دورية أكاديمية
أعرض في EDS

Detection of variable genotypes in common human papillomavirus-associated invasive penile squamous cell carcinomas: a study of 177 human papillomavirus-positive cases.

التفاصيل البيبلوغرافية
العنوان: Detection of variable genotypes in common human papillomavirus-associated invasive penile squamous cell carcinomas: a study of 177 human papillomavirus-positive cases.
المؤلفون: Sanchez DF; Instituto de Patología e Investigación, Asunción 1228, Paraguay; Translational Oncogenomics Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester Cancer Research Centre, Manchester M20 4GJ, UK., Fernández-Nestosa MJ; Universidad Nacional de Asunción, San Lorenzo 2111, Paraguay., Alemany L; Institut Català D'Oncologia, Barcelona 08908, Spain., Cañete-Portillo S; University of Alabama, Birmingham, AL 35233, USA., Lloveras B; Hospital Del Mar, Barcelona 08003, Spain., Clavero O; Institut Català D'Oncologia, Barcelona 08908, Spain., Rodríguez I; Instituto de Patología e Investigación, Asunción 1228, Paraguay; Universidad Nacional de Asunción, San Lorenzo 2111, Paraguay., Quint W; DDL Diagnostic Laboratory, Rijswijk 2288, Netherlands., Muñoz N; National Cancer Institute of Colombia, Bogotá 111511-110411001, Colombia., de Sanjosé S; Barcelona Institute for Global Health (ISGlobal), Barcelona 08036, Spain., Bosch FX; Institut Català D'Oncologia, Barcelona 08908, Spain., Cubilla AL; Instituto de Patología e Investigación, Asunción 1228, Paraguay; Universidad Nacional de Asunción, San Lorenzo 2111, Paraguay. Electronic address: antoniocubillaramos@gmail.com.
مؤلفون مشاركون: HPV VVAP Study Group
المصدر: Human pathology [Hum Pathol] 2023 Sep; Vol. 139, pp. 65-72. Date of Electronic Publication: 2023 Jul 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: W B Saunders Country of Publication: United States NLM ID: 9421547 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-8392 (Electronic) Linking ISSN: 00468177 NLM ISO Abbreviation: Hum Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: Philadelphia, PA : W B Saunders
Original Publication: Philadelphia, W B. Saunders Co.
مواضيع طبية MeSH: Papillomavirus Infections* , Carcinoma, Squamous Cell*/genetics , Carcinoma, Squamous Cell*/pathology , Carcinoma, Verrucous* , Penile Neoplasms*/genetics , Penile Neoplasms*/pathology , Papilloma*, Male ; Humans ; Human Papillomavirus Viruses ; Papillomaviridae/genetics ; Human papillomavirus 16/genetics ; Genotype
مستخلص: Human papillomavirus (HPV) is detected in 30-50% of invasive penile carcinomas, and it is frequently associated with basaloid and warty morphological features. Based on this heterogeneity and different clinical behaviors, we hypothesized a variation in their HPV genotypic composition. To test this, we evaluated 177 HPV-positive cases: basaloid (114), warty-basaloid (28), and warty (condylomatous) (35) invasive carcinomas. HPV DNA detection and genotyping was performed using the SPF-10/DEIA/LiPA 25 system. Nineteen HPV genotypes were detected. High-risk HPVs predominated (96%), and low-risk HPVs were rarely present. Most common genotype was HPV16 followed by HPVs 33 and 35. According to the genotypes identified, 93% of the cases would be covered with current vaccination programs. There was a significant variation in the distribution of HPV16 and non-HPV16 genotypes according to histological subtype. HPV16 was significantly frequent in basaloid (87%) and was less frequent in warty carcinomas (61%). This molecular difference, along with their distinctive macro-microscopic and prognostic features, makes basaloid and warty carcinomas unique. The gradual decreasing frequency of HPV16 demonstrated in basaloid, warty-basaloid, and warty carcinomas suggest that the basaloid cell, present in those types in decreasing proportions, may be responsible for the differences.
(Copyright © 2023 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Basaloid carcinoma; Human papillomavirus; Penile squamous cell carcinoma; Warty carcinoma; Warty-basaloid carcinoma
تواريخ الأحداث: Date Created: 20230710 Date Completed: 20230904 Latest Revision: 20230905
رمز التحديث: 20231215
DOI: 10.1016/j.humpath.2023.07.001
PMID: 37429448
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-8392
DOI:10.1016/j.humpath.2023.07.001