دورية أكاديمية
Exercise does not influence development of phenotype in PLN p.(Arg14del) cardiomyopathy.
| العنوان: | Exercise does not influence development of phenotype in PLN p.(Arg14del) cardiomyopathy. |
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| المؤلفون: | van Lint FHM; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.; Department of Human Genetics, Amsterdam University Medical Centres, location Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Hassanzada F; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands., Verstraelen TE; Heart Centre, Department of Cardiology, Amsterdam University Medical Centre, location Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, Amsterdam, The Netherlands., Wang W; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Bosman LP; Netherlands Heart Institute, Utrecht, The Netherlands.; Department of Cardiology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands., van der Zwaag PA; University Medical Centre Groningen, Department of Genetics, University of Groningen, Groningen, The Netherlands., Oomen T; Department of Cardiology, St. Antonius Hospital, Sneek, The Netherlands., Calkins H; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Murray B; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Tichnell C; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Beuren TMA; Department of Human Genetics, Amsterdam University Medical Centres, location Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Asselbergs FW; Department of Cardiology, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands., Houweling A; Department of Human Genetics, Amsterdam University Medical Centres, location Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands., van den Berg MP; Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands., Wilde AAM; Heart Centre, Department of Cardiology, Amsterdam University Medical Centre, location Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.; Amsterdam Cardiovascular Sciences, Heart Failure and Arrhythmias, Amsterdam, The Netherlands., James CA; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., van Tintelen JP; Department of Genetics, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands. j.p.vantintelen-3@umcutrecht.nl.; Department of Human Genetics, Amsterdam University Medical Centres, location Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. j.p.vantintelen-3@umcutrecht.nl.; Netherlands Heart Institute, Utrecht, The Netherlands. j.p.vantintelen-3@umcutrecht.nl. |
| المصدر: | Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation [Neth Heart J] 2023 Aug; Vol. 31 (7-8), pp. 291-299. Date of Electronic Publication: 2023 Jul 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bohn Stafleu van Loghum Country of Publication: Netherlands NLM ID: 101095458 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1568-5888 (Print) Linking ISSN: 15685888 NLM ISO Abbreviation: Neth Heart J Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: Houten : Bohn Stafleu van Loghum Original Publication: Leusden, The Netherlands : Mediselect bv, c2001- |
| مستخلص: | Background: Endurance and frequent exercise are associated with earlier onset of arrhythmogenic right ventricular cardiomyopathy (ARVC) and ventricular arrhythmias (VA) in desmosomal gene variant carriers. Individuals with the pathogenic c.40_42del; p.(Arg14del) variant in the PLN gene are frequently diagnosed with ARVC or dilated cardiomyopathy (DCM). The aim of this study was to evaluate the effect of exercise in PLN p.(Arg14del) carriers. Methods: In total, 207 adult PLN p.(Arg14del) carriers (39.1% male; mean age 53 ± 15 years) were interviewed on their regular physical activity since the age of 10 years. The association of exercise with diagnosis of ARVC, DCM, sustained VA and hospitalisation for heart failure (HF) was studied. Results: Individuals participated in regular physical activities with a median of 1661 metabolic equivalent of task (MET) hours per year (31.9 MET-hours per week) until clinical presentation. The 50% most and least active individuals had a similar frequency of sustained VA (18.3% vs 18.4%; p = 0.974) and hospitalisation for HF (9.6% vs 8.7%; p = 0.827). There was no relationship between exercise and survival free from (incident) sustained VA (p = 0.65), hospitalisation for HF (p = 0.81), diagnosis of ARVC (p = 0.67) or DCM (p = 0.39) during follow-up. In multivariate analyses, exercise was not associated with sustained VA or HF hospitalisation during follow-up in this relatively not-active cohort. Conclusion: There was no association between the amount of exercise and the susceptibility to develop ARVC, DCM, VA or HF in PLN p.(Arg14del) carriers. This suggested unaffected PLN p.(Arg14del) carriers can safely perform mild-moderate exercise, in contrast to desmosomal variant carriers and ARVC patients. (© 2023. The Author(s).) |
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| معلومات مُعتمدة: | CUREPLaN Fondation Leducq; several: see text articla Hartstichting; several: see text article Hartstichting |
| فهرسة مساهمة: | Keywords: Arrhythmogenic right ventricular cardiomyopathy; Dilated cardiomyopathy; Exercise; Genetics; Penetrance |
| تواريخ الأحداث: | Date Created: 20230720 Latest Revision: 20230807 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC10400740 |
| DOI: | 10.1007/s12471-023-01800-4 |
| PMID: | 37474840 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1568-5888 |
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| DOI: | 10.1007/s12471-023-01800-4 |