دورية أكاديمية
أعرض في EDS

Ancestry-driven metabolite variation provides insights into disease states in admixed populations.

التفاصيل البيبلوغرافية
العنوان: Ancestry-driven metabolite variation provides insights into disease states in admixed populations.
المؤلفون: Reynolds KM; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA.; Department of Epidemiology, University of North Carolina, 123 W Franklin St, Suite 401, NC, NC 27516, Chapel Hill, USA., Horimoto ARVR; Department of Biostatistics, University of Washington, Seattle, WA, USA., Lin BM; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA., Zhang Y; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Kurniansyah N; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Yu B; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Boerwinkle E; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Qi Q; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA., Kaplan R; Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Daviglus M; Institute for Minority Health Research, University of Illinois at Chicago, Chicago, IL, USA., Hou L; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Zhou LY; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA., Cai J; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA., Shaikh SR; Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA., Sofer T; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Departments of Medicine and Biostatistics, Harvard University, Boston, MA, USA., Browning SR; Department of Biostatistics, University of Washington, Seattle, WA, USA., Franceschini N; Department of Epidemiology, University of North Carolina, 123 W Franklin St, Suite 401, NC, NC 27516, Chapel Hill, USA. noraf@unc.edu.
المصدر: Genome medicine [Genome Med] 2023 Jul 17; Vol. 15 (1), pp. 52. Date of Electronic Publication: 2023 Jul 17.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central
مواضيع طبية MeSH: Genome-Wide Association Study*/methods , Hispanic or Latino*/genetics , Tandem Mass Spectrometry*, Humans ; Black People/genetics ; Genome, Human ; Polymorphism, Single Nucleotide ; American Indian or Alaska Native/genetics ; Metabolism/genetics ; Population Groups/ethnology ; Population Groups/genetics
مستخلص: Background: Metabolic pathways are related to physiological functions and disease states and are influenced by genetic variation and environmental factors. Hispanics/Latino individuals have ancestry-derived genomic regions (local ancestry) from their recent admixture that have been less characterized for associations with metabolite abundance and disease risk.
Methods: We performed admixture mapping of 640 circulating metabolites in 3887 Hispanic/Latino individuals from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). Metabolites were quantified in fasting serum through non-targeted mass spectrometry (MS) analysis using ultra-performance liquid chromatography-MS/MS. Replication was performed in 1856 nonoverlapping HCHS/SOL participants with metabolomic data.
Results: By leveraging local ancestry, this study identified significant ancestry-enriched associations for 78 circulating metabolites at 484 independent regions, including 116 novel metabolite-genomic region associations that replicated in an independent sample. Among the main findings, we identified Native American enriched genomic regions at chromosomes 11 and 15, mapping to FADS1/FADS2 and LIPC, respectively, associated with reduced long-chain polyunsaturated fatty acid metabolites implicated in metabolic and inflammatory pathways. An African-derived genomic region at chromosome 2 was associated with N-acetylated amino acid metabolites. This region, mapped to ALMS1, is associated with chronic kidney disease, a disease that disproportionately burdens individuals of African descent.
Conclusions: Our findings provide important insights into differences in metabolite quantities related to ancestry in admixed populations including metabolites related to regulation of lipid polyunsaturated fatty acids and N-acetylated amino acids, which may have implications for common diseases in populations.
(© 2023. The Author(s).)
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معلومات مُعتمدة: N01HC65235 United States HL NHLBI NIH HHS; N01HC65233 United States HL NHLBI NIH HHS; P30 DK020541 United States DK NIDDK NIH HHS; R01 MD012765 United States MD NIMHD NIH HHS; P30 ES010126 United States ES NIEHS NIH HHS; N01HC65236 United States HL NHLBI NIH HHS; N01HC65237 United States HL NHLBI NIH HHS; R01 DK117445 United States DK NIDDK NIH HHS; N01HC65234 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: Admixture mapping; Hispanics/Latino populations; Local ancestry; Metabolites
تواريخ الأحداث: Date Created: 20230717 Date Completed: 20230725 Latest Revision: 20240426
رمز التحديث: 20240426
مُعرف محوري في PubMed: PMC10351197
DOI: 10.1186/s13073-023-01209-z
PMID: 37461045
قاعدة البيانات: MEDLINE
الوصف
تدمد:1756-994X
DOI:10.1186/s13073-023-01209-z