دورية أكاديمية
أعرض في EDS

The ameliorative effect of bergamot oil nano-emulsion in stressed rabbit bucks: Influence on blood biochemical parameters, redox status, immunity indices, inflammation markers, semen quality, testicular changes and the expression of HSPs genes.

التفاصيل البيبلوغرافية
العنوان: The ameliorative effect of bergamot oil nano-emulsion in stressed rabbit bucks: Influence on blood biochemical parameters, redox status, immunity indices, inflammation markers, semen quality, testicular changes and the expression of HSPs genes.
المؤلفون: Saghir SAM; Department of Medical Analysis. Princess Aisha Bint Al-Hussein College of Nursing and Medical Sciences, Al-Hussein Bin Talal University, Ma'an 71111, Jordan., Alnaimat SM; Department of Medical Analysis. Princess Aisha Bint Al-Hussein College of Nursing and Medical Sciences, Al-Hussein Bin Talal University, Ma'an 71111, Jordan.; Department of Biology Department, Al-Hussein Bin Talal University, Ma'an, Jordan., Dmour SM; Department of Medical Analysis. Princess Aisha Bint Al-Hussein College of Nursing and Medical Sciences, Al-Hussein Bin Talal University, Ma'an 71111, Jordan., Al-Tarawni AH; Department of Biological Sciences, Mutah University, Al-Karak, Jordan., Abdelnour SA; Department of Animal Production, Faculty of Agriculture, Zagazig University, 44519 Zagazig, Egypt., Ahmeda AF; Department of Basic Medical Sciences, College of Medicine, Ajman University, Ajman 346, United Arab Emirates.; Center of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman 346, United Arab Emirates., Arisha AH; Department of Animal Physiology and Biochemistry, Faculty of Veterinary Medicine, Badr University in Cairo, Badr City 11829, Egypt.; Department of Physiology, Laboratory of Biotechnology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44519, Egypt., Hawwal MF; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Alanzi AR; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Mothana RA; Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia., Lindequist U; Department of Pharmaceutical Biology, Institute of Pharmacy, University of Greifswald, Greifswald, Germany.
المصدر: Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society [Saudi Pharm J] 2023 Aug; Vol. 31 (8), pp. 101691. Date of Electronic Publication: 2023 Jun 28.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Saudi Pharmaceutical Society Country of Publication: Saudi Arabia NLM ID: 9705695 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1319-0164 (Print) Linking ISSN: 13190164 NLM ISO Abbreviation: Saudi Pharm J Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Riyadh : Saudi Pharmaceutical Society
Original Publication: Riyadh, Kingdom of Saudi Arabia : The Society,
مستخلص: This work explored the activities of bergamot oil nano-emulsion (NBG) in modulating blood biochemical parameters, redox status, immunity indices, inflammation markers, semen quality, testicular changes and the expression of HSPs genes in stressed rabbit bucks. Twenty-four mature rabbit bucks (5 months) were randomly divided into three groups; control group (NBG0) received 1 ml of distilled water, while the other two groups received NBG orally at doses of 50 and 100 mg/kg (bw) twice a week. The present study's findings revealed that treated groups had lower values of total and direct bilirubin, triglyceride, lactate dehydrogenase, and creatinine compared with NBG0 group ( p  < 0.05). NBG100 group recorded the greatest of total protein, albumin, GPx, T3 and T4 values as well as the lowest values of uric acid, MDA, and indirect bilirubin. Both treated groups showed significantly reduced 8-OhDG, Amyloid A, TLR 4, while significantly increased nitric oxide, IgA, IgM, TAC, and SOD levels. Semen characteristics such as volume, sperm count, sperm motility, normal sperm, and vitality were significantly higher in the NBG100 group compared to the NBG50 and NBG0 groups, whereas sperm abnormalities and dead sperm were significantly reduced. HSP70, HSP72, and HSPA9 gene overexpression showed that testicular integrity was maintained after buck received oral doses of 50 or 100 mg/kg of NBG. Existing findings indicate that oral administration of NBG improves heat tolerance in rabbit bucks primarily as e result of its antioxidant and anti-inflammatory effects.
Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2023 The Author(s).)
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فهرسة مساهمة: Keywords: Bergamot oil nano-emulsion; Citrus bergamia; Heat stress; Inflammation; Oxidative stress; Rabbit bucks; Semen quality
تواريخ الأحداث: Date Created: 20230717 Latest Revision: 20230718
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10345481
DOI: 10.1016/j.jsps.2023.06.024
PMID: 37457368
قاعدة البيانات: MEDLINE
الوصف
تدمد:1319-0164
DOI:10.1016/j.jsps.2023.06.024