دورية أكاديمية
أعرض في EDS

Heart rate stability in a clinical setting and after a short exercise in healthy male volunteers.

التفاصيل البيبلوغرافية
العنوان: Heart rate stability in a clinical setting and after a short exercise in healthy male volunteers.
المؤلفون: Wildenbeest FWH; Centre for Human Drug Research, Leiden, The Netherlands., Hassing GJ; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands., Kemme MJB; Department of Cardiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands., Moerland M; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands., Gal P; Centre for Human Drug Research, Leiden, The Netherlands.; Leiden University Medical Center, Leiden, The Netherlands.
المصدر: Clinical physiology and functional imaging [Clin Physiol Funct Imaging] 2024 Jan; Vol. 44 (1), pp. 36-43. Date of Electronic Publication: 2023 Aug 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Country of Publication: England NLM ID: 101137604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1475-097X (Electronic) Linking ISSN: 14750961 NLM ISO Abbreviation: Clin Physiol Funct Imaging Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Blackwell, c2002-
مواضيع طبية MeSH: Electrocardiography* , Volunteers*, Humans ; Male ; Heart Rate/physiology ; Healthy Volunteers ; Double-Blind Method
مستخلص: Introduction: Limited data exist on heart rate stabilization in the domiciled nature of phase I clinical studies, particularly when frequent measurements of QT intervals are involved. The present analysis aimed to evaluate heart rate stability in the domiciled nature of, and stabilization after a short exercise.
Methods: Fifty-six healthy male subjects were included in this analysis. Data during a domiciled clinical setting and after a short exercise were analysed. Mean values of 30 s intervals of collected electrocardiographical data (PR, RR, QT and QTcF intervals) during a 10-min supine resting period in a domiciled nature or after walking up and down three stories (100 steps) were compared to baseline values using paired t-tests or compared to the intrasubject standard deviation.
Results: Stable heart rates and stable QTcF intervals observed immediately upon assuming a supine position in the domiciled clinical setting. After the short exercise, PR interval and RR interval were significantly (p < 0.05) shorter for up to 120 s (mean value -9.8 ± 7.2 ms) and 30 s (-160 ± 165 ms, p < 0.05), respectively. QT and QTcF intervals were significantly (p < 0.05) shorter for up to 90 and 120 s postexercise, respectively. Both QT and QTcF intervals stabilized after 2 min, but QT interval remained prolonged while QTcF interval returned to baseline levels.
Conclusion: In a clinical setting, male volunteers do not require a waiting period for electrocardiographic parameter normalization. However, accurate measurement of these parameters following a short exercise necessitates a minimum 2-min resting interval.
(© 2023 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine.)
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فهرسة مساهمة: Keywords: ECG; QTcF interval; RR interval; electrophysiology; repolarization
تواريخ الأحداث: Date Created: 20230717 Date Completed: 20231207 Latest Revision: 20231207
رمز التحديث: 20231215
DOI: 10.1111/cpf.12846
PMID: 37458374
قاعدة البيانات: MEDLINE
الوصف
تدمد:1475-097X
DOI:10.1111/cpf.12846