Confirmed Synergy Between the ɛ4 Allele of Apolipoprotein E and the Variant K of Butyrylcholinesterase as a Risk Factor for Alzheimer's Disease: A Systematic Review and Meta-Analysis.
| العنوان: | Confirmed Synergy Between the ɛ4 Allele of Apolipoprotein E and the Variant K of Butyrylcholinesterase as a Risk Factor for Alzheimer's Disease: A Systematic Review and Meta-Analysis. |
|---|---|
| المؤلفون: | Ratis RC; Laboratory of Neurosciences and Behavior, Department of Pharmacy, State University of the Midwest, Paraná, Brazil., Dacoregio MI; Faculty of Medicine, State University of the Midwest, Paraná, Brazil., Simão-Silva DP; Post-Graduate Program in Intellectual Property and Technology Transfer for Innovation, State University of the Midwest, Paraná, Brazil., Mateus RP; Evolutionary Biology Laboratory, Department of Biology, State University of the Midwest, Paraná, Brazil., Machado LPB; Evolutionary Biology Laboratory, Department of Biology, State University of the Midwest, Paraná, Brazil., Bonini JS; Laboratory of Neurosciences and Behavior, Department of Pharmacy, State University of the Midwest, Paraná, Brazil., da Silva WCFN; Laboratory of Neuropsychopharmacology, Department of Pharmacy, State University of the Midwest, Paraná, Brazil. |
| المصدر: | Journal of Alzheimer's disease reports [J Alzheimers Dis Rep] 2023 Jun 19; Vol. 7 (1), pp. 613-625. Date of Electronic Publication: 2023 Jun 19 (Print Publication: 2023). |
| نوع المنشور: | Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOS Press Country of Publication: Netherlands NLM ID: 101705500 Publication Model: eCollection Cited Medium: Internet ISSN: 2542-4823 (Electronic) Linking ISSN: 25424823 NLM ISO Abbreviation: J Alzheimers Dis Rep Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : IOS Press, [2017]- |
| مستخلص: | Background: Alzheimer's disease (AD) has several risk factors. APOE4 is the main one, and it has been suggested that there may be a synergy between it and BCHE-K as a risk factor. Objective: To investigate the association between APOE4 and BCHE-K as a risk factor for AD. Methods: We searched PubMed, Web of Science, Embase, and Scopus on August 8, 2021 for studies that analyzed the association of APOE4 and BCHE-K with AD. The random effect model was performed in meta-analysis according to age group. A chi-square was performed with the meta-analysis data to verify if the effect found is not associated only with the E4 allele. Results: Twenty-one studies with 6,853 subjects (3,528 AD and 3,325 Controls) were included in the meta-analysis. The quality of the evidence is moderate. There is a positive E4-K association for subjects with AD as shown by the odds ratio of 3.43. The chi-square meta test, which measures the probability that the E4-K association is due to chance, has an odds ratio of 6.155, indicating that the E4-K association is not a random event. The odds ratio of an E4-K association in subjects with AD increases to OR 4.46 for the 65- to 75-year-old group and OR 4.15 for subjects older than 75 years. The probability that the E4-K association is due to chance is ruled out by chi-square meta test values of OR 8.638 and OR 9.558. Conclusion: The synergy between APOE4 and BCHE-K is a risk factor for late-onset AD. Competing Interests: The authors have no conflict of interest to report. (© 2023 – The authors. Published by IOS Press.) |
| References: | J Neurol. 1999 May;246(5):369-70. (PMID: 10399868) Chem Biol Interact. 2013 Mar 25;203(1):358-60. (PMID: 23022600) Eur J Med Chem. 2017 May 26;132:294-309. (PMID: 28371641) Neurosci Lett. 1999 Jul 9;269(2):115-9. (PMID: 10430518) Mol Neurobiol. 2019 Apr;56(4):2450-2465. (PMID: 30032423) Front Mol Neurosci. 2019 Jul 31;12:176. (PMID: 31417354) Lancet Neurol. 2021 Jan;20(1):68-80. (PMID: 33340485) Ann N Y Acad Sci. 2005 Dec;1057:260-78. (PMID: 16399900) Syst Rev. 2016 Dec 5;5(1):210. (PMID: 27919275) Syst Rev. 2019 Jun 26;8(1):151. (PMID: 31242929) Cell. 2017 Jan 26;168(3):427-441.e21. (PMID: 28111074) Neurosci Lett. 2004 Nov 23;371(2-3):142-6. (PMID: 15519745) Eur J Hum Genet. 1999 Sep;7(6):659-63. (PMID: 10482954) Stroke. 1998 Dec;29(12):2488-90. (PMID: 9836756) Annu Rev Pathol. 2022 Jan 24;17:73-99. (PMID: 34460318) J Alzheimers Dis. 2015;50(2):567-76. (PMID: 26757188) Front Immunol. 2017 Dec 07;8:1745. (PMID: 29270179) Neurobiol Aging. 2011 Dec;32(12):2320.e15-32. (PMID: 20538374) Am J Med Genet. 2000 Apr 3;96(2):167-9. (PMID: 10893490) J Alzheimers Dis. 2010;20 Suppl 2:S499-512. (PMID: 20413847) Pharmacol Ther. 2015 Apr;148:34-46. (PMID: 25448037) Neurosci Lett. 2017 Feb 22;641:101-106. (PMID: 28108398) Annu Rev Genomics Hum Genet. 2000;1:507-37. (PMID: 11701639) J Frailty Aging. 2014;3(2):97-103. (PMID: 27049901) Am J Med Genet B Neuropsychiatr Genet. 2007 Oct 5;144B(7):895-9. (PMID: 17503475) PLoS One. 2013 Nov 29;8(11):e81989. (PMID: 24312390) Ann Neurol. 1994 Nov;36(5):722-7. (PMID: 7979218) Nat Neurosci. 2003 Apr;6(4):345-51. (PMID: 12658281) Hum Mol Genet. 1997 Oct;6(11):1933-6. (PMID: 9302273) J Med Genet. 2000 Oct;37(10):766-70. (PMID: 11015454) J Neurol Neurosurg Psychiatry. 1999 Jul;67(1):94-6. (PMID: 10369830) Hum Mol Genet. 1998 May;7(5):937-9. (PMID: 9536100) BMJ. 2000 May 27;320(7247):1468. (PMID: 10827061) Neurosci Lett. 1998 Jun 19;249(2-3):115-8. (PMID: 9682830) J Neurol Neurosurg Psychiatry. 1999 Nov;67(5):693-4. (PMID: 10577037) Curr Alzheimer Res. 2016;13(10):1173-7. (PMID: 27040140) J Neural Transm (Vienna). 2010 Mar;117(3):377-83. (PMID: 20058037) BMJ. 2016 Oct 12;355:i4919. (PMID: 27733354) Molecules. 2020 Dec 08;25(24):. (PMID: 33302541) Clin Microbiol Infect. 2014 Feb;20(2):123-9. (PMID: 24320992) J Med Genet. 1998 Dec;35(12):1034-5. (PMID: 9863603) Dement Neurocogn Disord. 2018 Dec;17(4):131-136. (PMID: 30906402) Dement Geriatr Cogn Disord. 2011;31(1):20-30. (PMID: 21124030) Nat Med. 2020 Jun;26(6):952-963. (PMID: 32514169) J Med Genet. 2000 Mar;37(3):182-5. (PMID: 10699053) Am J Hum Genet. 1992 May;50(5):1086-103. (PMID: 1570838) Acta Neurol Scand. 2000 Dec;102(6):350-3. (PMID: 11125748) J Lipid Res. 2005 May;46(5):949-68. (PMID: 15716586) Hum Genet. 1999 Feb;104(2):158-63. (PMID: 10190327) Alzheimers Dement. 2018 Jul;14(7):869-879. (PMID: 29580670) Prog Neurobiol. 2021 Jul;202:102032. (PMID: 33716161) Endocrinology. 2004 Nov;145(11):4997-5005. (PMID: 15256494) Int J Surg. 2021 Apr;88:105906. (PMID: 33789826) Neurotoxicology. 2017 Jul;61:143-187. (PMID: 28363508) Neurosci Biobehav Rev. 2013 Dec;37(10 Pt 2):2878-86. (PMID: 24183852) Alzheimers Res Ther. 2020 Nov 4;12(1):141. (PMID: 33148345) Am J Med Genet. 1999 Apr 16;88(2):113-5. (PMID: 10206226) |
| فهرسة مساهمة: | Keywords: APOE; Alzheimer’s disease; BaβAC; cholinesterase; dementia; genetics; odds ratio |
| تواريخ الأحداث: | Date Created: 20230724 Latest Revision: 20230725 |
| رمز التحديث: | 20230725 |
| مُعرف محوري في PubMed: | PMC10357125 |
| DOI: | 10.3233/ADR-220084 |
| PMID: | 37483326 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2542-4823 |
|---|---|
| DOI: | 10.3233/ADR-220084 |