دورية أكاديمية
Impact of Plasmodium falciparum infection on DNA methylation of circulating immune cells.
| العنوان: | Impact of Plasmodium falciparum infection on DNA methylation of circulating immune cells. |
|---|---|
| المؤلفون: | Almojil D; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates., Diawara A; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates., Soulama I; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Dieng MM; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates., Manikandan V; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates., Sermé SS; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Sombié S; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Diarra A; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Barry A; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Coulibaly SA; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Sirima SB; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Idaghdour Y; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates. |
| المصدر: | Frontiers in genetics [Front Genet] 2023 Jul 04; Vol. 14, pp. 1197933. Date of Electronic Publication: 2023 Jul 04 (Print Publication: 2023). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101560621 Publication Model: eCollection Cited Medium: Print ISSN: 1664-8021 (Print) Linking ISSN: 16648021 NLM ISO Abbreviation: Front Genet Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation. |
| مستخلص: | The regulation of immune cell responses to infection is a complex process that involves various molecular mechanisms, including epigenetic regulation. DNA methylation has been shown to play central roles in regulating gene expression and modulating cell response during infection. However, the nature and extent to which DNA methylation is involved in the host immune response in human malaria remains largely unknown. Here, we present a longitudinal study investigating the temporal dynamics of genome-wide in vivo DNA methylation profiles using 189 MethylationEPIC 850 K profiles from 66 children in Burkina Faso, West Africa, sampled three times: before infection, during symptomatic parasitemia, and after malaria treatment. The results revealed major changes in the DNA methylation profiles of children in response to both Plasmodium falciparum infection and malaria treatment, with widespread hypomethylation of CpGs upon infection (82% of 6.8 K differentially methylated regions). We document a remarkable reversal of CpG methylation profiles upon treatment to pre-infection states. These changes implicate divergence in core immune processes, including the regulation of lymphocyte, neutrophil, and myeloid leukocyte function. Integrative DNA methylation-mRNA analysis of a top differentially methylated region overlapping the pro-inflammatory gene TNF implicates DNA methylation of TNF cis regulatory elements in the molecular mechanisms of TNF regulation in human malaria. Our results highlight a central role of epigenetic regulation in mounting the host immune response to P. falciparum infection and in response to malaria treatment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Almojil, Diawara, Soulama, Dieng, Manikandan, Sermé, Sombié, Diarra, Barry, Coulibaly, Sirima and Idaghdour.) |
| References: | Immunol Rev. 2020 Jan;293(1):115-143. (PMID: 31608461) J Immunol. 2006 Apr 1;176(7):4323-30. (PMID: 16547269) Front Immunol. 2018 Dec 19;9:3005. (PMID: 30619354) Genome Res. 2003 Nov;13(11):2498-504. (PMID: 14597658) Curr Opin Immunol. 2020 Aug;65:7-13. (PMID: 32220702) Int J Mol Sci. 2022 Apr 27;23(9):. (PMID: 35563239) Bioinformatics. 2016 Jan 15;32(2):286-8. (PMID: 26424855) Hum Mol Genet. 2005 Jan 15;14(2):319-26. (PMID: 15574462) Aging (Albany NY). 2018 Jul 26;10(7):1758-1775. (PMID: 30048243) J Exp Med. 1993 May 1;177(5):1277-86. (PMID: 8386742) Am J Hum Genet. 2001 Sep;69(3):504-15. (PMID: 11462172) Clin Epigenetics. 2022 Dec 15;14(1):173. (PMID: 36522672) Aging (Albany NY). 2020 Nov 9;12(21):21037-21056. (PMID: 33168783) Genome Res. 2002 Aug;12(8):1246-56. (PMID: 12176932) PLoS Pathog. 2012;8(11):e1003007. (PMID: 23209403) Ann Clin Lab Sci. 1985 Nov-Dec;15(6):465-9. (PMID: 3904592) PLoS Pathog. 2014 Oct 09;10(10):e1004419. (PMID: 25299267) Trends Parasitol. 2017 May;33(5):364-377. (PMID: 28065669) BMC Bioinformatics. 2012 May 08;13:86. (PMID: 22568884) Front Immunol. 2018 Dec 14;9:2961. (PMID: 30619319) Clin Epigenetics. 2021 Nov 16;13(1):205. (PMID: 34784966) Syst Parasitol. 2005 May;61(1):47-52. (PMID: 15928991) J Travel Med. 2022 Jul 14;29(4):. (PMID: 35467747) Blood Adv. 2021 Nov 23;5(22):4710-4720. (PMID: 34470050) Infect Immun. 2011 Jun;79(6):2379-84. (PMID: 21422175) Bioinformatics. 2014 May 15;30(10):1363-9. (PMID: 24478339) Front Genet. 2019 Jan 09;9:695. (PMID: 30687383) Brief Bioinform. 2019 Nov 27;20(6):2224-2235. (PMID: 30239597) Cold Spring Harb Perspect Med. 2017 Jul 5;7(7):. (PMID: 28320828) Exp Mol Med. 2017 Apr 28;49(4):e322. (PMID: 28450738) Aging (Albany NY). 2019 Nov 22;11(22):10031-10051. (PMID: 31756171) Genome Res. 2015 Dec;25(12):1801-11. (PMID: 26392366) J Parasitol. 2014 Feb;100(1):11-25. (PMID: 24059436) Genome Res. 2013 Dec;23(12):2030-41. (PMID: 24013550) Nat Metab. 2021 Jul;3(7):1001-1016. (PMID: 34113019) Cancer Res. 2005 Mar 15;65(6):2115-24. (PMID: 15781621) Nat Rev Cancer. 2004 Feb;4(2):143-53. (PMID: 14732866) Nat Immunol. 2015 Jul;16(7):675-9. (PMID: 26086132) Epigenetics Chromatin. 2015 Jan 27;8:6. (PMID: 25972926) Immunol Rev. 2020 Jan;293(1):8-24. (PMID: 31840836) Gastroenterology. 2019 Jun;156(8):2254-2265.e3. (PMID: 30779925) PLoS Genet. 2011 Sep;7(9):e1002300. (PMID: 21980303) Mol Syst Biol. 2022 Apr;18(4):e10824. (PMID: 35475529) Parasit Vectors. 2010 Feb 01;3(1):5. (PMID: 20205846) Malar J. 2012 May 04;11:154. (PMID: 22559271) Mol Ecol. 2014 Sep;23(17):4256-73. (PMID: 24943398) Int J Parasitol. 2022 Oct;52(11):717-720. (PMID: 35905779) Front Microbiol. 2017 Jan 11;7:2155. (PMID: 28123381) Genome Biol. 2016 Oct 7;17(1):208. (PMID: 27717381) J Exp Med. 1996 Oct 1;184(4):1397-411. (PMID: 8879212) Immunol Lett. 1990 Aug;25(1-3):213-6. (PMID: 2283152) Nat Immunol. 2015 Jul;16(7):746-54. (PMID: 26030024) J Physiol Anthropol. 2021 Jan 7;40(1):1. (PMID: 33413683) Nature. 1994 Oct 6;371(6497):508-10. (PMID: 7935762) Med Res Rev. 2022 May;42(3):1343-1371. (PMID: 34984701) Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16786-93. (PMID: 22949651) J Infect Dis. 2009 Feb 15;199(4):569-75. (PMID: 19281305) BMC Infect Dis. 2013 Nov 12;13:535. (PMID: 24215306) J Clin Invest. 2017 Aug 1;127(8):3065-3074. (PMID: 28714864) PLoS One. 2017 Apr 19;12(4):e0175702. (PMID: 28422980) J Immunol. 2018 Feb 15;200(4):1243-1248. (PMID: 29330325) Front Cell Infect Microbiol. 2021 Dec 16;11:793954. (PMID: 34976869) Front Immunol. 2019 Apr 18;10:856. (PMID: 31057561) Cell Mol Life Sci. 2020 Jun;77(11):2141-2156. (PMID: 31492965) Ann Intern Med. 2001 Apr 3;134(7):573-86. (PMID: 11281740) Nat Commun. 2020 Oct 9;11(1):5093. (PMID: 33037226) Front Immunol. 2018 Aug 03;9:1733. (PMID: 30158923) Trends Mol Med. 2017 Apr;23(4):332-347. (PMID: 28291707) Immunology. 2013 Jul;139(3):285-93. (PMID: 23521628) Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6938-6943. (PMID: 30886108) Biomolecules. 2022 Feb 25;12(3):. (PMID: 35327559) Nat Rev Genet. 2012 May 29;13(7):484-92. (PMID: 22641018) Nat Biotechnol. 2013 Feb;31(2):142-7. (PMID: 23334450) Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23329-23335. (PMID: 31611402) J Immunol. 2018 Mar 15;200(6):1965-1975. (PMID: 29507121) Semin Immunol. 2016 Apr;28(2):119-28. (PMID: 27151246) Cell Microbiol. 2015 Aug;17(8):1121-32. (PMID: 26096716) Front Immunol. 2022 May 06;13:883410. (PMID: 35603204) Cancer Res. 2003 Jul 15;63(14):4158-66. (PMID: 12874021) Int J Mol Sci. 2018 Feb 03;19(2):. (PMID: 29401667) Immunol Cell Biol. 2015 Mar;93(3):226-32. (PMID: 25666097) Genes Chromosomes Cancer. 2006 Jul;45(7):656-67. (PMID: 16575877) |
| فهرسة مساهمة: | Keywords: DNA methyaltion; Plasmodium falciparum; TNF; host parasite interactions; malaria; methylome |
| تواريخ الأحداث: | Date Created: 20230720 Latest Revision: 20230721 |
| رمز التحديث: | 20230721 |
| مُعرف محوري في PubMed: | PMC10352500 |
| DOI: | 10.3389/fgene.2023.1197933 |
| PMID: | 37470040 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-8021 |
|---|---|
| DOI: | 10.3389/fgene.2023.1197933 |