دورية أكاديمية
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Hypolipidaemic effects of papaya ( Carica papaya L.) juice on rats fed on a high fat and fructose diet.

التفاصيل البيبلوغرافية
العنوان: Hypolipidaemic effects of papaya ( Carica papaya L.) juice on rats fed on a high fat and fructose diet.
المؤلفون: Matsuane C; Department of Horticulture and Food Security, Jomo Kenyatta University of Agriculture and Technology, P.O. Box, Nairobi 62000-00200, Kenya.; Department of Crop and Soil Sciences, Botswana University of Agriculture and Natural Resources, Private Bag 0027, Gaborone, Botswana., Kiage BN; Department of Human Nutrition, Jomo Kenyatta University of Agriculture and Technology, P.O. Box, Nairobi 62000-00200, Kenya., Karanja J; Department of Horticulture and Food Security, Jomo Kenyatta University of Agriculture and Technology, P.O. Box, Nairobi 62000-00200, Kenya., Kavoo AM; Department of Horticulture and Food Security, Jomo Kenyatta University of Agriculture and Technology, P.O. Box, Nairobi 62000-00200, Kenya., Rimberia FK; Department of Horticulture and Food Security, Jomo Kenyatta University of Agriculture and Technology, P.O. Box, Nairobi 62000-00200, Kenya.
المصدر: Journal of nutritional science [J Nutr Sci] 2023 Jul 10; Vol. 12, pp. e76. Date of Electronic Publication: 2023 Jul 10 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cambridge University Press Country of Publication: England NLM ID: 101590587 Publication Model: eCollection Cited Medium: Internet ISSN: 2048-6790 (Electronic) Linking ISSN: 20486790 NLM ISO Abbreviation: J Nutr Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge : Cambridge University Press, 2012-
مواضيع طبية MeSH: Carica* , Hyperlipidemias*/drug therapy , Hypercholesterolemia*, Rats ; Male ; Animals ; Cholesterol, LDL ; Fructose ; Diet, High-Fat/adverse effects ; Rats, Wistar ; Obesity/drug therapy ; Vegetables
مستخلص: Papaya ( Carica papaya L.) is a highly nutritious and less-caloric fruit, commonly consumed for its minerals and vitamins and hence may help in controlling obesity and abdominal discomforts. The present study investigated the hypolipidaemic effects of papaya juice extract on male Albino Wistar rats (7 weeks old; 185 ± 17 g) fed on a high fat and fructose diet (HFFD) for 6 weeks. The rats were divided into groups I-IV of five rats each and fed on either a HFFD (i.e. the Control), HFFD + 200 mg papaya, HFFD + 350 mg papaya or a HFFD + 500 mg papaya. On day 34, after an overnight fast, blood samples were obtained by cardiac puncture under 99⋅8 % Chloroform anaesthesia for the determination of serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and high-density cholesterol (HDL-c). The atherogenic (AI) and coronary risk (CRI) indices were also calculated. Statistical analysis was performed using ANOVA where means were separated using Tukey's HSD test. Resulted showed that all rats given papaya juice had an increasing, non-significant HDL-c and reduced LDL-c levels while rats fed on HFFD had the highest TC (53⋅2 mg/dl) and TG (37⋅6 mg/dl) levels. Papaya juice statistically reduced the AI and CRI of the rats. In conclusion, consumption of HFFD + 500 mg was the most effective in the reduction of rats' blood lipids and fats, due to its anti-obesity and hypolipidaemic properties, thus can be used in the management of dyspilidaemic disorders.
(© The Author(s) 2023.)
References: Arteriosclerosis. 1988 May-Jun;8(3):207-11. (PMID: 3370018)
Afr Health Sci. 2011 Mar;11(1):85-9. (PMID: 21572862)
J Agric Food Chem. 2003 Apr 9;51(8):2144-55. (PMID: 12670148)
J Food Sci Technol. 2015 Aug;52(8):5299-304. (PMID: 26243956)
Biomed Rep. 2020 Oct;13(4):30. (PMID: 32802327)
Malays J Med Sci. 2017 Oct;24(5):101-105. (PMID: 29386977)
Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2374-9. (PMID: 20561945)
J Pharm Biomed Anal. 2007 Jan 17;43(2):527-32. (PMID: 16971083)
Front Neurol. 2021 Oct 11;12:741754. (PMID: 34707558)
J Nutr. 2001 Apr;131(4):1129-32. (PMID: 11285313)
Curr Med Chem. 2017;24(4):355-364. (PMID: 27633685)
Exp Anim. 2015;64(4):435-42. (PMID: 26134356)
Nutr Metab (Lond). 2015 Dec 23;12:60. (PMID: 26705405)
Biomolecules. 2019 Sep 01;9(9):. (PMID: 31480505)
Clin Chem. 1972 Jun;18(6):499-502. (PMID: 4337382)
ScientificWorldJournal. 2012;2012:436039. (PMID: 22666121)
Nutrients. 2018 Sep 14;10(9):. (PMID: 30223482)
Nutrients. 2018 Oct 14;10(10):. (PMID: 30322196)
Food Technol Biotechnol. 2015 Jun;53(2):171-179. (PMID: 27904346)
Int J Mol Sci. 2021 Sep 14;22(18):. (PMID: 34576066)
J Am Assoc Lab Anim Sci. 2012 Jan;51(1):25-30. (PMID: 22330864)
Metab Syndr Relat Disord. 2014 Jun;12(5):258-68. (PMID: 24512556)
Phytother Res. 2012 Dec;26(12):1878-83. (PMID: 22431070)
Nutrients. 2019 Jul 16;11(7):. (PMID: 31315213)
فهرسة مساهمة: Keywords: Blood lipids; High fat and fructose diet; Hypolipidaemic; Papaya (Carica papaya L.)
المشرفين على المادة: 0 (Cholesterol, LDL)
30237-26-4 (Fructose)
تواريخ الأحداث: Date Created: 20230717 Date Completed: 20230718 Latest Revision: 20230719
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10345780
DOI: 10.1017/jns.2023.61
PMID: 37457684
قاعدة البيانات: MEDLINE
الوصف
تدمد:2048-6790
DOI:10.1017/jns.2023.61