دورية أكاديمية
Influence of polymorphic variations of IFNL, HLA, and IL-6 genes in severe cases of COVID-19.
| العنوان: | Influence of polymorphic variations of IFNL, HLA, and IL-6 genes in severe cases of COVID-19. |
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| المؤلفون: | Araújo A; Laboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia (FIOCRUZ/RO), Porto Velho 76812-329, Brazil.; Centro de Pesquisa em Medicina Tropical (CEPEM), Porto Velho 76812-329, Brazil., Sgorlon G; Laboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia (FIOCRUZ/RO), Porto Velho 76812-329, Brazil.; Centro de Pesquisa em Medicina Tropical (CEPEM), Porto Velho 76812-329, Brazil.; Programa de Pós-Graduação em Biologia Experimental, Universidade Federal de Rondônia (UNIR), Porto Velho 76801-059, Brazil., Aguiar LE; Faculdades Integradas Aparício Carvalho (FIMCA), Porto Velho 76811-678, Brazil., Cidrão MHMC; Faculdades Integradas Aparício Carvalho (FIMCA), Porto Velho 76811-678, Brazil., Teixeira KS; Laboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia (FIOCRUZ/RO), Porto Velho 76812-329, Brazil.; Centro de Pesquisa em Medicina Tropical (CEPEM), Porto Velho 76812-329, Brazil., Villalobos Salcedo JM; Laboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia (FIOCRUZ/RO), Porto Velho 76812-329, Brazil.; Universidade Federal de Rondônia (UNIR), Porto Velho 76801-059, Brazil., Passos-Silva AM; Laboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia (FIOCRUZ/RO), Porto Velho 76812-329, Brazil.; Centro de Pesquisa em Medicina Tropical (CEPEM), Porto Velho 76812-329, Brazil.; Programa de Pós-Graduação em Biologia Experimental, Universidade Federal de Rondônia (UNIR), Porto Velho 76801-059, Brazil., Vieira D; Laboratório de Virologia Molecular, Fundação Oswaldo Cruz Rondônia (FIOCRUZ/RO), Porto Velho 76812-329, Brazil.; Centro de Pesquisa em Medicina Tropical (CEPEM), Porto Velho 76812-329, Brazil.; Programa de Pós-Graduação em Biologia Experimental, Universidade Federal de Rondônia (UNIR), Porto Velho 76801-059, Brazil. |
| المصدر: | Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2023 May; Vol. 248 (9), pp. 787-797. Date of Electronic Publication: 2023 Jul 15. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S.A Country of Publication: England NLM ID: 100973463 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3699 (Electronic) Linking ISSN: 15353699 NLM ISO Abbreviation: Exp Biol Med (Maywood) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : Lausanne, Switzerland : Frontiers Media S.A. Original Publication: Maywood, NJ : The Society, c2001- |
| مواضيع طبية MeSH: | COVID-19*/genetics , Liver Neoplasms*, Humans ; Disease Progression ; Genotype ; HLA Antigens/genetics ; Interleukin-6/genetics ; Interleukins/genetics ; Polymorphism, Single Nucleotide/genetics |
| مستخلص: | The administration of vaccination doses to the global population has led to a decrease in the incidence of COVID-19. However, the clinical picture developed by infected individuals remains extremely concerning due to the great variability in the severity of cases even in vaccinated individuals. The clinical progression of the pathology is characterized by various influential factors such as sex, age group, comorbidities, and the genetics of the individual. The immune response to viral infections can be strongly influenced by the genetics of individuals; nucleotide variations called single-nucleotide polymorphisms (SNPs) in structures involved in the innate and adaptive immune response such as interferon (IFN)-λ, human leukocyte antigen (HLA), and interleukin (IL)-6 are frequently associated with pathological progression. In this study, we conducted a review of the main SNPs of these structures that are associated with severity in COVID-19. Searches were conducted on some platforms of the National Center for Biotechnology and Information (NCBI), and 102 studies were selected for full reading according to the inclusion criteria. IFNs showed a strong association with antiviral function, specifically, IFN-λ3 (IL-28B) demonstrated genetic variants commonly related to clinical progression in various pathologies. For COVID-19, rs12979860 and rs1298275 presented frequently described unfavorable genotypes for pathological conditions of hepatitis C and hepatocellular carcinoma. The high genetic variability of HLA was reported in the studies as a crucial factor relevant to the late immune response, mainly due to its ability to recognize antigens, with the HLA-B*46:01 SNP being associated with susceptibility to COVID-19. For IL-6, rs1554606 showed a strong relationship with the clinical progression of COVID-19. In addition, rs2069837 was identified with possible host protection relationships when linked to this infection. |
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| فهرسة مساهمة: | Keywords: COVID-19; HLA; IFN-λ; IL-6; Immunogenetic; polymorphism |
| المشرفين على المادة: | 0 (HLA Antigens) 0 (Interleukin-6) 0 (Interleukins) 0 (IL6 protein, human) |
| تواريخ الأحداث: | Date Created: 20230715 Date Completed: 20230822 Latest Revision: 20231106 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10350587 |
| DOI: | 10.1177/15353702231181343 |
| PMID: | 37452704 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1535-3699 |
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| DOI: | 10.1177/15353702231181343 |