دورية أكاديمية
Trait anxiety is associated with hidden state inference during aversive reversal learning.
| العنوان: | Trait anxiety is associated with hidden state inference during aversive reversal learning. |
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| المؤلفون: | Zika O; Max Planck Research Group NeuroCode, Max Planck Institute for Human Development, Berlin, Germany. zika@mpib-berlin.mpg.de.; Max Planck UCL Centre for Computational Psychiatry and Aging Research, Berlin, Germany. zika@mpib-berlin.mpg.de., Wiech K; Wellcome Centre for Integrative Neuroimaging (WIN), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Reinecke A; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Trust, Warneford Hospital, Oxford, UK., Browning M; Department of Psychiatry, University of Oxford, Oxford, UK.; Oxford Health NHS Trust, Warneford Hospital, Oxford, UK., Schuck NW; Max Planck Research Group NeuroCode, Max Planck Institute for Human Development, Berlin, Germany. schuck@mpib-berlin.mpg.de.; Max Planck UCL Centre for Computational Psychiatry and Aging Research, Berlin, Germany. schuck@mpib-berlin.mpg.de.; Institute of Psychology, Universität Hamburg, Hamburg, Germany. schuck@mpib-berlin.mpg.de. |
| المصدر: | Nature communications [Nat Commun] 2023 Jul 14; Vol. 14 (1), pp. 4203. Date of Electronic Publication: 2023 Jul 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Pub. Group |
| مواضيع طبية MeSH: | Reversal Learning* , Conditioning, Classical*, Humans ; Anxiety ; Fear ; Anxiety Disorders |
| مستخلص: | Updating beliefs in changing environments can be driven by gradually adapting expectations or by relying on inferred hidden states (i.e. contexts), and changes therein. Previous work suggests that increased reliance on context could underly fear relapse phenomena that hinder clinical treatment of anxiety disorders. We test whether trait anxiety variations in a healthy population influence how much individuals rely on hidden-state inference. In a Pavlovian learning task, participants observed cues that predicted an upcoming electrical shock with repeatedly changing probability, and were asked to provide expectancy ratings on every trial. We show that trait anxiety is associated with steeper expectation switches after contingency reversals and reduced oddball learning. Furthermore, trait anxiety is related to better fit of a state inference, compared to a gradual learning, model when contingency changes are large. Our findings support previous work suggesting hidden-state inference as a mechanism behind anxiety-related to fear relapse phenomena. (© 2023. The Author(s).) |
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| معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust |
| تواريخ الأحداث: | Date Created: 20230714 Date Completed: 20230717 Latest Revision: 20231118 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC10349120 |
| DOI: | 10.1038/s41467-023-39825-3 |
| PMID: | 37452030 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2041-1723 |
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| DOI: | 10.1038/s41467-023-39825-3 |