stage for future large-scale connectome projects in other species.
Competing Interests: Competing interests T. Macrina, K. Lee, S. Popovych, D. Ih, N. Kemnitz, and H. S. Seung declare financial interests in Zetta AI.
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معلومات مُعتمدة: R35 NS111580 United States NS NINDS NIH HHS; RF1 NS121911 United States NS NINDS NIH HHS; United Kingdom WT_ Wellcome Trust; U24 NS126935 United States NS NINDS NIH HHS; RF1 MH129268 United States MH NIMH NIH HHS; RF1 MH120679 United States MH NIMH NIH HHS; RF1 MH117815 United States MH NIMH NIH HHS
تواريخ الأحداث: Date Created: 20230710 Latest Revision: 20240419
رمز التحديث: 20240419
مُعرف محوري في PubMed: PMC10327113
DOI: 10.1101/2023.06.27.546656
PMID: 37425937
قاعدة البيانات: MEDLINE
الوصف
DOI:10.1101/2023.06.27.546656