دورية أكاديمية
Medulla Tetrapanacis water extract alleviates inflammation and infection by regulating macrophage polarization through MAPK signaling pathway.
| العنوان: | Medulla Tetrapanacis water extract alleviates inflammation and infection by regulating macrophage polarization through MAPK signaling pathway. |
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| المؤلفون: | Kwok CT; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China., Chow FW; Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hong Kong, China.; Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, China., Cheung KY; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.; Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hong Kong, China., Zhang XY; Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China., Mok DK; Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hong Kong, China.; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong, China.; State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen, China., Kwan YW; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China., Chan GH; College of Professional and Continuing Education, The Hong Kong Polytechnic University, Hong Kong, China., Leung GP; Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China., Cheung KW; Department of Obstetrics and Gynaecology, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China., Lee SM; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, China., Wang N; Anhui Province Key Laboratory of Chinese Medicinal Formula, Anhui University of Chinese Medicine, Hefei, China., Li JJ; Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China., Seto SW; Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University, Hong Kong, China. saiwang.seto@polyu.edu.hk.; Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong, China. saiwang.seto@polyu.edu.hk.; NICM Health Research Institute, Western Sydney University, Penrith, NSW, 2751, Australia. saiwang.seto@polyu.edu.hk. |
| المصدر: | Inflammopharmacology [Inflammopharmacology] 2024 Feb; Vol. 32 (1), pp. 393-404. Date of Electronic Publication: 2023 Jul 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Basel ; Boston : Birkhäuser Original Publication: Dordrecht, The Netherlands ; Norwell, MA, USA : Kluwer Academic Publishers, c1991- |
| مواضيع طبية MeSH: | Lactation* , Lipopolysaccharides*/pharmacology, Female ; Humans ; Staphylococcus aureus ; Signal Transduction ; Inflammation/drug therapy ; Macrophages ; Anti-Inflammatory Agents/pharmacology |
| مستخلص: | Medulla Tetrapanacis (MT) is a commonly used herb to promote lactation and manage mastitis in lactating mothers. However, its anti-inflammatory and anti-bacterial effects are currently unknown. We hypothesized that MT water extract possesses anti-inflammatory and anti-bacterial effects by modulating macrophage polarization to reduce the release of inflammatory mediators and phagocytosis via inactivation of MAPKs pathways. The chemical composition of the MT water extract was analyzed by UPLC-Orbitrap-mass spectrometry. The anti-inflammatory and anti-bacterial properties of the MT water extract were examined using LPS-stimulated inflammation and Staphylococcus aureus infection model in RAW 264.7 cells, respectively. The underlying mechanism of action of the MT water extract was also investigated. We identified eight compounds by UPLC-Orbitrap-mass spectrometry that are abundant within the MT water extract. MT water extract significantly suppressed LPS-induced nitric oxide, TNF-α and IL-6 secretion in RAW 264.7 cells which was accompanied by the promotion of macrophage polarization from pro-inflammatory towards anti-inflammatory phenotypes. MT water extract significantly suppressed the LPS-induced MAPK activation. Finally, MT water extract decreased the phagocytic capacity of the RAW 264.7 cells against S. aureus infection. MT water extract could suppress LPS-induced inflammation by promoting macrophages towards an anti-inflammatory phenotype. In addition, MT also inhibited the growth of S. aureus. (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.) |
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| معلومات مُعتمدة: | General Research Fund (Project No.: P0036597) Hong Kong Polytechnic University; P0038407 Hong Kong Polytechnic University; Project No.: P0041138 Research Centre for Chinese Medicine Innovation, The Hong Kong Polytechnic University; College of Professional The Hong Kong Polytechnic University College of Professional and Continuing Education; Continuing Education Research Fund (Ref. No. SEHS-2021-233(E)) The Hong Kong Polytechnic University College of Professional and Continuing Education |
| فهرسة مساهمة: | Keywords: Medulla Tetrapanacis; Anti-bacterial; Inflammation; MAPK signaling pathway; Macrophage polarization; Mastitis |
| المشرفين على المادة: | 0 (Lipopolysaccharides) 0 (Anti-Inflammatory Agents) |
| تواريخ الأحداث: | Date Created: 20230710 Date Completed: 20240304 Latest Revision: 20240304 |
| رمز التحديث: | 20240304 |
| DOI: | 10.1007/s10787-023-01266-1 |
| PMID: | 37429999 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1568-5608 |
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| DOI: | 10.1007/s10787-023-01266-1 |