دورية أكاديمية
أعرض في EDS

Genomic and phenotypic evolution of nematode-infecting microsporidia.

التفاصيل البيبلوغرافية
العنوان: Genomic and phenotypic evolution of nematode-infecting microsporidia.
المؤلفون: Wadi L; Department of Molecular Genetics, University of Toronto, Toronto, Canada., El Jarkass HT; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Tran TD; Department of Biology, San Diego State University, San Diego, California, United States of America., Islah N; Department of Molecular Genetics, University of Toronto, Toronto, Canada., Luallen RJ; Department of Biology, San Diego State University, San Diego, California, United States of America., Reinke AW; Department of Molecular Genetics, University of Toronto, Toronto, Canada.
المصدر: PLoS pathogens [PLoS Pathog] 2023 Jul 20; Vol. 19 (7), pp. e1011510. Date of Electronic Publication: 2023 Jul 20 (Print Publication: 2023).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science, c2005-
مواضيع طبية MeSH: Microsporidia*/genetics , Nematoda*/genetics, Animals ; Phylogeny ; Caenorhabditis elegans/genetics ; Genomics
مستخلص: Microsporidia are a large phylum of intracellular parasites that can infect most types of animals. Species in the Nematocida genus can infect nematodes including Caenorhabditis elegans, which has become an important model to study mechanisms of microsporidia infection. To understand the genomic properties and evolution of nematode-infecting microsporidia, we sequenced the genomes of nine species of microsporidia, including two genera, Enteropsectra and Pancytospora, without any previously sequenced genomes. Core cellular processes, including metabolic pathways, are mostly conserved across genera of nematode-infecting microsporidia. Each species encodes unique proteins belonging to large gene families that are likely used to interact with host cells. Most strikingly, we observed one such family, NemLGF1, is present in both Nematocida and Pancytospora species, but not any other microsporidia. To understand how Nematocida phenotypic traits evolved, we measured the host range, tissue specificity, spore size, and polar tube length of several species in the genus. Our phylogenetic analysis shows that Nematocida is composed of two groups of species with distinct traits and that species with longer polar tubes infect multiple tissues. Together, our work details both genomic and trait evolution between related microsporidia species and provides a useful resource for further understanding microsporidia evolution and infection mechanisms.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Wadi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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معلومات مُعتمدة: P40 OD010440 United States OD NIH HHS
تواريخ الأحداث: Date Created: 20230720 Date Completed: 20230802 Latest Revision: 20230804
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10393165
DOI: 10.1371/journal.ppat.1011510
PMID: 37471459
قاعدة البيانات: MEDLINE
الوصف
تدمد:1553-7374
DOI:10.1371/journal.ppat.1011510