دورية أكاديمية
Histone H4K16ac Binding Function of the Triple PHD Finger Cassette of MLL4.
العنوان: | Histone H4K16ac Binding Function of the Triple PHD Finger Cassette of MLL4. |
---|---|
المؤلفون: | Kumar Sinha V; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Zhang Y; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Xu L; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Chen YW; Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan., Picaud S; Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, UK., Zandian M; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Biswas S; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA., Filippakopoulos P; Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7DQ, UK., Wang SP; Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan., Shi X; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI 49503, USA., Kutateladze TG; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO 80045, USA. Electronic address: tatiana.kutateladze@cuanschutz.edu. |
المصدر: | Journal of molecular biology [J Mol Biol] 2024 Apr 01; Vol. 436 (7), pp. 168212. Date of Electronic Publication: 2023 Jul 20. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: 1959- : London : Academic Press |
مواضيع طبية MeSH: | Histone-Lysine N-Methyltransferase*/chemistry , Histone-Lysine N-Methyltransferase*/metabolism , Histones*/metabolism , PHD Zinc Fingers*, Humans ; Lysine/metabolism ; Protein Binding |
مستخلص: | The human methyltransferase MLL4 plays a critical role in embryogenesis and development, and aberrant activity of MLL4 is linked to neurodegenerative and developmental disorders and cancer. MLL4 contains the catalytic SET domain that catalyzes mono methylation of lysine 4 of histone H3 (H3K4me1) and seven plant homeodomain (PHD) fingers, six of which have not been structurally and functionally characterized. Here, we demonstrate that the triple PHD finger cassette of MLL4, harboring its fourth, fifth and sixth PHD fingers (MLL4 Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2023 Elsevier Ltd. All rights reserved.) |
References: | J Biol Chem. 2023 Apr;299(4):104601. (PMID: 36907441) Nat Chem Biol. 2016 Aug 18;12(9):662-8. (PMID: 27538025) Chem Rev. 2015 Mar 25;115(6):2376-418. (PMID: 25688442) Trends Neurosci. 2018 Sep;41(9):587-598. (PMID: 29885742) Genes Dev. 2012 Dec 15;26(24):2749-62. (PMID: 23249737) Biochim Biophys Acta. 2014 Feb;1843(2):366-71. (PMID: 24291127) Nat Commun. 2020 Oct 29;11(1):5466. (PMID: 33122719) Nat Commun. 2013;4:2969. (PMID: 24352064) Nucleic Acids Res. 2011 Nov;39(21):9061-71. (PMID: 21813457) Science. 2006 Feb 10;311(5762):844-7. (PMID: 16469925) Structure. 2020 Jan 7;28(1):105-110.e3. (PMID: 31711755) Curr Opin Struct Biol. 2021 Dec;71:1-6. (PMID: 33993059) Cell. 2012 Jul 6;150(1):12-27. (PMID: 22770212) Nat Commun. 2019 Jan 3;10(1):36. (PMID: 30604749) Nucleic Acids Res. 2016 Jan 8;44(1):472-84. (PMID: 26626149) Nat Commun. 2019 May 24;10(1):2314. (PMID: 31127101) Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11871-11876. (PMID: 27698142) Cell Rep. 2017 Oct 10;21(2):455-466. (PMID: 29020631) Nat Commun. 2019 Oct 17;10(1):4724. (PMID: 31624313) Nat Commun. 2021 Jul 5;12(1):4130. (PMID: 34226546) Gene. 2017 Sep 5;627:337-342. (PMID: 28669924) Genes Dev. 2006 May 15;20(10):1256-61. (PMID: 16648462) Dev Cell. 2013 Apr 15;25(1):55-68. (PMID: 23523075) Mol Interv. 2009 Dec;9(6):314-23. (PMID: 20048137) Mol Cell. 2000 Feb;5(2):367-75. (PMID: 10882077) Nature. 2009 Jun 11;459(7248):802-7. (PMID: 19516333) Mol Cell Biol. 2010 Nov;30(22):5335-47. (PMID: 20837706) Mol Cell. 2017 Jul 20;67(2):308-321.e6. (PMID: 28732206) Nat Struct Mol Biol. 2007 Nov;14(11):1025-1040. (PMID: 17984965) Nat Struct Mol Biol. 2012 Dec;19(12):1218-27. (PMID: 23211769) Elife. 2013 Dec 24;2:e01503. (PMID: 24368734) Cell. 2016 Aug 11;166(4):822-839. (PMID: 27518561) Angew Chem Int Ed Engl. 2011 Oct 4;50(41):9611-4. (PMID: 21922615) |
معلومات مُعتمدة: | R01 GM125195 United States GM NIGMS NIH HHS; R01 CA252707 United States CA NCI NIH HHS; R01 GM135671 United States GM NIGMS NIH HHS; R01 CA268440 United States CA NCI NIH HHS; R01 HL151334 United States HL NHLBI NIH HHS; R01 AG067664 United States AG NIA NIH HHS; R56 AG067664 United States AG NIA NIH HHS |
فهرسة مساهمة: | Keywords: H4K16ac; MLL4; PHD finger; acetylation; histone |
المشرفين على المادة: | EC 2.1.1.43 (Histone-Lysine N-Methyltransferase) 0 (Histones) K3Z4F929H6 (Lysine) EC 2.1.1.43 (MLL4 protein, human) |
تواريخ الأحداث: | Date Created: 20230722 Date Completed: 20240325 Latest Revision: 20240714 |
رمز التحديث: | 20240714 |
مُعرف محوري في PubMed: | PMC10799173 |
DOI: | 10.1016/j.jmb.2023.168212 |
PMID: | 37481158 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1089-8638 |
---|---|
DOI: | 10.1016/j.jmb.2023.168212 |