دورية أكاديمية
أعرض في EDS

Harmful effects of chlorhexidine on hepatic metabolism.

التفاصيل البيبلوغرافية
العنوان: Harmful effects of chlorhexidine on hepatic metabolism.
المؤلفون: Pereira-Maróstica HV; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil., Ames-Sibin AP; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil., Pateis VO; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil., de Souza GH; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil., Silva BP; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil., Bracht L; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil., Comar JF; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil., Peralta RM; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil., Bracht A; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil., Sá-Nakanishi AB; Department of Biochemistry, State University of Maringá, Maringá, PR, Brazil. Electronic address: absnakanishi@uem.br.
المصدر: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2023 Sep; Vol. 102, pp. 104217. Date of Electronic Publication: 2023 Jul 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9612020 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7077 (Electronic) Linking ISSN: 13826689 NLM ISO Abbreviation: Environ Toxicol Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier Science B.V., c1996-
مواضيع طبية MeSH: Chlorhexidine*/toxicity , Chlorhexidine*/metabolism , Anti-Infective Agents, Local*, Rats ; Animals ; Rats, Wistar ; Energy Metabolism ; Liver ; Pyruvic Acid/pharmacology ; Mitochondria, Liver
مستخلص: Chlorhexidine (CHX) is an over-the-counter antiseptic amply used by the population. There are reports that CHX acts in mitochondria as an uncoupler and inhibitor. The purpose of this study was to investigate the short-term effects of CHX on hepatic metabolic pathways linked to energy metabolism in the perfused rat liver. The compound inhibited both glucose synthesis and the urea cycle. Oxygen consumption was raised at low concentrations (up to 10 μM) and diminished at higher ones. A pronounced diminution in the cellular ATP content was observed. Conversely, CHX stimulated glycolysis and enhanced leakage of cellular enzymes (lactate dehydrogenase and fumarase). In isolated mitochondria, this antiseptic inhibited pyruvate carboxylation, oxidases, and oxygen uptake at very low concentrations (2 μM) and promoted uncoupling. The results described herein raise great concerns about the safety of CHX, as the observed effects can induce hypoglycemia, lactic acidosis, ammonemia as well as cell membrane disruption.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Adelar Bracht reports financial support was provided by Conselho Nacional de Desenvolvimento Científico e Tecnológico. Adelar Bracht reports a relationship with Conselho Nacional de Desenvolvimento Científico e Tecnológico that includes: funding grants.
(Copyright © 2023 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Antimicrobial; Enzymatic inhibitor; Gluconeogenesis; Mitochondria; Perfused liver
المشرفين على المادة: R4KO0DY52L (Chlorhexidine)
8558G7RUTR (Pyruvic Acid)
0 (Anti-Infective Agents, Local)
تواريخ الأحداث: Date Created: 20230713 Date Completed: 20230913 Latest Revision: 20230913
رمز التحديث: 20231215
DOI: 10.1016/j.etap.2023.104217
PMID: 37442400
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-7077
DOI:10.1016/j.etap.2023.104217