دورية أكاديمية
Impact of Plasmodium falciparum infection on DNA methylation of circulating immune cells.
العنوان: | Impact of Plasmodium falciparum infection on DNA methylation of circulating immune cells. |
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المؤلفون: | Almojil D; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates., Diawara A; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates., Soulama I; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Dieng MM; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates., Manikandan V; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates., Sermé SS; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Sombié S; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Diarra A; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Barry A; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Coulibaly SA; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Sirima SB; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso., Idaghdour Y; Program in Biology, Division of Science and Mathematics, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates. |
المصدر: | Frontiers in genetics [Front Genet] 2023 Jul 04; Vol. 14, pp. 1197933. Date of Electronic Publication: 2023 Jul 04 (Print Publication: 2023). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101560621 Publication Model: eCollection Cited Medium: Print ISSN: 1664-8021 (Print) Linking ISSN: 16648021 NLM ISO Abbreviation: Front Genet Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation. |
مستخلص: | The regulation of immune cell responses to infection is a complex process that involves various molecular mechanisms, including epigenetic regulation. DNA methylation has been shown to play central roles in regulating gene expression and modulating cell response during infection. However, the nature and extent to which DNA methylation is involved in the host immune response in human malaria remains largely unknown. Here, we present a longitudinal study investigating the temporal dynamics of genome-wide in vivo DNA methylation profiles using 189 MethylationEPIC 850 K profiles from 66 children in Burkina Faso, West Africa, sampled three times: before infection, during symptomatic parasitemia, and after malaria treatment. The results revealed major changes in the DNA methylation profiles of children in response to both Plasmodium falciparum infection and malaria treatment, with widespread hypomethylation of CpGs upon infection (82% of 6.8 K differentially methylated regions). We document a remarkable reversal of CpG methylation profiles upon treatment to pre-infection states. These changes implicate divergence in core immune processes, including the regulation of lymphocyte, neutrophil, and myeloid leukocyte function. Integrative DNA methylation-mRNA analysis of a top differentially methylated region overlapping the pro-inflammatory gene TNF implicates DNA methylation of TNF cis regulatory elements in the molecular mechanisms of TNF regulation in human malaria. Our results highlight a central role of epigenetic regulation in mounting the host immune response to P. falciparum infection and in response to malaria treatment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Almojil, Diawara, Soulama, Dieng, Manikandan, Sermé, Sombié, Diarra, Barry, Coulibaly, Sirima and Idaghdour.) |
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فهرسة مساهمة: | Keywords: DNA methyaltion; Plasmodium falciparum; TNF; host parasite interactions; malaria; methylome |
تواريخ الأحداث: | Date Created: 20230720 Latest Revision: 20230721 |
رمز التحديث: | 20230721 |
مُعرف محوري في PubMed: | PMC10352500 |
DOI: | 10.3389/fgene.2023.1197933 |
PMID: | 37470040 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-8021 |
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DOI: | 10.3389/fgene.2023.1197933 |