Clonal relationship, virulence genes, and antimicrobial resistance of Morganella morganii isolated from community-acquired infections and hospitalized patients: a neglected opportunistic pathogen.

التفاصيل البيبلوغرافية
العنوان:	Clonal relationship, virulence genes, and antimicrobial resistance of Morganella morganii isolated from community-acquired infections and hospitalized patients: a neglected opportunistic pathogen.
المؤلفون:	Silva LC; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid PO-BOX 6001, 86051-980, Londrina, Paraná, Brazil., Sanches MS; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid PO-BOX 6001, 86051-980, Londrina, Paraná, Brazil., Guidone GHM; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid PO-BOX 6001, 86051-980, Londrina, Paraná, Brazil., Montini VH; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid PO-BOX 6001, 86051-980, Londrina, Paraná, Brazil., de Oliva BHD; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid PO-BOX 6001, 86051-980, Londrina, Paraná, Brazil., do Nascimento AB; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid PO-BOX 6001, 86051-980, Londrina, Paraná, Brazil., Galhardi LCF; Laboratory of Virology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Londrina, Brazil., Kobayashi RKT; Laboratory of Basic and Applied Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Londrina, Brazil., Vespero EC; Department of Pathology, Clinical and Toxicological Analysis, Health Sciences Center, University Hospital of Londrina, State University of Londrina, Paraná, Brazil., Rocha SPD; Laboratory of Bacteriology, Department of Microbiology, Center of Biological Sciences, State University of Londrina, Rodovia Celso Garcia Cid PO-BOX 6001, 86051-980, Londrina, Paraná, Brazil. rochaspd@uel.br.
المصدر:	International microbiology : the official journal of the Spanish Society for Microbiology [Int Microbiol] 2024 Apr; Vol. 27 (2), pp. 411-422. Date of Electronic Publication: 2023 Jul 21.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Springer Nature Country of Publication: Switzerland NLM ID: 9816585 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-1905 (Electronic) Linking ISSN: 11396709 NLM ISO Abbreviation: Int Microbiol Subsets: MEDLINE
أسماء مطبوعة:	Publication: 2018- : Switzerland AG : Springer Nature Original Publication: Barcelona, Spain : Springer, c1998-
مواضيع طبية MeSH:	Morganella morganii/genetics , Community-Acquired Infections/drug therapy , Urinary Tract Infections*/microbiology, Humans ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Virulence/genetics ; Drug Resistance, Bacterial/genetics ; Virulence Factors/genetics ; beta-Lactamases/genetics ; Microbial Sensitivity Tests
مستخلص:	Morganella morganii is a bacterium belonging to the normal intestinal microbiota and the environment; however, in immunocompromised individuals, this bacterium can become an opportunistic pathogen, causing a series of diseases, both in hospitals and in the community, being urinary tract infections more prevalent. Therefore, the objective of this study was to evaluate the prevalence, virulence profile, and resistance to antimicrobials and the clonal relationship of isolates of urinary tract infections (UTI) caused by M. morganii, both in the hospital environment and in the community of the municipality of Londrina-PR, in southern Brazil, in order to better understand the mechanisms for the establishment of the disease caused by this bacterium. Our study showed that M. morganii presents a variety of virulence factors in the studied isolates. Hospital strains showed a higher prevalence for the virulence genes zapA, iutA, and fimH, while community strains showed a higher prevalence for the ireA and iutA genes. Hospital isolates showed greater resistance compared to community isolates, as well as a higher prevalence of multidrug-resistant (MDR) and extended-spectrum beta lactamase (ESBL)-producing isolates. Several M. morganii isolates from both sources showed high genetic similarity. The most prevalent plasmid incompatibility groups detected were FIB and I1, regardless of the isolation source. Thus, M. morganii isolates can accumulate virulence factors and antimicrobial resistance, making them a neglected opportunistic pathogen. (© 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
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فهرسة مساهمة:	Keywords: Morganella morganii; Antimicrobial resistance; Epidemiology; Opportunistic pathogen; UTI
المشرفين على المادة:	0 (Anti-Bacterial Agents) 0 (Virulence Factors) EC 3.5.2.6 (beta-Lactamases)
تواريخ الأحداث:	Date Created: 20230721 Date Completed: 20240405 Latest Revision: 20240405
رمز التحديث:	20240405
DOI:	10.1007/s10123-023-00400-x
PMID:	37479959
قاعدة البيانات:	MEDLINE

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تدمد:	1618-1905
DOI:	10.1007/s10123-023-00400-x