دورية أكاديمية
أعرض في EDS

Cardiometabolic Effects of DOCA-Salt in Mice Depend on Ambient Temperature.

التفاصيل البيبلوغرافية
العنوان: Cardiometabolic Effects of DOCA-Salt in Mice Depend on Ambient Temperature.
المؤلفون: Grobe CC; Department of Pediatrics (C.C.G., J.L.S.), Medical College of Wisconsin, Milwaukee., Reho JJ; Department of Physiology (J.J.R., D.B.-W., A.A.Z., N.M.M., S.B.R.L., E.M.F., D.T.B., K.K.W., P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee.; Comprehensive Rodent Metabolic Phenotyping Core (J.J.R., K.K.W., J.L.G.), Medical College of Wisconsin, Milwaukee., Brown-Williams D; Department of Physiology (J.J.R., D.B.-W., A.A.Z., N.M.M., S.B.R.L., E.M.F., D.T.B., K.K.W., P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee., Ziegler AA; Department of Physiology (J.J.R., D.B.-W., A.A.Z., N.M.M., S.B.R.L., E.M.F., D.T.B., K.K.W., P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee., Mathieu NM; Department of Physiology (J.J.R., D.B.-W., A.A.Z., N.M.M., S.B.R.L., E.M.F., D.T.B., K.K.W., P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee., Lawton SBR; Department of Physiology (J.J.R., D.B.-W., A.A.Z., N.M.M., S.B.R.L., E.M.F., D.T.B., K.K.W., P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee., Fekete EM; Department of Physiology (J.J.R., D.B.-W., A.A.Z., N.M.M., S.B.R.L., E.M.F., D.T.B., K.K.W., P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee., Brozoski DT; Department of Physiology (J.J.R., D.B.-W., A.A.Z., N.M.M., S.B.R.L., E.M.F., D.T.B., K.K.W., P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee., Wackman KK; Department of Physiology (J.J.R., D.B.-W., A.A.Z., N.M.M., S.B.R.L., E.M.F., D.T.B., K.K.W., P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee.; Comprehensive Rodent Metabolic Phenotyping Core (J.J.R., K.K.W., J.L.G.), Medical College of Wisconsin, Milwaukee., Burnett CML; Department of Medicine, Division of Cardiovascular Medicine (C.M.L.B.), Medical College of Wisconsin, Milwaukee., Nakagawa P; Department of Physiology (J.J.R., D.B.-W., A.A.Z., N.M.M., S.B.R.L., E.M.F., D.T.B., K.K.W., P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee.; Cardiovascular Center (P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee., Sigmund CD; Department of Physiology (J.J.R., D.B.-W., A.A.Z., N.M.M., S.B.R.L., E.M.F., D.T.B., K.K.W., P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee.; Cardiovascular Center (P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee.; Neuroscience Research Center (C.D.S., J.L.G.), Medical College of Wisconsin, Milwaukee., Segar JL; Department of Pediatrics (C.C.G., J.L.S.), Medical College of Wisconsin, Milwaukee.; Department of Physiology (J.J.R., D.B.-W., A.A.Z., N.M.M., S.B.R.L., E.M.F., D.T.B., K.K.W., P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee.; Cardiovascular Center (P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee., Grobe JL; Department of Physiology (J.J.R., D.B.-W., A.A.Z., N.M.M., S.B.R.L., E.M.F., D.T.B., K.K.W., P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee.; Comprehensive Rodent Metabolic Phenotyping Core (J.J.R., K.K.W., J.L.G.), Medical College of Wisconsin, Milwaukee.; Cardiovascular Center (P.N., C.D.S., J.L.S., J.L.G.), Medical College of Wisconsin, Milwaukee.; Neuroscience Research Center (C.D.S., J.L.G.), Medical College of Wisconsin, Milwaukee.; Department of Biomedical Engineering (J.L.G.), Medical College of Wisconsin, Milwaukee.
المصدر: Hypertension (Dallas, Tex. : 1979) [Hypertension] 2023 Sep; Vol. 80 (9), pp. 1871-1880. Date of Electronic Publication: 2023 Jul 20.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Lippincott, Williams & Wilkins Country of Publication: United States NLM ID: 7906255 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4563 (Electronic) Linking ISSN: 0194911X NLM ISO Abbreviation: Hypertension Subsets: MEDLINE
أسماء مطبوعة: Publication: : Hagerstown, MD : Lippincott, Williams & Wilkins
Original Publication: [Dallas, Tex.] : [American Heart Association], [©1979]-
مواضيع طبية MeSH: Desoxycorticosterone Acetate*/pharmacology , Hypertension*/chemically induced, Humans ; Mice ; Animals ; Temperature ; Mice, Inbred C57BL ; Blood Pressure/physiology ; Desoxycorticosterone/pharmacology
مستخلص: Background: Mice prefer warmer environments than humans. For this reason, behavioral and physiological thermoregulatory responses are engaged by mice in response to a standard room temperature of 22 to 24 °C. Autonomic mechanisms mediating thermoregulatory responses overlap with mechanisms activated in hypertension, and, therefore, we hypothesized that housing at thermoneutral temperatures (TNs; 30 °C) would modify the cardiometabolic effects of deoxycorticosterone acetate (DOCA)-salt in mice.
Methods: The effects of DOCA-salt treatment upon ingestive behaviors, energy expenditure, blood pressure, heart rate (HR), and core temperature were assessed in C57BL/6J mice housed at room temperature or TN.
Results: Housing at TN reduced food intake, energy expenditure, blood pressure, and HR and attenuated HR responses to acute autonomic blockade by chlorisondamine. At room temperature, DOCA-salt caused expected increases in fluid intake, sodium retention in osmotically inactive pools, blood pressure, core temperature, and also caused expected decreases in fat-free mass, total body water, and HR. At TN, the effects of DOCA-salt upon fluid intake, fat gains, hydration, and core temperature were exaggerated, but effects on energy expenditure and HR were blunted. Effects of DOCA-salt upon blood pressure were similar for 3 weeks and exaggerated by TN housing in the fourth week.
Conclusions: Ambient temperature robustly influences behavioral and physiological functions in mice, including metabolic and cardiovascular phenotype development in response to DOCA-salt treatment. Studying cardiometabolic responses of mice at optimal ambient temperatures promises to improve the translational relevance of rodent models.
Competing Interests: Disclosures None.
References: J Korean Med Sci. 2001 Oct;16(5):553-7. (PMID: 11641522)
Physiol Rep. 2015 Dec;3(12):. (PMID: 26702076)
Am J Physiol Regul Integr Comp Physiol. 2022 Oct 1;323(4):R410-R421. (PMID: 35816717)
Circulation. 2020 Mar 3;141(9):e120-e138. (PMID: 31992057)
Cell Metab. 2010 Nov 3;12(5):431-42. (PMID: 21035755)
Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H203-8. (PMID: 14975935)
Circulation. 1971 Dec;44(6):971-4. (PMID: 5127839)
Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1581-8. (PMID: 18245567)
J Pharmacol Toxicol Methods. 1992 May;27(3):161-70. (PMID: 1498343)
Hypertension. 2011 Mar;57(3):600-7. (PMID: 21263123)
Nat Rev Neurosci. 2022 Jan;23(1):35-52. (PMID: 34728833)
Am J Physiol Renal Physiol. 2005 Oct;289(4):F793-802. (PMID: 15914779)
Physiology (Bethesda). 2014 Nov;29(6):413-20. (PMID: 25362635)
Hypertens Res. 2000 Mar;23(2):109-18. (PMID: 10770257)
J Clin Invest. 2017 Apr 3;127(4):1414-1424. (PMID: 28263184)
Pharmacology. 1993 Apr;46(4):198-205. (PMID: 8483966)
Physiol Behav. 2017 Oct 1;179:55-66. (PMID: 28533176)
J Am Assoc Lab Anim Sci. 2022 Mar 1;61(2):132-139. (PMID: 34996529)
Auton Neurosci. 2022 Jan;237:102918. (PMID: 34823147)
Am J Physiol Renal Physiol. 2003 Dec;285(6):F1108-17. (PMID: 12888617)
Hypertension. 2020 Jun;75(6):1615-1623. (PMID: 32336228)
Hypertension. 2010 Jan;55(1):172-9. (PMID: 19901158)
Alcohol Alcohol. 2004 Sep-Oct;39(5):410-7. (PMID: 15289207)
Am J Physiol Regul Integr Comp Physiol. 2022 Jun 1;322(6):R467-R485. (PMID: 35348007)
Cell Rep. 2020 Apr 14;31(2):107501. (PMID: 32294435)
Mol Metab. 2015 Mar 10;4(6):461-70. (PMID: 26042200)
Front Physiol. 2022 Feb 25;13:855054. (PMID: 35283781)
Exp Physiol. 2010 Jan;95(1):51-5. (PMID: 19700514)
Am J Physiol Heart Circ Physiol. 2022 Feb 1;322(2):H234-H245. (PMID: 34919456)
Hypertens Res. 2023 Jan;46(1):231-235. (PMID: 36224284)
Mol Metab. 2012 Nov 08;2(1):5-9. (PMID: 24024125)
Am J Physiol. 1986 Aug;251(2 Pt 2):H261-8. (PMID: 3526927)
Am J Physiol Regul Integr Comp Physiol. 2021 Jan 1;320(1):R44-R54. (PMID: 33085913)
Can Med Assoc J. 1943 Aug;49(2):88-92. (PMID: 20322846)
Am J Physiol Regul Integr Comp Physiol. 2004 Aug;287(2):R391-6. (PMID: 15087284)
Hypertension. 2013 Mar;61(3):716-22. (PMID: 23266541)
Hypertension. 2018 Oct;72(4):854-861. (PMID: 30354719)
معلومات مُعتمدة: T32 HL007852 United States HL NHLBI NIH HHS; R01 HL134850 United States HL NHLBI NIH HHS; P01 HL084207 United States HL NHLBI NIH HHS; UL1 TR001436 United States TR NCATS NIH HHS; R01 DK133121 United States DK NIDDK NIH HHS; P01 HL014388 United States HL NHLBI NIH HHS; R35 HL144807 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: animals; body water; electrolytes; metabolism
المشرفين على المادة: 6E0A168OB8 (Desoxycorticosterone Acetate)
40GP35YQ49 (Desoxycorticosterone)
تواريخ الأحداث: Date Created: 20230720 Date Completed: 20230818 Latest Revision: 20231003
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC10528934
DOI: 10.1161/HYPERTENSIONAHA.122.20415
PMID: 37470185
قاعدة البيانات: MEDLINE
الوصف
تدمد:1524-4563
DOI:10.1161/HYPERTENSIONAHA.122.20415