دورية أكاديمية
Gut-microbiome-brain axis: the crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson's disease.
| العنوان: | Gut-microbiome-brain axis: the crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson's disease. |
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| المؤلفون: | Claudino Dos Santos JC; Christus University Center - UNICHRISTUS, Fortaleza; Postgraduate Program in Morphofunctional Sciences, Federal University of Ceará - UFC, Fortaleza, CE, Brazil., Oliveira LF; Universidade Católica de Brasília - UCB, Brasília, DF, Brasil., Noleto FM; Christus University Center - UNICHRISTUS, Fortaleza, CE, Brazil., Gusmão CTP; Postgraduate Program in Physiology and Pharmacology Department of the Federal University of Ceará - UFC, Fortaleza, CE, Brazil., Brito GAC; Postgraduate Program in Morphofunctional Sciences, Federal University of Ceará - UFC; Physiology and Pharmacology Department of the Federal University of Ceará - UFC, Fortaleza, CE, Brazil, Fortaleza., Viana GSB; Physiology and Pharmacology Department of the Federal University of Ceará - UFC, Fortaleza, CE, Brazil. |
| المصدر: | Neural regeneration research [Neural Regen Res] 2023 Dec; Vol. 18 (12), pp. 2611-2614. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer Health, Medknow Country of Publication: India NLM ID: 101316351 Publication Model: Print Cited Medium: Print ISSN: 1673-5374 (Print) Linking ISSN: 16735374 NLM ISO Abbreviation: Neural Regen Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2013 - : Mumbai : Wolters Kluwer Health, Medknow Original Publication: Shenyang : Editorial Board of Neural Regeneration Research |
| مستخلص: | This critical review of the literature shows that there is a close link between the microbiome, the gut, and the brain in Parkinson's disease. The vagus nerve, the main component of the parasympathetic nervous system, is involved in the regulation of immune response, digestion, heart rate, and control of mood. It can detect microbiota metabolites through its afferents, transferring this gut information to the central nervous system. Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression, as well as treatment responses. These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's disease. More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit. Competing Interests: None |
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| فهرسة مساهمة: | Keywords: Parkinson’s disease; alpha-synuclein; enteric microbiota; gastrointestinal tract; vagus nerve |
| تواريخ الأحداث: | Date Created: 20230714 Latest Revision: 20230722 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10358673 |
| DOI: | 10.4103/1673-5374.373673 |
| PMID: | 37449597 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1673-5374 |
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| DOI: | 10.4103/1673-5374.373673 |