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Short-term effects of an elimination diet and healthy diet in children with attention-deficit/hyperactivity disorder: a randomized-controlled trial.

التفاصيل البيبلوغرافية
العنوان: Short-term effects of an elimination diet and healthy diet in children with attention-deficit/hyperactivity disorder: a randomized-controlled trial.
المؤلفون: Huberts-Bosch A; Karakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands. a.bosch@karakter.com., Bierens M; Karakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands., Ly V; Institute of Psychology, Leiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands., van der Velde J; Karakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands., de Boer H; Accare, Child and Adolescent Psychiatry, Groningen, The Netherlands., van Beek G; Karakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands., Appelman D; Triversum-GGZ-NHN, Child and Adolescent Psychiatry, Alkmaar, The Netherlands., Visser S; Velp, The Netherlands., Bos LHP; Karakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands., Reijmers L; Karakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands., van der Meer J; Levvel, Center for Child and Adolescent Psychiatry, Amsterdam, The Netherlands., Kamphuis N; Karakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands., Draaisma JMT; Department of Pediatrics, Radboud Institute for Health Sciences, Radboud University Medical Center Amalia Children's Hospital, Nijmegen, The Netherlands., Donders R; Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands., van de Loo-Neus GHH; Karakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands., Hoekstra PJ; Department of Child and Adolescent Psychiatry and Accare Child Study Center, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Bottelier M; Accare, Child and Adolescent Psychiatry, Groningen, The Netherlands., Arias-Vasquez A; Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands., Klip H; Karakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands., Buitelaar JK; Karakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands.; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands., van den Berg SW; National Institute for Public Health and the Environment (RIVM), Bilthoven, Utrecht, The Netherlands., Rommelse NN; Karakter, Child and Adolescent Psychiatry, Reinier Postlaan 12, 6525 GC, Nijmegen, The Netherlands.; Department of Psychiatry, Radboud University Medical Center, Nijmegen, The Netherlands.
المصدر: European child & adolescent psychiatry [Eur Child Adolesc Psychiatry] 2024 May; Vol. 33 (5), pp. 1503-1516. Date of Electronic Publication: 2023 Jul 11.
نوع المنشور: Journal Article; Randomized Controlled Trial
اللغة: English
بيانات الدورية: Publisher: Country of Publication: Germany NLM ID: 9212296 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-165X (Electronic) Linking ISSN: 10188827 NLM ISO Abbreviation: Eur Child Adolesc Psychiatry Subsets: MEDLINE
أسماء مطبوعة: Publication: 2010- : Heidelberg : Springer Medizin
Original Publication: Toronto ; Lewiston, NY : Hogrefe & Huber, [1992-
مواضيع طبية MeSH: Attention Deficit Disorder with Hyperactivity*/diet therapy , Attention Deficit Disorder with Hyperactivity*/therapy , Diet, Healthy*, Humans ; Male ; Child ; Female ; Child, Preschool ; Treatment Outcome ; Netherlands ; Emotional Regulation ; Elimination Diets
مستخلص: An Elimination Diet (ED) may be effective in reducing symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD), but has never been compared to an active control condition [i.e., Healthy Diet (HD)]. In a two-armed RCT, a total of N = 165 children (5-12 years) with ADHD were randomized by means of minimization (1:1) to either an ED (N = 84) or HD (N = 81) within two Dutch child and adolescent psychiatry centers. The design included a non-randomized comparator arm including N = 58 children being treated with Care as Usual (CAU). Treatment allocation was unblinded. The primary outcome was a 5-point ordinal measure of respondership based on a combination of parent and teacher ratings on ADHD and emotion regulation, determined after 5 weeks of treatment. Ordinal regression analyses were done on an intention-to-treat basis. Fewer ED (35%) than HD (51%) participants showed a partial to full response, despite overall good-to-excellent treatment adherence (> 88%) and comparable high parental prior believes. A younger age and higher problem severity predicted a better respondership. CAU-preferring participants responded more often favorably (56%) compared to ED-but not HD-participants. Small-to-medium improvements in physical health (blood pressure, heart rate, and somatic complaints) were found in response to ED/HD versus decrements in response to CAU (74% received psychostimulants). The lack of superiority of the ED versus HD suggests that for the majority of children, dietary treatment response is not rooted in food-allergies/-sensitivities. The comparable results for treatment with HD and CAU are remarkable given that CAU participants were probably 'easier to treat' than HD (and ED) participants with proportionally fewer with a (suboptimal/non-response to) prior treatment with medication (4% versus 20%). Further assessment of long-term effects is needed to evaluate the potential place of dietary treatment within clinical guidelines. The trial is closed and registered in the Dutch trial registry, number NL5324 ( https://www.onderzoekmetmensen.nl/en/trial/25997 ).
(© 2023. The Author(s).)
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معلومات مُعتمدة: Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; Eat2beNICE Horizon 2020 Framework Programme; 837002506 Netherlands ZONMW_ ZonMw; 837002506 Netherlands ZONMW_ ZonMw; 837002506 Netherlands ZONMW_ ZonMw; 837002506 Netherlands ZONMW_ ZonMw; 837002506 Netherlands ZONMW_ ZonMw; 837002506 Netherlands ZONMW_ ZonMw; 837002506 Netherlands ZONMW_ ZonMw; 837002506 Netherlands ZONMW_ ZonMw; 837002506 Netherlands ZONMW_ ZonMw; 837002506 Netherlands ZONMW_ ZonMw; 837002506 Netherlands ZONMW_ ZonMw; 837002506 Netherlands ZONMW_ ZonMw; 837002506 Netherlands ZONMW_ ZonMw; 837002506 Netherlands ZONMW_ ZonMw; 837002506 Netherlands ZONMW_ ZonMw
فهرسة مساهمة: Keywords: ADHD; Child psychiatry; Dietary treatment; Emotion regulation
تواريخ الأحداث: Date Created: 20230710 Date Completed: 20240516 Latest Revision: 20240519
رمز التحديث: 20240519
مُعرف محوري في PubMed: PMC11098970
DOI: 10.1007/s00787-023-02256-y
PMID: 37430148
قاعدة البيانات: MEDLINE
الوصف
تدمد:1435-165X
DOI:10.1007/s00787-023-02256-y