دورية أكاديمية
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Direct Effects of Toxic Divalent Cations on Contractile Proteins with Implications for the Heart: Unraveling Mechanisms of Dysfunction.

التفاصيل البيبلوغرافية
العنوان: Direct Effects of Toxic Divalent Cations on Contractile Proteins with Implications for the Heart: Unraveling Mechanisms of Dysfunction.
المؤلفون: Gerzen OP; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Ekaterinburg, Russia., Votinova VO; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Ekaterinburg, Russia., Potoskueva IK; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Ekaterinburg, Russia., Tzybina AE; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Ekaterinburg, Russia., Nikitina LV; Institute of Immunology and Physiology of the Ural Branch of the Russian Academy of Sciences, 620049 Ekaterinburg, Russia.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Jun 24; Vol. 24 (13). Date of Electronic Publication: 2023 Jun 24.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Contractile Proteins* , Heart*, Cations, Divalent/pharmacology ; Myosins/metabolism ; Cations ; Calcium/pharmacology
مستخلص: The binding of calcium and magnesium ions to proteins is crucial for regulating heart contraction. However, other divalent cations, including xenobiotics, can accumulate in the myocardium and enter cardiomyocytes, where they can bind to proteins. In this article, we summarized the impact of these cations on myosin ATPase activity and EF-hand proteins, with special attention given to toxic cations. Optimal binding to EF-hand proteins occurs at an ionic radius close to that of Mg 2+ and Ca 2+ . In skeletal Troponin C, Cd 2+ , Sr 2+ , Pb 2+ , Mn 2+ , Co 2+ , Ni 2+ , Ba 2+ , Mg 2+ , Zn 2+ , and trivalent lanthanides can substitute for Ca 2+ . As myosin ATPase is not a specific MgATPase, Ca 2+ , Fe 2+ , Mn 2+ , Ni 2+ , and Sr 2+ could support myosin ATPase activity. On the other hand, Zn 2+ and Cu 2 significantly inhibit ATPase activity. The affinity to various divalent cations depends on certain proteins or their isoforms and can alter with amino acid substitution and post-translational modification. Cardiac EF-hand proteins and the myosin ATP-binding pocket are potential molecular targets for toxic cations, which could significantly alter the mechanical characteristics of the heart muscle at the molecular level.
References: Int J Environ Res Public Health. 2017 Jan 12;14(1):. (PMID: 28085104)
Prog Biophys Mol Biol. 1968;18:123-83. (PMID: 4894870)
Chem Res Toxicol. 2019 Jun 17;32(6):1070-1081. (PMID: 30912652)
Food Chem Toxicol. 2019 Mar;125:233-241. (PMID: 30634013)
Biochem Biophys Res Commun. 2005 May 13;330(3):701-5. (PMID: 15809054)
Arch Toxicol. 1990;64(6):490-6. (PMID: 2148867)
Sci Total Environ. 2002 May 6;290(1-3):121-9. (PMID: 12083703)
Gen Physiol Biophys. 2016 Jan;35(1):13-23. (PMID: 26612918)
Food Chem Toxicol. 2020 Oct;144:111641. (PMID: 32758638)
J Muscle Res Cell Motil. 2020 Dec;41(4):313-327. (PMID: 31131433)
Biochemistry. 1971 Dec 7;10(25):4617-24. (PMID: 4258719)
Biochemistry. 2004 Apr 6;43(13):3757-63. (PMID: 15049682)
PLoS One. 2014 May 19;9(5):e96900. (PMID: 24841481)
Curr Opin Struct Biol. 2000 Dec;10(6):637-43. (PMID: 11114499)
Ann Intern Med. 2009 Aug 18;151(4):264-9, W64. (PMID: 19622511)
J Muscle Res Cell Motil. 2020 Mar;41(1):71-89. (PMID: 31030382)
Clin Chim Acta. 2021 Nov;522:1-7. (PMID: 34364855)
J Environ Pathol Toxicol Oncol. 1998;17(3-4):259-64. (PMID: 9726799)
Nat Rev Mol Cell Biol. 2013 Aug;14(8):529-41. (PMID: 23839576)
Food Chem Toxicol. 2022 Nov;169:113444. (PMID: 36179994)
Cytoskeleton (Hoboken). 2021 Jan;78(1):3-13. (PMID: 33381891)
Biochemistry. 1978 Jun 13;17(12):2319-25. (PMID: 678511)
J Expo Sci Environ Epidemiol. 2019 Sep;29(5):633-647. (PMID: 31000792)
J Biochem Mol Toxicol. 2022 Feb;36(2):e22964. (PMID: 34766669)
Arch Environ Contam Toxicol. 2011 Jan;60(1):90-8. (PMID: 20437039)
Toxicology. 2022 Mar 15;469:153136. (PMID: 35202761)
Comput Struct Biotechnol J. 2014 Mar 28;9:e201403002. (PMID: 24757505)
J Inorg Biochem. 2007 Sep;101(9):1251-64. (PMID: 17675161)
Arch Environ Health. 1983 May-Jun;38(3):156-62. (PMID: 6870352)
J Am Coll Cardiol. 1999 May;33(6):1578-83. (PMID: 10334427)
Curr Med Chem. 2005;12(10):1161-208. (PMID: 15892631)
EMBO J. 2007 Jan 10;26(1):265-74. (PMID: 17213877)
J Physiol. 2005 Mar 15;563(Pt 3):689-711. (PMID: 15611022)
Virchows Arch A Pathol Anat Histol. 1980;387(1):67-80. (PMID: 7467117)
J Gen Physiol. 1998 Sep;112(3):297-316. (PMID: 9725890)
J Nutr. 1974 Feb;104(2):239-43. (PMID: 4810985)
Toxicol Appl Pharmacol. 2005 May 1;204(3):274-308. (PMID: 15845419)
Microsyst Nanoeng. 2023 Jan 1;9:2. (PMID: 36597512)
Toxicol Appl Pharmacol. 1992 May;114(1):166-70. (PMID: 1585370)
Orphanet J Rare Dis. 2019 Jan 28;14(1):22. (PMID: 30691535)
Environ Toxicol Chem. 2021 Oct;40(10):2874-2885. (PMID: 34255886)
J Biol Chem. 1984 Dec 25;259(24):15564-71. (PMID: 6210291)
J Appl Toxicol. 2016 Mar;36(3):424-33. (PMID: 26437923)
Inorg Chem. 2018 Dec 3;57(23):14798-14809. (PMID: 30411871)
Biochemistry. 1996 Apr 9;35(14):4409-16. (PMID: 8605190)
Am J Physiol. 1989 Jan;256(1 Pt 2):H195-204. (PMID: 2912182)
Biometals. 2010 Oct;23(5):877-96. (PMID: 20524046)
Braz J Med Biol Res. 2008 Sep;41(9):789-95. (PMID: 18820769)
Environ Int. 2021 Dec;157:106808. (PMID: 34365319)
Biophys J. 1992 Aug;63(2):460-8. (PMID: 1420891)
Lancet. 2018 Feb 3;391(10119):462-512. (PMID: 29056410)
Curr Med Chem. 2012;19(17):2738-59. (PMID: 22455583)
Environ Pollut. 2018 Nov;242(Pt A):814-826. (PMID: 30032078)
Toxicol Appl Pharmacol. 2013 Jan 15;266(2):298-306. (PMID: 23164665)
J Toxicol. 2011;2011:870125. (PMID: 21912545)
Toxicol In Vitro. 2018 Sep;51:106-113. (PMID: 29772264)
Toxicol Sci. 2001 Dec;64(2):243-52. (PMID: 11719707)
Acta Pharmacol Sin. 2020 May;41(5):638-649. (PMID: 31768045)
Biophys Rev. 2017 Oct;9(5):807-825. (PMID: 28836190)
Biophys J. 2000 Mar;78(3):1474-81. (PMID: 10692332)
Acta Pharmacol Sin. 2021 Mar;42(3):340-346. (PMID: 32284539)
Physiol Genomics. 2005 Aug 11;22(3):382-9. (PMID: 15899945)
Zh Evol Biokhim Fiziol. 2011 Jul-Aug;47(4):306-10. (PMID: 21938913)
J Membr Biol. 2003 Sep 15;195(2):93-108. (PMID: 14692449)
J Biol Chem. 2012 Aug 31;287(36):30485-96. (PMID: 22736759)
Biometals. 1998 Sep;11(3):213-22. (PMID: 9850564)
Toxicol Appl Pharmacol. 1999 Apr 15;156(2):113-8. (PMID: 10198276)
J Bioenerg Biomembr. 2003 Dec;35(6):507-32. (PMID: 15000519)
J Biol Chem. 1969 Sep 25;244(18):4995-5004. (PMID: 5824575)
J Inorg Biochem. 2001 Mar;84(1-2):77-88. (PMID: 11330484)
J Mol Biol. 1971 Nov 14;61(3):701-25. (PMID: 4257244)
Mol Aspects Med. 2022 Oct;87:101048. (PMID: 34785060)
Exp Neurol. 1987 Feb;95(2):265-76. (PMID: 3803514)
Am J Physiol Cell Physiol. 2008 Feb;294(2):C495-502. (PMID: 18057121)
Indian J Clin Biochem. 2019 Oct;34(4):371-378. (PMID: 31686724)
Am J Physiol Cell Physiol. 2004 Jul;287(1):C79-87. (PMID: 14985239)
Biol Pharm Bull. 2019;42(7):1076-1082. (PMID: 31257283)
Cardiovasc Toxicol. 2020 Jun;20(3):249-260. (PMID: 31541351)
Metallomics. 2016 Jun 1;8(6):563-78. (PMID: 27108875)
Biometals. 2007 Jun;20(3-4):233-48. (PMID: 17219055)
Metallomics. 2016 Jun 1;8(6):579-88. (PMID: 26745006)
Biometals. 2010 Oct;23(5):811-22. (PMID: 20213268)
Am J Clin Nutr. 1979 May;32(5):967-70. (PMID: 433823)
Anadolu Kardiyol Derg. 2011 Sep;11(6):479-84. (PMID: 21788204)
Environ Health Perspect. 2006 Nov;114(11):1662-9. (PMID: 17107850)
ISRN Toxicol. 2013 Jan 30;2013:184360. (PMID: 23724297)
Biol Trace Elem Res. 2022 Jan;200(1):308-317. (PMID: 33634365)
Acta Physiol Scand. 1997 Jan;159(1):33-40. (PMID: 9124068)
Comp Biochem Physiol C Toxicol Pharmacol. 2003 Jul;135C(3):269-75. (PMID: 12927901)
Ecotoxicol Environ Saf. 2022 Mar 4;234:113329. (PMID: 35255253)
Cells. 2022 Mar 03;11(5):. (PMID: 35269490)
Am J Physiol Heart Circ Physiol. 2000 Nov;279(5):H2259-68. (PMID: 11045961)
Am J Physiol. 1997 May;272(5 Pt 2):H2164-72. (PMID: 9176282)
Braz J Med Biol Res. 2013 Feb;46(2):178-85. (PMID: 23369976)
J Biol Chem. 1995 Mar 24;270(12):6773-8. (PMID: 7896823)
J Inorg Biochem. 2008 Oct;102(10):1901-9. (PMID: 18684507)
J Muscle Res Cell Motil. 2019 Dec;40(3-4):389-398. (PMID: 31556008)
Chemphyschem. 2007 Oct 8;8(14):2119-24. (PMID: 17712827)
J Biol Chem. 2013 Sep 27;288(39):28312-23. (PMID: 23960071)
Environ Monit Assess. 2005 Feb;101(1-3):311-6. (PMID: 15736888)
FEBS Lett. 1975 Oct 15;58(1):197-201. (PMID: 131701)
Q Rev Biophys. 1969 Nov;2(4):351-84. (PMID: 4935801)
Chemosphere. 2022 Mar;291(Pt 1):132771. (PMID: 34740698)
Toxicol Appl Pharmacol. 1973 Jul;25(3):323-31. (PMID: 4738000)
Int J Environ Health Res. 2014 Aug;24(4):378-99. (PMID: 24117228)
Biometals. 2019 Jun;32(3):469-489. (PMID: 30701379)
J Biomed Biotechnol. 2012;2012:949048. (PMID: 22811600)
J Cell Mol Med. 2018 Sep;22(9):4221-4235. (PMID: 29993192)
Neurotoxicology. 2008 Jul;29(4):569-76. (PMID: 18565586)
J Toxicol Environ Health A. 1999 Aug 13;57(7):507-19. (PMID: 10494918)
Toxicol Rep. 2022 Jan 07;9:111-119. (PMID: 35059304)
Lancet. 1998 Oct 3;352(9134):1131-6. (PMID: 9798607)
Environ Sci Pollut Res Int. 2020 Aug;27(23):29266-29279. (PMID: 32436095)
J Appl Toxicol. 1989 Oct;9(5):339-45. (PMID: 2592733)
Exp Mol Pathol. 1975 Jun;22(3):326-34. (PMID: 1126426)
Physiol Genomics. 2005 May 11;21(3):337-42. (PMID: 15713785)
Physiol Rev. 2000 Apr;80(2):853-924. (PMID: 10747208)
J Biol Chem. 1989 Apr 5;264(10):5622-7. (PMID: 2925624)
J Toxicol Clin Toxicol. 1999;37(2):231-7. (PMID: 10382558)
Biomolecules. 2021 Aug 05;11(8):. (PMID: 34439824)
Int J Mol Sci. 2021 Apr 21;22(9):. (PMID: 33919432)
J Hum Hypertens. 2010 Jan;24(1):34-43. (PMID: 20010608)
J Am Heart Assoc. 2017 Feb 1;6(2):. (PMID: 28151401)
Mol Pharmacol. 1984 Jul;26(1):75-82. (PMID: 6087119)
Chest. 1980 Jul;78(1 Suppl):166-73. (PMID: 7398404)
Nat Struct Mol Biol. 2011 Dec 25;19(1):122-7. (PMID: 22198464)
FEBS Lett. 1997 Jan 2;400(1):51-7. (PMID: 9000512)
Toxicology. 2015 May 4;331:119-24. (PMID: 25772431)
Arterioscler Thromb Vasc Biol. 2022 Jan;42(1):87-99. (PMID: 34879710)
J Biomed Res. 2019 May 30;34(2):75-85. (PMID: 32305961)
Arch Toxicol. 1995;69(3):197-203. (PMID: 7717877)
Biophys J. 2016 Jan 5;110(1):7-13. (PMID: 26745404)
Crit Rev Toxicol. 2018 May;48(5):375-386. (PMID: 29431551)
Int J Mol Sci. 2021 Mar 27;22(7):. (PMID: 33801669)
Biochemistry. 1990 Apr 24;29(16):3937-43. (PMID: 2162201)
Toxicol Appl Pharmacol. 1980 Jun 15;54(1):48-56. (PMID: 7394787)
Cell Death Dis. 2023 Feb 11;14(2):105. (PMID: 36774340)
J Inorg Biochem. 2013 Aug;125:40-9. (PMID: 23692958)
Bioinorg Chem. 1976;5(3):253-9. (PMID: 944055)
Sci Am. 1965 Dec;213(6):18-27. (PMID: 5852965)
JACC Case Rep. 2020 Jul 22;2(10):1496-1500. (PMID: 34317004)
ACS Chem Neurosci. 2011 Nov 16;2(11):667-75. (PMID: 22860160)
Biochemistry. 1991 Sep 3;30(35):8690-7. (PMID: 1653605)
Bull Exp Biol Med. 2008 May;145(5):638-41. (PMID: 19145302)
J Gen Physiol. 2022 Dec 5;154(12):. (PMID: 36327149)
J Am Coll Nutr. 1982;1(3):255-62. (PMID: 7185857)
Protein Sci. 2013 Dec;22(12):1766-74. (PMID: 24115140)
J Mol Cell Cardiol. 2014 Jan;66:53-62. (PMID: 24239603)
Mol Cell Proteomics. 2019 Mar;18(3):594-605. (PMID: 30591534)
Toxicol Appl Pharmacol. 1999 Jan 1;154(1):59-66. (PMID: 9882592)
Am J Physiol. 1980 Jul;239(1):H22-30. (PMID: 7396014)
Biochem Pharmacol. 1986 Apr 15;35(8):1331-5. (PMID: 3964302)
J Toxicol Environ Health A. 2006 Nov;69(22):2011-32. (PMID: 17074742)
Am J Kidney Dis. 1985 Nov;6(5):353-7. (PMID: 3904428)
Biophys J. 1998 Mar;74(3):1278-85. (PMID: 9512025)
Biochim Biophys Acta. 1971 Aug 6;245(1):221-9. (PMID: 5132475)
J Gen Physiol. 1997 Apr;109(4):449-61. (PMID: 9101404)
معلومات مُعتمدة: 22-74-00128 Russian Science Foundation
فهرسة مساهمة: Keywords: ATPase activity; EF-hand proteins; cardiotoxicity; divalent cations; heart muscle; myosin; regulatory light chain; toxic ions; troponin C
المشرفين على المادة: 0 (Cations, Divalent)
0 (Contractile Proteins)
EC 3.6.4.1 (Myosins)
0 (Cations)
SY7Q814VUP (Calcium)
تواريخ الأحداث: Date Created: 20230714 Date Completed: 20230717 Latest Revision: 20230718
رمز التحديث: 20230718
مُعرف محوري في PubMed: PMC10341779
DOI: 10.3390/ijms241310579
PMID: 37445756
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms241310579