دورية أكاديمية
Health-related quality of life analyses in nonfunctioning pituitary macroadenoma patients identifies at-risk populations.
| العنوان: | Health-related quality of life analyses in nonfunctioning pituitary macroadenoma patients identifies at-risk populations. |
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| المؤلفون: | Wisdom AJ; Harvard Radiation Oncology Program, Boston, MA, USA., Dyer MA; Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Horick NK; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Yeap BY; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Miller KK; Harvard Medical School, Boston, MA, USA.; Division of Endocrinology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA., Swearingen B; Harvard Medical School, Boston, MA, USA.; Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, USA., Loeffler JS; Harvard Medical School, Boston, MA, USA.; Department of Radiation Oncology, Massachusetts General Hospital, 30 Fruit Street, 02114, Boston, MA, USA., Shih HA; Harvard Medical School, Boston, MA, USA. hshih@mgh.harvard.edu.; Department of Radiation Oncology, Massachusetts General Hospital, 30 Fruit Street, 02114, Boston, MA, USA. hshih@mgh.harvard.edu. |
| المصدر: | Pituitary [Pituitary] 2023 Aug; Vol. 26 (4), pp. 510-520. Date of Electronic Publication: 2023 Jul 21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Kluwer Academic Publishers Country of Publication: United States NLM ID: 9814578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7403 (Electronic) Linking ISSN: 1386341X NLM ISO Abbreviation: Pituitary Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Norwell, MA : Kluwer Academic Publishers, 1998- |
| مواضيع طبية MeSH: | Pituitary Neoplasms*/radiotherapy , Pituitary Neoplasms*/surgery , Hypopituitarism*/diagnosis, Humans ; Middle Aged ; Quality of Life ; Surveys and Questionnaires ; Fatigue ; Treatment Outcome |
| مستخلص: | Purpose: The quality of life (QoL) impact of multidisciplinary treatment for patients with nonfunctioning pituitary macroadenomas (NFPMA) is unclear. We sought to investigate associations between patient factors, clinical data, and patient-reported QoL in patients with NFPMA. Methods: Patients with treated NFPMA and > 1 year of follow up after transsphenoidal surgery (TSS) and with no evidence of progressive disease were evaluated utilizing the following patient-reported outcome measures: RAND-36-Item Health Survey, Multidimensional Fatigue Inventory, Cognitive Failures Questionnaire. Results: 229 eligible patients completed QoL questionnaires a median of 7.7 years after initial transsphenoidal surgery (TSS). 25% of participants received radiation therapy (RT) a median of 2.0 years (0.1-22.5) after initial TSS. Patients who received RT were younger (median age 46 v 58, p < 0.0001), had larger tumors (28 mm v 22 mm, p < 0.0001), were more likely to have visual symptoms (65% v 34%, p = 0.0002), and were more likely to have hypopituitarism (93% v 62%, p < 0.0001). Patients with hypopituitarism reported worse energy and fatigue and cognitive function (p < 0.03). Patients who received RT reported significantly worse general health, physical health, physical fatigue and cognitive functioning (p < 0.05). The largest QoL differences were in patients who experienced a financial stressor, independent of treatment type. Conclusion: Hypopituitarism, radiation therapy after TSS, and financial stressors are associated with more impaired QoL in patients with NFPMA. Awareness of these factors can better guide use and timing of radiation therapy in addition to identifying patients who can benefit from multidisciplinary surveillance. (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Hypopituitarism; Nonfunctioning macroadenoma; Pituitary adenoma; Quality of life; Radiation therapy; Transsphenoidal surgery |
| تواريخ الأحداث: | Date Created: 20230721 Date Completed: 20230803 Latest Revision: 20230803 |
| رمز التحديث: | 20230803 |
| DOI: | 10.1007/s11102-023-01334-3 |
| PMID: | 37477853 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-7403 |
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| DOI: | 10.1007/s11102-023-01334-3 |