دورية أكاديمية
أعرض في EDS

Disability and persistent motor deficits are linked to structural crossed cerebellar diaschisis in chronic stroke.

التفاصيل البيبلوغرافية
العنوان: Disability and persistent motor deficits are linked to structural crossed cerebellar diaschisis in chronic stroke.
المؤلفون: Guder S; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sadeghi F; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Zittel S; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Quandt F; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Choe CU; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Bönstrup M; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.; Department of Neurology, University Medical Center Leipzig, Leipzig, Germany., Cheng B; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Thomalla G; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Gerloff C; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Schulz R; Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
المصدر: Human brain mapping [Hum Brain Mapp] 2023 Nov; Vol. 44 (16), pp. 5336-5345. Date of Electronic Publication: 2023 Jul 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 9419065 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0193 (Electronic) Linking ISSN: 10659471 NLM ISO Abbreviation: Hum Brain Mapp Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Wiley
Original Publication: New York : Wiley-Liss, c1993-
مواضيع طبية MeSH: Diaschisis* , Stroke*/complications , Stroke*/diagnostic imaging , Stroke*/pathology, Humans ; Cross-Sectional Studies ; Cerebellum/diagnostic imaging ; Cerebellum/pathology ; Magnetic Resonance Imaging/methods ; Brain Damage, Chronic/pathology ; Cerebrovascular Circulation
مستخلص: Brain imaging has significantly contributed to our understanding of the cerebellum being involved in recovery after non-cerebellar stroke. Due to its connections with supratentorial brain networks, acute stroke can alter the function and structure of the contralesional cerebellum, known as crossed cerebellar diaschisis (CCD). Data on the spatially precise distribution of structural CCD and their implications for persistent deficits after stroke are notably limited. In this cross-sectional study, structural MRI and clinical data were analyzed from 32 chronic stroke patients, at least 6 months after the event. We quantified lobule-specific contralesional atrophy, as a surrogate of structural CCD, in patients and healthy controls. Volumetric data were integrated with clinical scores of disability and motor deficits. Diaschisis-outcome models were adjusted for the covariables age, lesion volume, and damage to the corticospinal tract. We found that structural CCD was evident for the whole cerebellum, and particularly for lobules V and VI. Lobule VI diaschisis was significantly correlated with clinical scores, that is, volume reductions in contralesional lobule VI were associated with higher levels of disability and motor deficits. Lobule V and the whole cerebellum did not show similar diaschisis-outcome relationships across the spectrum of the clinical scores. These results provide novel insights into stroke-related cerebellar plasticity and might thereby promote lobule VI as a key area prone to structural CCD and potentially involved in recovery and residual motor functioning.
(© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)
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فهرسة مساهمة: Keywords: CCD; atrophy; motor; recovery; stroke
تواريخ الأحداث: Date Created: 20230720 Date Completed: 20231003 Latest Revision: 20231004
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC10543354
DOI: 10.1002/hbm.26434
PMID: 37471691
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-0193
DOI:10.1002/hbm.26434